Results 191 to 200 of about 7,174,703 (396)
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
The Metamorphosing Professor: Adapting Teaching to Fulfill the Promise of Biology Education. [PDF]
Integr Comp Biol, 2022 García-Ojeda ME, Nishiguchi MK.
europepmc +1 more source
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
Correction: Integrating tropical research into biology education is urgently needed. [PDF]
PLoS Biol, 2022 Russell AE +17 more
europepmc +1 more source
GENETİK KONUSUNA AİT KAVRAMLARIN FARKLI ÖĞRENCİ SEVİYELERİNE GÖRE DEĞİŞİMİ
Sakarya Üniversitesi Eğitim Fakültesi Dergisi, 2013 Kavramlar insanlarÕn düúünce sisteminde yer alan soyut birimlerdir. Bilgileri sÕnÕflandÕrmak suretiyle insanlar arasÕ iletiúimi kolaylaútÕrÕrlar. YapÕlan çalÕúmalar ö÷rencilerin bilimsel kavramlarÕ okulda ö÷renmelerine ra÷men do÷al olaylar hakkÕnda daha ...
Arzu Saka
doaj
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Basic biology education in high school and acceptance of genetically modified food in Japan. [PDF]
PLoS One, 2023 Mine A +4 more
europepmc +1 more source