Results 101 to 110 of about 2,458,031 (313)

Is the Cell Really a Machine? [PDF]

, 2019
It has become customary to conceptualize the living cell as an intricate piece of machinery, different to a man-made machine only in terms of its superior complexity.
Nicholson, Daniel J.
core  

Acceleration Profiles and Processing Methods for Parabolic Flight

, 2017
Parabolic flights provide cost-effective, time-limited access to "weightless" or reduced gravity conditions experienced in space or on planetary surfaces, e.g. the Moon or Mars.
Bhattaru, Srinivasa A., Bryan, Noelle C., Carr, Christopher E., Ruvkun, Gary, Saboda, Kendall N., Zuber, Maria T.   +5 more
core   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Does replication groups scoring reduce false positive rate in SNP interaction discovery? [PDF]

, 2010
BACKGROUNG. Computational methods that infer single nucleotide polymorphism (SNP) interactions from phenotype data may uncover new biological mechanisms in non-Mendelian diseases. However, practical aspects of such analysis face many problems.
Curk, Tomaz, Demsar, Janez, Toplak, Marko, Zupan, Blaz   +3 more
core  

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Chemical Biology Gateways to Mapping Location, Association, and Pathway Responsivity

Frontiers in Chemistry, 2019
Here we discuss, how by applying chemical concepts to biological problems, methods have been developed to map spatiotemporal regulation of proteins and small-molecule modulation of proteome signaling responses.
Marcus J. C. Long, Xuyu Liu, Yimon Aye
doaj   +1 more source

Systems Biology and the Development of Vaccines and Drugs for Malaria Treatments [PDF]

, 2006
The sequencing race has ended and the functional race has already begun. Microarray technology enables simultaneous gene expression analysis of thousands of genes, enabling a snapshot of an organisms’ transcriptome at an unprecedented resolution.
Adebiyi, E. F.
core   +1 more source

Cell density–dependent nuclear‐cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1‐mediated transcription

FEBS Letters, EarlyView.
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom, Jaewoong Jang, Jung Sun Park, Yong‐Kook Kang   +3 more
wiley   +1 more source

THE EFFECTIVENESS OF THE APPLICATION OF THE METHODOLOGY OF PROJECT-BASED LEARNING IN GENERAL BIOLOGY IN THE FORMATION OF STUDENTS' SUBJECT AND META-SUBJECT COMPETENCIES

Russian Journal of Education and Psychology
Background. The system-activity approach as the methodological basis of modern educational standards has determined the need to involve schoolchildren in project activities at all levels of general education in accordance with the principle of continuity
Andzhelika M. Shekhmirzova, Lyudmila V. Gribina, Fatima A. Tuguz, Nafiset S. Blagoz   +3 more
doaj   +1 more source