Results 131 to 140 of about 60,261 (259)

Repurposing a Small Molecule Plant Hormone as a Tunable ON‐Switch for CAR‐T Cell Immunotherapy

Advanced Science, EarlyView.
By engineering a receptor system integrating the plant auxin receptor AFB1 with its co‐receptor IAA7, we enable ligand‐dependent interactions triggered by the plant hormone auxins. This design allows rapid, reversible, and dose‐dependent T cell activation, resulting in potent cytotoxicity against B‐cell lymphoma in vitro and in vivo.
Hongxiang Zeng, Lei Zheng, Rongkun Tao, Sirui Zheng, Yanke Zhong, Yongxia Niu, Peng Zhang, Xiang Ma, Chen Yang, Min Zhang, Fuyu Duan, Jing Yang, Xuan Wei, Xiang Zhou, Zhenbiao Yang, Zhaoxi Sun, Qizhou Lian   +16 more
wiley   +1 more source

Bioluminescence [PDF]

, 2020
openaire   +2 more sources

Development and Evaluation of Exosporium-Anchored Bioluminescent and Fluorescent Reporters for Tracking <i>Clostridioides difficile</i> Spores Formed <i>In Vivo</i>. [PDF]

ACS Synth Biol
Lopez-Garcia OK, Hejtmancik T, Pizarro-Guajardo M, Brehm L, Brito-Silva C, Paredes-Sabja D.   +5 more
europepmc   +1 more source

Metabolic Reprogramming in Glioblastoma Stem Cells Promotes Radiation Resistance Through a H3K18la/USP30/MBOAT2 Axis

Advanced Science, EarlyView.
LDHA‐driven lactate production in mesenchymal glioma stem cells promotes p300‐dependent H3K18 lactylation, activates USP30 transcription, and stabilizes MBOAT2 to remodel phosphatidylethanolamines toward ferroptosis‐resistant PE‐MUFA species. Disrupting this metabolic–epigenetic–lipid circuit enhances ferroptosis and sensitizes glioblastoma to ...
Zong Miao, Wei Gu, Yimin Ren, Chenfei Lu, Wanzhi Cai, Junnan Lu, Zhongyuan Bao, Yanan Zhou, Rong Li, Ke Jin, Chao Chen, Hongxiang Wang, Lei Xu, Juxiang Chen   +13 more
wiley   +1 more source

Antho-RFamide effect on light production in the bioluminescent sea pen Pennatula phosphorea (Octocorallia, Pennatulacea). [PDF]

J Exp Biol
Duchatelet L, Flammang P, Dupont S, Mallefet J.   +3 more
europepmc   +1 more source

Recapitulating In Vivo Pharmacokinetics and Size‐Dependent Nanomedicine Delivery in a Microfluidic Platform

Advanced Science, EarlyView.
A microfluidic tumor platform integrates pharmacokinetic flow control, vascular‐like barriers, and 3D tumor spheroids to emulate in vivo drug exposure. The system reproduces dynamic concentration–time profiles and enables size‐dependent nanoparticle transport and efficacy evaluation, providing a predictive framework for assessing nanomedicine ...
Su Jeong Kang, Moon Sup Yoon, Jae Min Lee, Min Jeong Jo, Chae Eun Jin, Dae Hwan Shin   +5 more
wiley   +1 more source

ATP Bioluminescence Feedback Is Associated with Reduced Residual Hand Contamination Among Healthcare Workers: A Single-Center Before-and-After Study. [PDF]

Healthcare (Basel)
Pruna ED, Varga NI, Suba MI, Buleu F, Demeter I, Mot MD, Davidescu L, Pantilimonescu TF, Horhat FG.   +8 more
europepmc   +1 more source

From anthelmintic to neuro‐oncology: A systematic review of mebendazole repurposing for brain tumour therapy

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Mebendazole (MBZ), a benzimidazole anthelmintic with established clinical use, has emerged as a repurposing candidate for primary brain tumours due to its multimodal anticancer actions and central nervous system penetrance. This systematic review synthesizes preclinical and clinical evidence evaluating MBZ's efficacy, mechanisms of action ...
Ciara B. Blum, Milli McMenamin, Tessa Khoo, John M. Edwin, Prathibha Jose, Liam A. O’Callaghan   +5 more
wiley   +1 more source

Preventive and therapeutic efficacy of mRNA/LNP vaccines encoding HPV16 E6 and E7 in an early-intervention HPV tumor mouse models. [PDF]

Hum Vaccin Immunother
Saithong S, Prompetchara E, Ketloy C, Khawsang C, Tharakhet K, Kaewpang P, Yostrerat N, Wangsoontorn P, Charsangbong K, Lam K, Heyes J, Weissman D, Ruxrungtham K.   +12 more
europepmc   +1 more source

BODIPY‐based J‐aggregates: From supramolecular chemistry to NIR bioimaging and phototherapies

Bulletin of the Korean Chemical Society, EarlyView.
BODIPY dyes form ordered J‐aggregates through controlled supramolecular self‐assembly, producing narrow, red‐shifted absorption bands with small Stokes shifts. This review highlights design strategies governing J‐aggregation, structure–property relationships, and applications in sensing, bioimaging, and phototherapy, guiding functional BODIPY‐based ...
Pooja Sharma, Yeonkyeong Lee, Youngmi Kim   +2 more
wiley   +1 more source