Results 51 to 60 of about 3,349,315 (392)

Profile of reslizumab in eosinophilic disease and its potential in the treatment of poorly controlled eosinophilic asthma [PDF]

, 2013
Peer reviewedPublisher ...
Walsh, Garry Michael
core   +2 more sources

Engineering solventogenic clostridia for commercial production of bio-chemicals

Engineering Biology, 2019
The manufacture of bio-chemicals through the use of microbial fermentation and renewable feedstock has a number of well-known advantages linked to sustainability and reduced impacts on the environment.
Nathan W. G. Fairhurst, Rachel A. Harper, Holly K. Smith, Lee C. Speight, Joseph S. Clements II, Elizabeth R. Jenkinson   +5 more
doaj   +1 more source

Japanese guidance for use of biologics for psoriasis (the 2019 version)

Journal of dermatology (Print), 2020
As the first biologics for psoriasis in Japan, infliximab and adalimumab, anti‐tumor necrosis factor‐α antibodies, became available in the field of dermatology in 2010, followed by ustekinumab, an anti‐interleukin (IL)‐12/IL‐23p40 antibody, which was ...
H. Saeki, T. Terui, A. Morita, S. Sano, S. Imafuku, A. Asahina, M. Komine, T. Etoh, A. Igarashi, H. Torii, M. Abe, H. Nakagawa, A. Watanabe, H. Yotsuyanagi, M. Ohtsuki   +14 more
semanticscholar   +1 more source

Influence of bound dodecanoic acid on the reconstitution of albumin nanoparticles from a lyophilized state

Scientific Reports, 2021
The development of reference standards for nanoparticle sizing allows for cross laboratory studies and effective transfer of particle sizing methodology. To facilitate this, these reference standards must be stable upon long-term storage.
Christian C. E. Luebbert, Rola Mansa, Raisa Rahman, Zygmunt J. Jakubek, Grant E. Frahm, Shan Zou, Michael J. W. Johnston   +6 more
doaj   +1 more source

The impact of proline isomerization on antigen binding and the analytical profile of a trispecific anti-HIV antibody

mAbs, 2020
Proline cis-trans conformational isomerization is a mechanism that affects different types of protein functions and behaviors. Using analytical characterization, structural analysis, and molecular dynamics simulations, we studied the causes of an ...
Alessandro Masiero, Lechat Nelly, Gentric Marianne, Sourrouille Christophe, Laville Florian, Crépin Ronan, Borel Claire, Ziegler Cornelia, Bisch Grégoire, Leclerc Eric, Laurent Ludovic, Brault Dominique, Alexandre Sylvie, Gagnaire Marie, Duffieux Francis, Soubrier Fabienne, Capdevila Cécile, Arnould Isabelle, Dumas Jacques, Dabin Jérôme, Genet Bruno, Radošević Katarina, Menet Jean-Michel, Prades Catherine   +23 more
doaj   +1 more source

Disease activity and biologic use in patients with psoriatic arthritis or rheumatoid arthritis. [PDF]

, 2018
To compare disease burden and biologic use among psoriatic arthritis (PsA) or rheumatoid arthritis (RA) patients recruited to the Corrona registry. Retrospective study of patients with PsA or RA enrolled in Corrona between January 2002 and March 2013 and
Etzel, Carol J, Greenberg, Jeffrey D, Griffith, Jenny, Karki, Chitra, Kavanaugh, Arthur, Kremer, Joel M, Singh, Rakesh   +6 more
core   +1 more source

“Stapling” scFv for multispecific biotherapeutics of superior properties

mAbs, 2023
Single-chain fragment variable (scFv) domains play an important role in antibody-based therapeutic modalities, such as bispecifics, multispecifics and chimeric antigen receptor T cells or natural killer cells.
Lauren E. Boucher, Elisabeth Geyer Prinslow, Michael Feldkamp, Fang Yi, Rupesh Nanjunda, Sheng-Jiun Wu, Tun Liu, Eilyn R. Lacy, Steven Jacobs, Natalia Kozlyuk, Brian Del Rosario, Bingyuan Wu, Patricia Aquino, Robert C. Davidson, Samantha Heyne, Nicholas Mazzanti, James Testa, Michael D. Diem, Elsa Gorre, Andrew Mahan, Hirsh Nanda, Harsha P. Gunawardena, Alexis Gervais, Anthony A. Armstrong, Alexey Teplyakov, Chichi Huang, Adam Zwolak, Partha Chowdhury, Wan Cheung Cheung, Jinquan Luo   +29 more
doaj   +1 more source

Analysis of biopharma raw materials by electrophoresis microchips with contactless conductivity detection [PDF]

, 2009
Detailed information concerning the composition of the raw materials employed in the production of biologics is important for the efficient control and optimization of bioprocesses.
Benito-Lopez, Fernando, Diamond, Dermot, Garcia-Cordero, Jose L., Ricco, Antonio J., Vázquez, Mercedes   +4 more
core  

Psoriasis Area and Severity Index response in moderate-severe psoriatic patients switched to adalimumab: results from the OPPSA study [PDF]

, 2018
Background: Few studies have compared the efficacy of switching to adalimumab in the real-life setting in plaque psoriasis patients. Objective: To evaluate the effect of adalimumab in psoriasis patients previously treated with other biologics.
Armesto, Burmester, Carrera, Davison, Edson-Heredia, Elm, Gisondi, Gisondi, Gisondi, Gordon, Gossec, Gossec, Gottlieb, Griffiths, Gupta, Honda, Kurd, Lernia, Lernia, López-Ferrer, Lümig, Menter, Menter, Menter, Mrowietz, Nestle, Ortonne, Papoutsaki, Papp, Papp, Papp, Papp, Salvarani, Sbidian, Simone, Strober, Talamonti, Talamonti, Talamonti, Vandenbroucke, Vollenhoven   +40 more
core   +1 more source

Combining transient dynamics and logistic‐asymptotic growth to study the recovery of two seabird populations after rat eradication

Population Ecology, EarlyView.
This study examines the demographic dynamics of two seabird populations on Tromelin Island, 15 years after the eradication of brown rats. The results indicate that these populations are in good health and are expected to continue growing until breeding sites are saturated in about a century.
Merlène Saunier, Christophe Barbraud, Maxime Amy, Sabine Orlowski, Jean Hivert, Gabrielle Dicque, Matthieu Le Corre   +6 more
wiley   +1 more source