A physical derivation of high-flux ion transport in biological channel via quantum ion coherence
Nature CommunicationsBiological ion channels usually conduct the high-flux transport of 107 ~ 108 ions·s− 1; however, the underlying mechanism is still lacking. Here, by applying the KcsA potassium channel as a typical example, and performing multitimescale molecular ...
Yue Wang +5 more
doaj +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Structure and transport properties of liquid clusters in a drying porous medium [PDF]
, 2003 The structure and transport properties of drying water clusters in porous media have been studied with a site-bond invasion percolation (IP) model.
Michels, MAJ Thijs +7 more
core +1 more source
Modelling the calendering process of lithium-ion battery electrodes using the Discrete Element Method (DEM) [PDF]
EPJ Web of ConferencesThe electrochemical performance of a lithium-ion battery is strongly influenced by the microstructure of its electrode. A dried electrode consists of the active material (AM) particles and carbon-binder domain (CBD) phase.
Tiwari Alok +4 more
doaj +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Biological Influences on Sediment Behavior and Transport
, 2011 The estuarine ecosystem is the integration of the physical system represented by sediment and hydrodynamics and the biological system represented by the flora and fauna living in the physical system and the ongoing biological processes.
M. Pejrup +3 more
core +1 more source
Intracellular Transport of Silver and Gold Nanoparticles and Biological Responses: An Update
International Journal of Molecular Sciences, 2018 Medicine, food, and cosmetics represent the new promising applications for silver (Ag) and gold (Au) nanoparticles (NPs). AgNPs are most commonly used in food and cosmetics; conversely, the main applications of gold NPs (AuNPs) are in the medical field ...
E. Panzarini +5 more
semanticscholar +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Transport phenomena in biological systems
, 2010 886 hlm. : ilus. ; tab.
TRUSKEY, GEORGE A +2 more
core