Results 101 to 110 of about 7,174,703 (396)
FEBS Letters, EarlyView.At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom +3 more
wiley +1 more source
Robust H∞ feedback control for uncertain stochastic delayed genetic regulatory networks with additive and multiplicative noise [PDF]
, 2010 The official published version can found at the link below.Noises are ubiquitous in genetic regulatory networks (GRNs). Gene regulation is inherently a stochastic process because of intrinsic and extrinsic noises that cause kinetic parameter variations ...
Du, M, Gao, H, Li, Y, Pan, W, Wang, Z
core +1 more source
β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source
, 2020 Even if the topics are abstract in biology education, they are very suitable for association to daily life. The context-based learning approach is one of the approaches that is student-centered and provides a connection between daily life and scientific ...
B. G. Cabbar, H. Senel
semanticscholar +1 more source
The relationship between biological function and teleology: Implications for biology education
Evolution: Education and Outreach, 2020 This paper explicates the relationship between biological function and teleology by focusing not only on difference but also on conceptual overlap. By doing so, this paper is meant to increase awareness of the misleading potential of biological function ...
Friederike Trommler, M. Hammann
semanticscholar +1 more source
Molecular Oncology, EarlyView.AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou +5 more
wiley +1 more source
Application of Biotechnology to Solve Relevant Biological Problems Promotes Understanding of Underlying Concepts [PDF]
, 2001 Although some efforts have been made to modify the curriculum of the Introductory Biology laboratories from a passive to a more experimental form, the use of modern biotechnology had not been implemented at our institution.
Burrowes, P. A., Nazario, G. M.
core +1 more source
Molecular Oncology, EarlyView.PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham +21 more
wiley +1 more source
Molecular Oncology, EarlyView.This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan +9 more
wiley +1 more source
CBE - Life Sciences Education, 2019 Understanding how students develop biology interests and the roles interest plays in biology contexts could help instructors and researchers to increase science, technology, engineering, and mathematics students’ motivation and persistence.
Ashley A. Rowland +3 more
semanticscholar +1 more source