Results 81 to 90 of about 1,765,133 (301)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

A physical derivation of high-flux ion transport in biological channel via quantum ion coherence

open access: yesNature Communications
Biological ion channels usually conduct the high-flux transport of 107 ~ 108 ions·s− 1; however, the underlying mechanism is still lacking. Here, by applying the KcsA potassium channel as a typical example, and performing multitimescale molecular ...
Yue Wang   +5 more
doaj   +1 more source

Long-Lived Electronic Coherence in Dissipative Exciton-Dynamics of Light-Harvesting Complexes

open access: yes, 2012
The observed prevalence of oscillatory signals in the spectroscopy of biological light-harvesting complexes at ambient temperatures has led to a search for mechanisms supporting coherent transport through larger molecules in noisy environments.
Kramer, Tobias, Kreisbeck, Christoph
core   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

open access: yesFEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan   +5 more
wiley   +1 more source

Modelling the calendering process of lithium-ion battery electrodes using the Discrete Element Method (DEM) [PDF]

open access: yesEPJ Web of Conferences
The electrochemical performance of a lithium-ion battery is strongly influenced by the microstructure of its electrode. A dried electrode consists of the active material (AM) particles and carbon-binder domain (CBD) phase.
Tiwari Alok   +4 more
doaj   +1 more source

Enhanced reaction kinetics in biological cells

open access: yes, 2008
The cell cytoskeleton is a striking example of "active" medium driven out-of-equilibrium by ATP hydrolysis. Such activity has been shown recently to have a spectacular impact on the mechanical and rheological properties of the cellular medium, as well as
A Ajdari   +33 more
core   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Investigating the role that the Southern Ocean biological pump plays in determining global ocean oxygen concentrations and deoxygenation [PDF]

open access: yes, 2013
Global ocean circulation connects marine biogeochemical cycles through the long-range transport of nutrients and oxygen with the Southern Ocean (SO) acting as a water mass crossroads. The biological pump in the SO has been shown to play an important role
Keller, David, Oschlies, Andreas
core  

Dehydration and ionic conductance quantization in nanopores

open access: yes, 2010
There has been tremendous experimental progress in the last decade in identifying the structure and function of biological pores (ion channels) and fabricating synthetic pores.
Ashcroft F M   +9 more
core   +1 more source

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

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