Results 261 to 270 of about 6,047,039 (310)
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Biological therapies in otology
HNO, 2017Hearing loss is present in millions of people worldwide. Current treatment for patients with severe to profound hearing loss consists of cochlear implantation. Providing the cochlear nerve is intact, patients generally benefit greatly from this intervention, frequently achieving significant improvements in speech comprehension. There are, however, some
A, Roemer +4 more
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Journal of Infusion Nursing, 2012
Biologic therapy includes a diverse group of drugs that act directly on the immune system. Sometimes referred to as "targeted therapy," the biologics include cytokines and monoclonal antibodies. These agents can be genetically engineered versions of naturally occurring substances, or novel compounds used for the treatment of cancer and for nononcology ...
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Biologic therapy includes a diverse group of drugs that act directly on the immune system. Sometimes referred to as "targeted therapy," the biologics include cytokines and monoclonal antibodies. These agents can be genetically engineered versions of naturally occurring substances, or novel compounds used for the treatment of cancer and for nononcology ...
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Biological Therapies in Osteoarthritis
Current Pharmaceutical Design, 2015Given the paucity of effective therapies and the increasing prevalence of osteoarthritis (OA) with ageing and overweight populations, new therapies for this painful, life-impairing condition are desperately needed, for both symptom relief and structural modification.
Claire Y J, Wenham +2 more
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Seminars in Respiratory and Critical Care Medicine, 2018
AbstractAlthough airway inflammation is an intrinsic and key feature of asthma, this response varies in its intensity and translation to clinical characteristics and responsiveness to treatment. The observations that clinical heterogeneity is an important aspect of asthma and a feature that likely dictates and determines responses to treatment in ...
Ravi K, Viswanathan, William W, Busse
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AbstractAlthough airway inflammation is an intrinsic and key feature of asthma, this response varies in its intensity and translation to clinical characteristics and responsiveness to treatment. The observations that clinical heterogeneity is an important aspect of asthma and a feature that likely dictates and determines responses to treatment in ...
Ravi K, Viswanathan, William W, Busse
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Pharmacoeconomics of Biologic Therapy
Immunology and Allergy Clinics of North America, 2017Novel biologic agents have allowed clinicians to achieve improved patient outcomes. Appropriate pharmacoceconomic analyses demand evaluation of all relevant costs, including the treatments, the disease and comorbidities, and costs of alternative treatments, including their short- and long-term side effects.
Don A, Bukstein, Allan T, Luskin
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Biological therapy for psoriasis
British Journal of Hospital Medicine, 2006Psoriasis is a common, chronic immune-mediated skin disorder. Recent advances in the understanding of the immunopathogenesis of psoriasis have led to the development of biological agents designed to target the molecular mechanisms of the condition. These provide new and effective treatments for patients with moderate to severe psoriasis.
Suzanne E, Clements +2 more
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Biologic therapies in dermatology
British Journal of Hospital Medicine, 2013Biologic therapies, the anti-cytokines in particular, have proved to be a significant addition to the dermatologist’s armamentarium for the management of severe skin disease. This article summarizes the mechanism of action, dosage, approved indications, off-label uses and the future of biologic therapies in dermatology.
Chularojanamontri, Leena +1 more
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The Immunogenicity of Biologic Therapies
2017Virtually all therapeutic proteins (biologics) elicit an immune response with the consequent production of anti-drug antibodies (ADA). The majority of ADA to therapeutic monoclonal antibodies (mAbs) are directed against the antigen-binding site of the therapeutic mAb, and hence are neutralizing.
Sandra, Garcês, Jocelyne, Demengeot
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Current Opinion in Oncology, 1999
Biologic approaches to lymphoma treatment are now a practical reality rather than a vaguely perceived hope for the future. Interferon alfa seems to have been established as a life-extending therapy for selected patients with follicular lymphoma. Humanized anti-CD20 monoclonal antibody (rituximab) has an authentic 50% response rate in patients with ...
M, Bendandi, D L, Longo
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Biologic approaches to lymphoma treatment are now a practical reality rather than a vaguely perceived hope for the future. Interferon alfa seems to have been established as a life-extending therapy for selected patients with follicular lymphoma. Humanized anti-CD20 monoclonal antibody (rituximab) has an authentic 50% response rate in patients with ...
M, Bendandi, D L, Longo
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The Future of Biological Therapies
Seminars in Cutaneous Medicine and Surgery, 2010The last decade has witnessed a significant advance in the management of refractory moderate-to-severe psoriasis. This advance is the introduction of biological therapies to clinical practice. Three classes of biological therapies have been used. Of the first 2 classes to be introduced, the T-cell inhibitors and tumor necrosis factor (TNF)-alpha ...
Warren, Richard B. +1 more
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