Results 101 to 110 of about 5,448,839 (367)
GOexpress: an R/Bioconductor package for the identification and visualisation of robust gene ontology signatures through supervised learning of gene expression data [PDF]
, 2016 Background: Identification of gene expression profiles that differentiate experimental groups is critical for discovery and analysis of key molecular pathways and also for selection of robust diagnostic or prognostic biomarkers.
Gordon, SV +7 more
core +4 more sources
Making tau amyloid models in vitro: a crucial and underestimated challenge
FEBS Letters, EarlyView.This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley +1 more source
BMC Systems Biology, 2015 BackgroundDevelopment of human cancer can proceed through the accumulation of different genetic changes affecting the structure and function of the genome.
C. Cava, G. Bertoli, I. Castiglioni
semanticscholar +1 more source
Optimal Rate of Direct Estimators in Systems of Ordinary Differential Equations Linear in Functions of the Parameters [PDF]
, 2015 Many processes in biology, chemistry, physics, medicine, and engineering are modeled by a system of differential equations. Such a system is usually characterized via unknown parameters and estimating their 'true' value is thus required. In this paper we
Dattner, Itai, Klaassen, Chris A. J.
core +2 more sources
FEBS Letters, EarlyView.α2 → 8 polysialic acid elicits poor immunogenicity. Small‐angle scattering shows a supramolecular structure with parallel‐chain binding, although in different forms at μm and mm calcium. The major histocompatibility complex requires molecular weights around 2000 Da to produce antibodies, and 2000 Da polysialic oligomers will bind in these structures ...
Kenneth A. Rubinson
wiley +1 more source
Scientific ReportsAging-related biochemical changes in nerve cells lead to dysfunctional synapses and disrupted neuronal circuits, ultimately affecting vital processes such as brain plasticity, learning, and memory.
Aleksandra Gawryluk +6 more
doaj +1 more source
Microfluidics for understanding model organisms
Nature Communications, 2022 Building small-scale tools for biology research eliminates the need for time-consuming methods and enables novel experimental paradigms. Here, the authors discuss microfluidics' potential for manipulating or stimulating model organisms and identify ...
Nolan Frey +3 more
doaj +1 more source
Computing Pathways to Systems Biology: Key Contributions of Computational Methods in Pathway Identification [PDF]
arXiv, 2013 Understanding large molecular networks consisting of entities such as genes, proteins or RNAs that interact in complex ways to drive the cellular machinery has been an active focus of systems biology. Computational approaches have played a key role in systems biology by complementing theoretical and experimental approaches.
arxiv
Visualizing Genomic Data [PDF]
, 2006 The advent of experimental techniques capable of probing biomolecules and cells at high levels of resolution has led to a rapid change in the methods used for the analysis of experimental molecular biology data.
Gentleman, Robert +2 more
core +1 more source
Lactococcus garvieae: a small bacteria and a big data world [PDF]
, 2015 OBJECTIVE: To describe the importance of bioinformatics tools to analyze the big data yielded from new "omics" generation-methods, with the aim of unraveling the biology of the pathogen bacteria Lactococcus garvieae.
Alicia Gibello +7 more
core +4 more sources