Results 61 to 70 of about 19,142,092 (295)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Designing and Implementation of the Blended Instructional Model Based on Reigeluth, Merrill, Keller and the Investigation of Its Effect on Students’ Learning in Biology Course [PDF]

Interdisciplinary Journal of Virtual Learning in Medical Sciences, 2015
Introduction Instruction and learning play an important role in the twenty-first century which has been named the knowledge society and knowledge economy.
Mohammad Shahalizadeh, Mohammad Hassan Amirteimoury, Esmaeil Zaraii Zavaraki   +2 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

VARIABILITY IN SENSORY ECOLOGY: EXPANDING THE BRIDGE BETWEEN PHYSIOLOGY AND EVOLUTIONARY BIOLOGY [PDF]

, 2009
International audienceSensory organs represent the interface between the central nervous system of organisms and the environment in which they live.
Irschick, Duncan, Lars Chittka, Dangles, O, Chittka, Lars, Irschick, D, Chittka, L, Olivier Dangles, Duncan Irschick, Casas, J, Dangles, Olivier, Casas, Jérome, Jérôme Casas   +11 more
core   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Can methods applied in medicine be used to summarize and disseminate conservation research? [PDF]

, 2004
To ensure that the best scientific evidence is available to guide conservation action, effective mechanisms for communicating the results of research are necessary.
Lindenmayer, David B, Lindenmayer, D B, Maindonald, J, Salisbury, Janet G, Ioan Fazey, Robert Douglas, Fazey, Ioan, Janet G. Salisbury, David B. Lindenmayer, Douglas, R, Fazey, Ioan Raymond Albert, Maindonald, John, Salisbury, J G, Douglas, Robert, John Maindonald, Douglas, Robert M   +15 more
core   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Categorical data analysis in experimental biology [PDF]

, 2010
The categorical data set is an important data class in experimental biology and contains data separable into several mutually exclusive categories. Unlike measurement of a continuous variable, categorical data cannot be analyzed with methods such as the ...
Xu, Bo, Feng, Xuyan, Rebecca D. Burdine, Bo Xu, Xuyan Feng, Burdine, Rebecca D.   +5 more
core   +1 more source