Results 41 to 50 of about 62,595 (258)

Engineering a 660 nm-Responsive Optogenetic Inducer of Pyroptosis for Precision Cancer Therapy. [PDF]

Adv Sci (Weinh)
This study reports a bioorthogonal pyroptosis inducer, PyroRACS. By using a red‐light‐responsive Cre‐On genetic switch to control the expression of highly cytotoxic GSDMDNT, PyroRACS enables the artificial induction of pyroptosis with precise spatiotemporal control.
Zhang M, Li Z, Ma Y, Sun Y, Chen W, Huang W.   +5 more
europepmc   +2 more sources

Taming the Production of Bioluminescent Wood Using the White Rot Fungus Desarmillaria Tabescens

Advanced Science
Although bioluminescence is documented both anecdotally and experimentally, the parameters involved in the production of fungal bioluminescence during wood colonization have not been identified to date.
Francis W. M. R. Schwarze, Tiago Carvalho, Giacomo Reina, Luiz Garcia Greca, Urs Buenter, Zennat Gholam, Leonard Krupnik, Antonia Neels, Luciano Boesel, Hugh Morris, Markus Heeb, Anja Huch, Gustav Nyström, Giorgia Giovannini   +13 more
doaj   +1 more source

Increased Autonomous Bioluminescence Emission from Mammalian Cells by Enhanced Cofactor Synthesis

Chemosensors
The bacterial bioluminescence system has been successfully implemented in mammalian cell lines, enabling the substrate-free luminescence imaging of living cells. One of the major limitations of the system is its comparatively low brightness.
Theresa Brinker, Carola Gregor
doaj   +1 more source

Bioluminescence Monitoring of Neuronal Activity in Freely Moving Zebrafish Larvae

Bio-Protocol, 2017
The proof of concept for bioluminescence monitoring of neural activity in zebrafish with the genetically encoded calcium indicator GFP-aequorin has been previously described (Naumann et al., 2010) but challenges remain.
Steven Knafo, Andrew Prendergast, Olivier Thouvenin, Sophie Figueiredo, Claire Wyart   +4 more
doaj   +1 more source

Evaluation of the bioluminescence activity, biokinetics, and the effects of binary mixtures of inducers on the Pm-lux recombinant strain

Frontiers in Environmental Science, 2022
The bioluminescence activity and biokinetics of a recombinant Pseudomonas putida mt-2 were investigated in the presence of various inducers: three chlorotoluenes (CTs) and two nitrotoluenes (NTs).
In Chul Kong, Sohyeon Lee, Kyoochul Ha, Kyung-Seok Ko   +3 more
doaj   +1 more source

Coixenolide Enhances Antitumor Immunity of Cytotoxic CD8+ T Cells by Inhibiting S100A8/A9‐CD36 Axis in Obesity‐Associated Pancreatic Adenocarcinoma

Advanced Science, EarlyView.
Pancreatic adenocarcinoma (PAAD) remains highly lethal with limited treatment options. This study demonstrates that coixenolide, a bioactive compound from Coix lacryma‐jobi L. and a key component of the clinically approved Kanglaite injection, exhibits enhanced antitumor efficacy in high‐fat diet (HFD)‐induced obese mice bearing PAAD tumors compared to
Kaidi Chen, Rong Chen, Wei Li, Bin Song, Ruiying Zhang, Lewei Dai, Yuwei Qi, Ruqian Chen, Yifan Xu, Hangbin Li, Jingyi Huang, Fangping Wu, Jianan Peng, Xinyu Wang, Yang Xiong, Chaofeng Mu, Guilin Cheng, Zhaoshen Li, Shanming Ruan, Lei Huang, Mancang Gu   +20 more
wiley   +1 more source

A review of mechanically stimulated bioluminescence of marine plankton and its applications

Frontiers in Marine Science
Bioluminescence is ubiquitous in marine ecosystems and found in uni- and multicellular organisms. Bioluminescent displays can be used to deter predators, attract mates, and lure and hunt prey.
Francis Letendre, Michael Twardowski, Abigail Blackburn, Carina Poulin, Michael I. Latz   +4 more
doaj   +1 more source

Synthetic Toll‐Like Receptors for Control of Innate Immunity With Far‐Red Light

Advanced Science, EarlyView.
Synthetic Toll‐like receptors (TLRs) are engineered by replacing their natural sensing regions with a far‐red‐light‐responsive module from a bacterial phytochrome. These synthetic receptors enable light‐controlled regulation of immune signaling in mammalian cells.
Anna V. Leopold, Vladislav V. Verkhusha
wiley   +1 more source

In Vivo Imaging of Immune Rejection of MIN6 Cells Transplanted in C3H Mice

Cells
Recently, we successfully utilized noninvasive magnetic resonance and bioluminescence imaging to track MIN6 cells subcutaneously transplanted in immunocompromised nude mice for up to 64 days.
Jyuhn-Huarng Juang, Chen-Ling Chen, Chen-Wei Kao, Shu-Ting Wu, Chia-Rui Shen   +4 more
doaj   +1 more source

Pre‐Regenerative Endothelial Cells Empowered by Antler Blood Exosomes Orchestrate Peripheral Nerve Repair

Advanced Science, EarlyView.
The pre‐regenerative vascular niche (PVN) is essential for nerve repair, yet its endothelial blueprint remains unclear. We identified angiogenic ECs (AECs) as the dominant pre‐regenerative subset and found that antler blood–derived exosomes (AB‐EXO) promote repair via IMP3.
Jinsheng Huang, Qiang Chen, Aihua Jin, Xiaoqi Yang, Hui Zhou, Weiquan Gong, Jin Cheng, Jun Dai, Minjin Wang, Meihua Piao, Yuanyi Wang, Nan Zhou   +11 more
wiley   +1 more source