Results 71 to 80 of about 1,431,950 (311)
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Negative Energy: Why Interdisciplinary Physics Requires Multiple Ontologies
, 2013 Much recent work in physics education research has focused on ontological metaphors for energy, particularly the substance ontology and its pedagogical affordances.
Dreyfus, Benjamin W. +5 more
core +1 more source
Fun, fear, and frustration: Experiences and opportunities in the classroom [PDF]
, 2016 In lieu of an abstract, here is the article\u27s first paragraph: As the outreach and special collections librarian at a small liberal arts college, I also serve as the liaison to the Wegmans School of Nursing, the Wegmans School of Pharmacy, and the ...
Price, Michelle
core +2 more sources
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Science Education International, 2019 Although fundamental chemistry acts as a prerequisite for fully comprehending imperative aspects of biology, Bielefeld University is one of three universities in North Rhine-Westphalia, Germany that does not require majors or minors in biology education ...
Claas Wegner +2 more
doaj +1 more source
Robust H∞ feedback control for uncertain stochastic delayed genetic regulatory networks with additive and multiplicative noise [PDF]
, 2010 The official published version can found at the link below.Noises are ubiquitous in genetic regulatory networks (GRNs). Gene regulation is inherently a stochastic process because of intrinsic and extrinsic noises that cause kinetic parameter variations ...
Du, M, Gao, H, Li, Y, Pan, W, Wang, Z
core +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
N.C. Medicaid Reform: A Bipartisan Path Forward [PDF]
, 2017 The North Carolina Medicaid program currently constitutes 32% of the state budget and provides insurance coverage to 18% of the state’s population. At the same time, 13% of North Carolinians remain uninsured, and even among the insured, significant ...
Rice, Allison, Richman, Barak D.
core +1 more source
Molecular Oncology, EarlyView.We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source
2011-2012 Arkansas Test Results [PDF]
, 2012 On Monday, July 30, the Arkansas Department of Education (ADE) released the 2011-2012 test score results. The following brief will highlight the results of these tests, compare achievement scores over time, and provide a glimpse of regional achievement ...
Greenwood, Reed, Ritter, Gary W.
core +2 more sources