Results 221 to 230 of about 113,231 (318)

Engineered CAR‐NKT Extracellular Vesicles Suppress Tumor Progression and Enhance Antitumor Immunity

Advanced Science, EarlyView.
TM4SF1‐nanobody engineered CAR‐natural killer T–derived extracellular vesicles (CARTM4SF1‐EVs) provide a cell‐free alternative to CAR‐NKT therapy, achieving potent, targeted antitumor activity with reduced toxicity. CARTM4SF1‐EVs induce immunogenic cell death, remodel the tumor microenvironment, and enhance CD8⁺ T‐cell antitumor immunity.
Xiaopei Hao, Chengming Qu, Yanzhao Zhou, Xiaoqian Wang, Xiangjun Qian, Xun Chen, Feng Han, Xiaokai Zhang, Yiyi Ji, Han Li, ChengWei Ju, Peng Xia, Weiwei Tang, Hao Zhuang, Jinxue Zhou   +14 more
wiley   +1 more source

Low temperature abolishes human cellular circadian rhythm through Hopf bifurcation. [PDF]

NPJ Syst Biol Appl
Xiao Y, Sainoo Y, Nishimura T, Ito H.
europepmc   +1 more source

ROS‐Responsive Wedelolactone Hydrogel Promotes Intervertebral Disc Repair by Disrupting the NF‐κB–LCN2 Inflammatory Feedback Loop

Advanced Science, EarlyView.
A mechanically robust, ROS‐responsive hydrogel is engineered to treat intervertebral disc degeneration by targeting the NF‐κB–LCN2 inflammatory feedback loop. By delivering wedelolactone specifically within oxidative niches, this system disrupts macrophage–disc cell crosstalk.
Zimei Wu, Yan Xu, Lang Qin, Zemin Ling, Yingjie Mai, Xiong Tian Guo, Jiajia Chen, Leping Yan, Lin Wang, Liming Bian, Fuxin Wei   +10 more
wiley   +1 more source

Temperature changes are signaled in cyanobacteria through the PipX interaction network. [PDF]

Front Microbiol
Llop A, Bibak S, Mata-Balaguer T, Tremiño L, Fuertes-García L, Neira JL, Dixon R, Contreras A.   +7 more
europepmc   +1 more source

Spatial heterogeneity of the bioluminescence field of the tropical Atlantic Ocean and its relationship with internal waves [PDF]

, 1997
Vladimir Kushnir, Yu. N. Tokarev, R. Williams, Sergey Piontkovski, П. В. Евстигнеев   +4 more
openalex   +1 more source

Engineered Bacteria‐Vesicle Delivered Lactate Reprogramming Boosts Tumor Radiosensitivity

Advanced Science, EarlyView.
We engineered a bacterial‐vesicular dual‐delivery platform that targets LOx to colorectal tumors, enabling lactate clearance, immune microenvironment remodeling, and microbiota modulation. This microbe–metabolism synergistic strategy effectively sensitizes colorectal cancer to radiotherapy, offering a promising approach to overcome radioresistance ...
Fei Peng, Zhe Lei, Zhehao Zhang, Zhiyue Su, Chonghai Zhang, Huan Yang, Shu Liu, Mengyuan Hu, Yuhong Wang, Lingchuan Guo, Lin Hu, Kai Yang   +11 more
wiley   +1 more source

A luminescence-based point-of-care HIV viral load test for antiretroviral therapy monitoring. [PDF]

Lab Chip
Kim S, Hong HR, Oh JM, Chun J, Chellappaa A, Yoo J, Husain SM, Lee J, Kim J, Thirumalaraju P, Song Y, Kanakasabapathy MK, Gwak J, Hardie JM, Kuritzkes DR, Li JZ, Tsibris AM, Shafiee H.   +17 more
europepmc   +1 more source

Bioluminescence Analysis of Antibacterial Photodynamic Therapy Using Methylene Blue Mediated by Low-Intensity Level Laser Against Cariogenic Biofilms

, 2018
Fernando Luís Esteban Florez, Morgana Regina Mendonça de Oliveira, Osmir Batista de Oliveira, Rochelle Denise Hiers, Sharukh S. Khajotia, Hermes Pretel   +5 more
openalex   +2 more sources

Cholesterol Promotes Lung Adenocarcinoma Brain Metastasis by Stabilizing EGFR Protein to Drive EMT, Metabolic Reprogramming, and Premetastatic Niche Formation

Advanced Science, EarlyView.
Cholesterol is revealed as a multitasking fuel for lung adenocarcinoma brain metastasis: it locks EGFR at the membrane to sustain AKT/NF‐κB–driven glycolysis and EMT, loosens the blood–brain barrier by promoting Claudin‐5 loss, and rewires microglia through IL‐4R lipid‐raft–JAK1/STAT6 signaling.
Ying Chen, Xiaoteng Cui, Xinyi Shi, Xu Yang, Yujing Cao, Haolin LI, Qi Zhan, Qixue Wang, Ang Li, Qihong Cheng, Yunfei Wang, Junhu Zhou, MingJie Wang, Chunsheng Kang, Xiaomin Liu   +14 more
wiley   +1 more source

Applications of bioluminescence-mediated photodynamic therapy (BL-PDT) for the treatment of deep-seated tumours. [PDF]

Discov Oncol
Mohlongo M, George BP, Abrahamse H.
europepmc   +1 more source