Results 291 to 300 of about 739,943 (342)

Current trends in single‐cell RNA sequencing applications in diabetes mellitus

FEBS Open Bio, EarlyView.
Single‐cell RNA sequencing is a powerful approach to decipher the cellular and molecular landscape at a single‐cell resolution. The rapid development of this technology has led to a wide range of applications, including the detection of cellular and molecular mechanisms and the identification and introduction of novel potential diagnostic and ...
Seyed Sajjad Zadian, Khodakaram Jahanbin, Shekoofeh Nikooei, Marzieh Rostaminejad, Arezoo Rahimi, Pedram Abdizadeh, Behnam Alipoor   +6 more
wiley   +1 more source

Treatment Status for Generalized Pustular Psoriasis in Japanese Patients: A Retrospective Chart Review. [PDF]

Dermatol Ther (Heidelb)
Okubo Y, Okuyama R, Imafuku S, Tada Y, Yamanaka K, Sugiura K, Yamaguchi Y, Yasuda M, Sakamoto W, Saitoh M, Morita A, Study Investigators.   +11 more
europepmc   +1 more source

Earthing effects on mitochondrial function: ATP production and ROS generation

FEBS Open Bio, EarlyView.
In contrast to sham and naive controls, grounded mitochondria not only exhibit significantly enhanced energy production but also demonstrate a remarkable reduction in membrane potential and oxidative stress. This suggests a profound improvement in mitochondrial health, presenting a promising avenue for therapeutic interventions.
Cecilia Giulivi, Richard Kotz
wiley   +1 more source

Real-World Treatment Patterns Among Pediatric and Adult Patients with Crohn's Disease in the United States. [PDF]

Drugs Real World Outcomes
Kastl A, Gibble TH, Tinsley D, Crandall WV, Komocsar WJ, Du Y, Choong CK, Jha P, Chan WMM.   +8 more
europepmc   +1 more source

An efficient strategy for producing RNA‐free Nucleocapsid protein of SARS‐CoV‐2 for biochemical and structural investigations

FEBS Open Bio, EarlyView.
Cleavable N‐terminal Thioredoxin fusion enabled soluble expression and purification of otherwise insoluble SARS‐CoV‐2 Nucleocapsid (N) protein. A four‐step purification strategy yielded highly homogeneous, RNA‐free N protein. Binding assays showed high RNA affinity (Kd ~ 28 nm). The study will facilitate high‐resolution structural studies of N protein,
Shweta Singh, Gagan D. Gupta
wiley   +1 more source

HP Newsletter June 2009 Download Full PDF [PDF]

, 2009

core   +1 more source

Severe Paediatric Asthma Collaborative in Europe: real-world data on children on biologics. [PDF]

ERJ Open Res
Liu NM, Pijnenburg MW, Deschildre A, de Mir-Messa I, Adalen S, Amat F, Antonino L, Biermé P, Bravo-Lopez M, Carlsen KCL, Carraro S, Cros P, Delestrain C, Diaz Garcia C, Epaud R, Fenu G, Ferraro VA, Fleming L, Hanssens L, Heine A, Labouret G, Leoni MC, Licari A, Lombardi E, Lopez Neyra A, Marguet C, Mazenq J, Pérez Tarazona S, Díaz JCR, Schweitzer C, Spada E, Valverde Molina J, Verhulst S, Wanin S, Rusconi F.   +34 more
europepmc   +1 more source

Analysis of the regulation of undecaprenyl diphosphate dephosphorylation in Escherichia coli

FEBS Open Bio, EarlyView.
BacA, PgpB, and YbjG phosphatases are involved in undecaprenyl phosphate (C55P) synthesis in Escherichia coli. We analyzed the lipid contents and the gene expression in the gene‐disruption strains. Undecaprenyl diphosphate (C55PP) level increased in the bacA, ybjG double‐disruption strain, but C55P levels were similar in all strains.
Tomotaka Jitsukawa, Yasushi Shigeri, Shingo Fujisaki   +2 more
wiley   +1 more source

Biosimilars versus biological therapy in inflammatory bowel disease: challenges and targeting strategies using drug delivery systems. [PDF]

Clin Exp Med
Aljabri A, Soliman GM, Ramadan YN, Medhat MA, Hetta HF.   +4 more
europepmc   +1 more source

Matrix: a complex amalgam of structures and functions in tumor microenvironment

FEBS Open Bio, EarlyView.
The matrix is a dynamic, intricate three‐dimensional mesh of biomolecules with both structural and functional properties. This review deals with the complexity of this ‘molecular amalgam’ in the tumor microenvironment and highlights its importance in the maintenance and evolution of tumors by describing certain matrix biomolecules, such as ...
Spyros S. Skandalis, Evgenia Tsoukala, Theodora D. Sarantopoulou, Maria‐Elpida Christopoulou   +3 more
wiley   +1 more source