Results 241 to 250 of about 774,999 (361)

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Out-of-Pocket Spending for Biologic Drugs After Biosimilar Competition for Medicare Patients.

JAMA Netw Open
Riegler JS, Kesselheim AS, Rome BN.
europepmc   +1 more source

Infection Risk in Dermatology Patients Receiving Next-Generation Medication: A Meta-Analysis of JAK Inhibitors and Biologics. [PDF]

Medicina (Kaunas)
Gupta AK, Susmita, Economopoulos V.
europepmc   +1 more source

Electrospun Polycaprolactone-Curcumin Scaffolds: Optimization of fiber production for enhanced Nanotopography and improved biological cell adhesion

Orion Yoshikawa, Valentina Basoli, Francesco Boschetto, Alfredo Rondinella, Wenliang Zhu, Florian M. Thieringer, Huaizhong Xu, Elia Marin   +7 more
openalex   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Navigating challenges in management of difficult-to-treat chronic rhinosinusitis with nasal polyps in the greater Gulf. [PDF]

Saudi Med J
Marglani OA, Razzak Juratli A, Maatouq Alwael A, Hussain Alokby G, Al Rayyes HYA, Alsharif SAA, Abo El Ezz TA.   +6 more
europepmc   +1 more source

Biodeterioration of Cement and Cement–Polymer Mortars: Analysis of the Influence of the Structure and Distribution of Pores on the Humidity of Mortars Exposed to the Biological Environment [PDF]

Elżbieta Stanaszek-Tomal
openalex   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Pharmacological considerations for next-generation protein therapeutics in cardiovascular disease. [PDF]

J Pharmacol Exp Ther
Lin E, Momin N.
europepmc   +1 more source

Simple Synthesis and Biological Evaluation of Some Benzimidazoles Using Sodium Hexafluroaluminate, Na 3 AlF 6 , as an Efficient Catalyst.

, 2014
Akbar Mobinikhaledi, Ahmad Hamta‌, Mehdi Kalhor, Mehdi Shariatzadeh   +3 more
openalex   +1 more source