Results 81 to 90 of about 6,267,247 (357)

FoxO1 signaling in B cell malignancies and its therapeutic targeting

FEBS Letters, EarlyView.
FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac, Petra Pavelkova, Laura Ondrisova, Marek Mraz   +3 more
wiley   +1 more source

Biological processes and links to the physics [PDF]

, 2009
Analysis of the temporal and spatial variability of biological processes and identification of the main variables that drive the dynamic regime of marine ecosystems is complex.
Alheit, Allain, Arnold, Aro, Baumann, Beaugrand, Borja, Brett, Browman, Campana, Campana, Cowan, deYoung, Dippner, Dower, Fiksen, Fonselius, Fortier, Fowler, Fromentin, Gallego, Hannah, Hans-Harald Hinrichsen, Hay, Heath, Heath, Hermann, Hermann, Hinckley, Hinckley, Hinrichsen, Hinrichsen, Hinrichsen, Hinrichsen, Hinrichsen, Hinrichsen, Houde, Houde, Hänninen, Iles, Kendall, Klein-Breteler, Klein-Breteler, Köster, Köster, Köster, Lehmann, Letcher, Levin, Limburg, Lough, Lough, Lynch, Lynch, MacKenzie, Mariani, Marshall, Matthäus, Munk, Möllmann, Möllmann, Neuenfeldt, Nissling, Otterlei, Ottersen, Ottersen, Painting, Pedersen, Petereit, Planque, Planque, Plante, Reid, Reid, Robichaud, Rose, Rose, Rothschild, Rothschild, Shaffer, Smith, Stephens, Turner, Voss, Voss, Voss, Werner, Werner, Wieland, Zeldis   +89 more
core   +1 more source

Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley   +1 more source

A multiscale description of growth and transport in biological tissues [PDF]

Theoretical and Applied Mechanics, 2007
We study a growing biological tissue as an open biphasic mixture with mass exchange between phases. The solid phase is identified with the matrix of a porous medium, while the fluid phase is comprised of water, together with all the dissolved chemical ...
Grillo A., Zingali G.Y., Borrello D.Y., Federico S.Z., Herzog W.Z., Giaquinta G.   +5 more
doaj   +1 more source

A FRAP model to investigate reaction-diffusion of proteins within a bounded domain: a theoretical approach

, 2008
Temporally and spatially resolved measurements of protein transport inside cells provide important clues to the functional architecture and dynamics of biological systems. Fluorescence Recovery After Photobleaching (FRAP) technique has been used over the
Axelrod, Beaudouin, Blonk, Braeckmans, Braga, Braga, Carmo-Fonseca, Carrero, Carrero, Carrero, Carslaw, Crank, Dundr, Edidin, George D. Tsibidis, Hinow, Houtsmuller, Jacobson, Jacques, Jacques, Jorge Ripoll, Koppel, Lele, Lippincott-Schwartz, Meyvis, Peters, Peters, Phair, Phair, Reits, Soumpasis, Sprague, Sprague, Sprague, Tang, Tardy, Th’ng, Wedekind, Wedekind, Weiss, White   +40 more
core   +1 more source

Making tau amyloid models in vitro: a crucial and underestimated challenge

FEBS Letters, EarlyView.
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley   +1 more source

Physical and biological controls on fine sediment transport and storage in rivers [PDF]

, 2018
Excess fine sediment, comprising particles
Casas-Mulet, R., England, Judy, Gittins, Joshua, Gurnell, Angela, Jones, Iwan, Mason, Richard, Mathers, Kate, Mckenzie, Morwenna, Murray-Bligh, John, Vanzo, D., Wilkes, Martin   +10 more
core   +3 more sources

Ion transport through biological channels

Contributions to science, 2015
The transport of ions across single-molecule protein nanochannels is important both in the biological context and in proposed nanotechnological applications. Here we discuss these systems from the perspective of non-equilibrium physics, and in particular, whether the concepts underlying the physics of diffusive and electrokinetic ...
Faraudo, Jordi, Aguilella Arzo, Marcel
openaire   +3 more sources

The intracellular domain of TLR2 is capable of high‐affinity Zn binding: possible outcomes for the receptor activation

FEBS Letters, EarlyView.
Toll‐like receptors (TLRs) are important in the innate immune system. This study explores the zinc‐binding ability of the TLR2 TIR domain (TLR2TIR). We found that TLR2TIR binds zinc with nanomolar affinity through its cysteine residues. Two of them, C673 and C713, are vital for receptor activation, indicating that zinc may play a role in initiating ...
Vladislav A. Lushpa, Cong Lin, Irina A. Talyzina, Marina V. Goncharuk, Eduard V. Bocharov, Alexander S. Arseniev, Xiaohui Wang, Sergey A. Goncharuk, Konstantin S. Mineev   +8 more
wiley   +1 more source

Enhanced reaction kinetics in biological cells

, 2008
The cell cytoskeleton is a striking example of "active" medium driven out-of-equilibrium by ATP hydrolysis. Such activity has been shown recently to have a spectacular impact on the mechanical and rheological properties of the cellular medium, as well as
A Ajdari, B Alberts, C Storm, C. Loverdo, D Holcman, D Mizuno, F Nedelec, FJ Nedelec, G Kolesov, H Salman, I Eliazar, J Howard, K Kruse, L Le Goff, M Coppey, M Slutsky, M. Moreau, MA Lomholt, MF Shlesinger, MF Shlesinger, MP Sheetz, O Berg, O Bénichou, O Bénichou, O Bénichou, O Thoumine, O. Bénichou, P Dalhaimer, R Voituriez, R Voituriez, R. Voituriez, S Condamin, S Huet, S Redner   +33 more
core   +1 more source