Results 21 to 30 of about 623,392 (272)
Engineering an anti-CD52 antibody for enhanced deamidation stability
mAbs, 2019 Deamidation evaluation and mitigation is an important aspect of therapeutic antibody developability assessment. We investigated the structure and function of the Asn-Gly deamidation in a human anti-CD52 IgG1 antibody light chain complementarity ...
Huawei Qiu +11 more
doaj +1 more source
Biologically generated turbulent energy cascade in shear flow depends on tensor geometry [PDF]
arXiv, 2023 It has been proposed that biologically generated turbulence plays an important role in material transport and ocean mixing. Both experimental and numerical studies have reported evidence of the non-negligible mixing by moderate Reynolds number swimmers in quiescent water, such as zooplankton, especially at aggregation scales.
arxiv
R-Mixup: Riemannian Mixup for Biological Networks [PDF]
, 2023 Biological networks are commonly used in biomedical and healthcare domains to effectively model the structure of complex biological systems with interactions linking biological entities. However, due to their characteristics of high dimensionality and low sample size, directly applying deep learning models on biological networks usually faces severe ...
arxiv +1 more source
Scientific Reports, 2021 An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Anushikha Thakur +11 more
doaj +1 more source
Scientific Reports, 2021 The development of reference standards for nanoparticle sizing allows for cross laboratory studies and effective transfer of particle sizing methodology. To facilitate this, these reference standards must be stable upon long-term storage.
Christian C. E. Luebbert +6 more
doaj +1 more source
Quantum mechanism of Biological Search [PDF]
, 2006 We wish to suggest an algorithm for biological search including DNA search. Our argument supposes that biological search be performed by quantum search.If we assume this, we can naturally answer the following long lasting puzzles such that "Why does DNA use the helix structure?" and "How can the evolution in biological system occur?".
arxiv +1 more source
Engineering solventogenic clostridia for commercial production of bio-chemicals
Engineering Biology, 2019 The manufacture of bio-chemicals through the use of microbial fermentation and renewable feedstock has a number of well-known advantages linked to sustainability and reduced impacts on the environment.
Nathan W. G. Fairhurst +5 more
doaj +1 more source
mAbs, 2020 Proline cis-trans conformational isomerization is a mechanism that affects different types of protein functions and behaviors. Using analytical characterization, structural analysis, and molecular dynamics simulations, we studied the causes of an ...
Alessandro Masiero +23 more
doaj +1 more source
“Stapling” scFv for multispecific biotherapeutics of superior properties
mAbs, 2023 Single-chain fragment variable (scFv) domains play an important role in antibody-based therapeutic modalities, such as bispecifics, multispecifics and chimeric antigen receptor T cells or natural killer cells.
Lauren E. Boucher +29 more
doaj +1 more source