Results 61 to 70 of about 2,476,127 (290)
AlphaFold and the future of structural biology
IUCrJ, 2023 This editorial acknowledges the transformative impact of new machine-learning methods, such as the use of AlphaFold, but also makes the case for the continuing need for experimental structural biology.
Randy J. Read +4 more
doaj +1 more source
Evolving methods for rational de novo design of functional RNA molecules
, 2019 Artificial RNA molecules with novel functionality have many applications in synthetic biology, pharmacy and white biotechnology. The de novo design of such devices using computational methods and prediction tools is a resource-efficient alternative to ...
Findeiß, Sven +3 more
core +1 more source
Heterogeneity in pure microbial systems: experimental measurements and modeling [PDF]
, 2017 Cellular heterogeneity influences bioprocess performance in ways that until date are not completely elucidated. In order to account for this phenomenon in the design and operation of bioprocesses, reliable analytical and mathematical descriptions are ...
González-Cabaleiro, Rebeca +4 more
core +2 more sources
Pediatric Blood &Cancer, EarlyView.ABSTRACT Immune effector cell‐associated hemophagocytic lymphohistiocytosis‐like syndrome (IEC‐HS) is a life‐threatening hyperinflammatory toxicity distinct from cytokine release syndrome (CRS) and neurotoxicity following chimeric antigen receptor T‐cell (CAR‐T) therapy. In a single‐institution retrospective cohort of pediatric and young adult patients
Thomas J. Galletta +6 more
wiley +1 more source
Experimental design for parameter estimation of gene regulatory networks. [PDF]
PLoS ONE, 2012 Systems biology aims for building quantitative models to address unresolved issues in molecular biology. In order to describe the behavior of biological cells adequately, gene regulatory networks (GRNs) are intensively investigated.
Bernhard Steiert +3 more
doaj +1 more source
Typology and specificity of biology philosophical problems
Семиотические исследования, 2023 The article examines a new complexity problem of ontology brought to life by technical interventions in living systems. The object is the philosophical problems of biology, the subject of the research is to identify the specifics and typology of the ...
Valentina E. Rednikina +1 more
doaj +1 more source
Parameter estimation and inference for stochastic reaction-diffusion systems: application to morphogenesis in D. melanogaster [PDF]
, 2010 Background: Reaction-diffusion systems are frequently used in systems biology to model developmental and signalling processes. In many applications, count numbers of the diffusing molecular species are very low, leading to the need to explicitly model ...
Dewar, M.A. +3 more
core +4 more sources
The Role of Hematopoietic Cell Transplantation in Ataxia‐Telangiectasia
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Ataxia‐telangiectasia (A‐T) is a DNA repair disorder characterized by neurodegeneration, immunodeficiency, and cancer predisposition. Hematopoietic cell transplantation (HCT) is an established therapy in related disorders such as Fanconi anemia (FA) and Nijmegen breakage syndrome (NBS), but its role in A‐T is unclear.
Laila Alkhouli +3 more
wiley +1 more source
Inferring Biologically Relevant Models: Nested Canalyzing Functions [PDF]
, 2010 Inferring dynamic biochemical networks is one of the main challenges in systems biology. Given experimental data, the objective is to identify the rules of interaction among the different entities of the network.
Hinkelmann, Franziska +1 more
core +3 more sources
Therapeutic Apheresis and Dialysis, EarlyView.ABSTRACT Introduction Pre‐dilution online hemodiafiltration (Pre‐HDF) is predominantly used in Japan, whereas post‐dilution online HDF (Post‐HDF) is more common in Europe. An asymmetric cellulose triacetate (ATA) membrane may improve biocompatibility.
Kenji Sakurai +4 more
wiley +1 more source