Results 111 to 120 of about 1,751,937 (284)

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Theory of Interface: Category Theory, Directed Networks and Evolution of Biological Networks [PDF]

, 2012
Biological networks have two modes. The first mode is static: a network is a passage on which something flows. The second mode is dynamic: a network is a pattern constructed by gluing functions of entities constituting the network.
Haruna, Taichi
core  

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Learning partial differential equations for biological transport models from noisy spatio-temporal data. [PDF]

Proc Math Phys Eng Sci, 2020
Lagergren JH, Nardini JT, Michael Lavigne G, Rutter EM, Flores KB.   +4 more
europepmc   +1 more source

Random walk with barriers: Diffusion restricted by permeable membranes

, 2010
Restrictions to molecular motion by barriers (membranes) are ubiquitous in biological tissues, porous media and composite materials. A major challenge is to characterize the microstructure of a material or an organism nondestructively using a bulk ...
A Aronovitz, A Kusumi, AL Sukstanskii, AN Norris, BL Altshuler, DA Yablonskiy, DG Cory, Dmitry S. Novikov, DS Fisher, DS Fisher, DS Novikov, E Abrahams, E Fieremans, E Marinari, E Sykova, E Warburg, Els Fieremans, F Crick, F Kohlrausch, H Scher, IV Lerner, J Machta, J-P Bouchaud, Jens H. Jensen, JG Powles, JM Kosterlitz, Joseph A. Helpern, JW Haus, KS Cole, KS Cole, L Wawrezinieck, LD Landau, LL Latour, M Avellaneda, M Wien, MH Ernst, MH Friedman, OK Dudko, PB Visscher, PJH Denteneer, PN Sen, PN Sen, PP Mitra, PT Callaghan, PT Callaghan, R Zwanzig, RM Cotts, RW Mair, T Fujiwara, VE Kravtsov, Y-Q Song, YG Sinai   +51 more
core   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Ions in motion: From biological channels to engineered transport systems

Giant
Natural membrane proteins are molecular machines evolved over billions of years, playing crucial roles in various physiological functions by precisely mediating transmembrane transport processes.
Bei Wu, Yifan Yan, Yuting Zhu, Changxing Ji, Yangyang Lin, Chao Lang   +5 more
doaj   +1 more source

Study on Photon Transport Problem Based on the Platform of Molecular Optical Simulation Environment

International Journal of Biomedical Imaging, 2010
As an important molecular imaging modality, optical imaging has attracted increasing attention in the recent years. Since the physical experiment is usually complicated and expensive, research methods based on simulation platforms have obtained extensive
Kuan Peng, Xinbo Gao, Jimin Liang, Xiaochao Qu, Nunu Ren, Xueli Chen, Bin Ma, Jie Tian   +7 more
doaj   +1 more source