Results 71 to 80 of about 1,751,937 (284)
A Cre‐dependent lentiviral vector for neuron subtype‐specific expression of large proteins
FEBS Letters, EarlyView.We designed a versatile and modular lentivector comprising a Cre‐dependent switch and self‐cleaving 2A peptide and tested it for co‐expression of GFP and a 2.8 kb gene of interest (GOI) in mouse cortical parvalbumin (PV+) interneurons and midbrain dopamine (TH+) neurons.
Weixuan Xue +6 more
wiley +1 more source
By dawn or dusk—how circadian timing rewrites bacterial infection outcomes
FEBS Letters, EarlyView.The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo +2 more
wiley +1 more source
Frontiers in ChemistryCalcium carbonate (CaCO3) is an incredibly abundant mineral on Earth, with over 90% of it being found in the lithosphere. To address the CO2 crisis and combat ocean acidification, it is essential to produce more CaCO3 using various synthetic methods ...
Jackson Comes +4 more
doaj +1 more source
An Energetic Variational Approach for ion transport
, 2014 The transport and distribution of charged particles are crucial in the study of many physical and biological problems. In this paper, we employ an Energy Variational Approach to derive the coupled Poisson-Nernst-Planck-Navier-Stokes system.
Liu, Chun, Sheng, Ping, Xu, Shixin
core +2 more sources
Ion transport through biological channels [PDF]
, 2015 The transport of ions across single-molecule protein nanochannels is important both in the biological context and in proposed nanotechnological applications.
Aguilella-Arzo, Marcel, Faraudo, Jordi
core +2 more sources
Hematopoietic (stem) cells—The elixir of life?
FEBS Letters, EarlyView.The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo +4 more
wiley +1 more source
Nanomaterials Designed for Antiviral Drug Delivery Transport across Biological Barriers
Pharmaceutics, 2020 Viral infections are a major global health problem, representing a significant cause of mortality with an unfavorable continuously amplified socio-economic impact.
Florina-Daniela Cojocaru +9 more
doaj +1 more source
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
A physical derivation of high-flux ion transport in biological channel via quantum ion coherence
Nature CommunicationsBiological ion channels usually conduct the high-flux transport of 107 ~ 108 ions·s− 1; however, the underlying mechanism is still lacking. Here, by applying the KcsA potassium channel as a typical example, and performing multitimescale molecular ...
Yue Wang +5 more
doaj +1 more source
Dehydration and ionic conductance quantization in nanopores
, 2010 There has been tremendous experimental progress in the last decade in identifying the structure and function of biological pores (ion channels) and fabricating synthetic pores.
Ashcroft F M +9 more
core +1 more source