Results 231 to 240 of about 2,453,647 (296)

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

open access: yesFEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada   +5 more
wiley   +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

open access: yesFEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida   +6 more
wiley   +1 more source

Metabolic rate measurements of two benthic invertebrates under simulated climate change conditions. [PDF]

open access: yesBiodivers Data J
Grigoriou P   +5 more
europepmc   +1 more source

A comparative study of organoid-derived and cell line-derived intestinal epithelial models. [PDF]

open access: yesPLoS One
Asal M   +5 more
europepmc   +1 more source

A multi-way SMILES-based hypergraph inference network for metabolic model reconstruction. [PDF]

open access: yesCommun Biol
Zhao Y   +8 more
europepmc   +1 more source

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