Results 51 to 60 of about 440,164 (268)
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Cogent EducationA core element of teacherss' professional knowledge is their Pedagogical Content Knowledge (PCK). The Refined Consensus Model of PCK defines three realms of PCK: collective PCK, personal PCK and enacted PCK.
Marie Irmer +2 more
doaj +1 more source
Science Education International, 2019 Although fundamental chemistry acts as a prerequisite for fully comprehending imperative aspects of biology, Bielefeld University is one of three universities in North Rhine-Westphalia, Germany that does not require majors or minors in biology education ...
Claas Wegner +2 more
doaj +1 more source
BIOLOGY AND PHYSICAL EDUCATION 3 [PDF]
AJN, American Journal of Nursing, 1903 n ...
openaire +2 more sources
Education in Computational Biology Today and Tomorrow
PLoS Computational Biology, 2013 The etymology of the word “education” in Wikipedia is enlightening: “a rearing” and “I lead forth” (http://en.wikipedia.org/wiki/Education#Etymology). Computational biology educators are leading and raising the next generation of scientists and, in doing so, are in need of new tools, methods, and approaches.
Joanne A. Fox, B. F. Francis Ouellette
openaire +4 more sources
Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source
Biology Education Is Evolution Education
The American Biology Teacher, 2016 Some mark the passage of time with birthdays, holiday seasons, the New Year, the end or start of school, and myriad other personally relevant and noteworthy events. At The American Biology Teacher we are pleased to continue the tradition started by my predecessor with a theme issue each February to honor the birth of Charles Darwin, paying particular ...
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The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source