Results 61 to 70 of about 62,595 (258)

CALB2 is a Mechanoresistance Gene in Metastatic Prostate Cancer

Advanced Science, EarlyView.
Prostate cancer cell lines of differing origins were cultured over many passages while being subjected to semi‐lethal levels of fluid shear stress, representing the harsh mechanical environment these cells are subjected to in the circulation during the process of distant metastasis.
Abigail R. Fabiano, Allen C. Luo, Paul Taufalele, Jenna A. Dombroski, Ehsan Aalaei, Schyler J. Rowland, Melissa S. Cantú, Alexandria T. Carter, Samantha V. Knoblauch, Cynthia A. Reinhart‐King, Michael R. King   +10 more
wiley   +1 more source

Bioluminescence:

, 2022
Bioluminescence, the phosphorous cold light that emanates from living organisms, is a central figure of Gail Jones’s second novel Sixty Lights (2004). The novel announces itself as a venture in light writing by its title, the names of its characters (Lucy and Isaac Newton), its sixty-section album structure, narrative events and, ironically, its ...
openaire   +2 more sources

Deletion of luxI increases luminescence of Vibrio fischeri

mBio
Bioluminescence in Vibrio fischeri is regulated by a quorum-dependent signaling system composed of LuxI and LuxR. LuxI generates N-3-oxohexanoyl homoserine lactone (3OC6-HSL), which triggers LuxR to activate transcription of the luxICDABEG operon ...
Kathryn A. Bellissimo, Alecia N. Septer, Cheryl A. Whistler, Coralis Rodríguez, Eric V. Stabb   +4 more
doaj   +1 more source

Validating Bioluminescence Imaging as a High-Throughput, Quantitative Modality for Assessing Tumor Burden

Molecular Imaging, 2004
Bioluminescence imaging (BLI) is a highly sensitive tool for visualizing tumors, neoplastic development, metastatic spread, and response to therapy. Although BLI has engendered much excitement due to its apparent simplicity and ease of implementation ...
Zain Paroo, Robert A. Bollinger, Dwaine A. Braasch, Edmond Richer, David R. Corey, Peter P. Antich, Ralph P. Mason   +6 more
doaj   +1 more source

Optimized Lipid Nanoparticles with Tail‐Modified Ionizable Lipids for Safer mRNA Delivery

Advanced Science, EarlyView.
Systematic engineering of hydrophobic tail architecture in vitamin B5‐derived ionizable lipids establishes a comprehensive structure–activity relationship framework for mRNA delivery. Combined lipidtail and formulation optimization identifies TM1‐OPT3‐C, a lipid nanoparticle platform that improves efficacy–safety balance through efficient mRNA delivery,
Seo‐Hyeon Bae, Jisun Lee, Jae‐Hun Ahn, Hosam Choi, Huijeong Choi, Jungmin Kim, Minho Kang, Ho Rim Oh, So Hyun Park, Eun Young Oh, Sanghyuk Jeon, Yeeun Lee, Yu‐Sun Lee, Na‐Young Lee, Hee‐Jin Bae, Jina Kwak, Jooil Kim, Nakyung Lee, Beomsun Kang, Ji‐Hye Kim, Eunsaem Song, Daesub Song, Hyunho Yoon, Sang‐Myeong Lee, Hyewon Youn, Kiyoun Lee, Byeong‐Cheol Kang, Jae‐Hwan Nam   +27 more
wiley   +1 more source

Histone H3K18 Lactylation Promotes the Malignant Progression of Wilms Tumor via a PSRC1/AKT/HIF‐1α Positive Feedback Loop

Advanced Science, EarlyView.
In nephroblastoma, aberrant glycolysis drives lactate accumulation, which elevates histone H3K18 lactylation via p300. Lactylation of the PSRC1 promoter activates its transcription. PSRC1 competitively binds AKT, relieving PTEN‐mediated inhibition and triggering AKT/mTOR/HIF‐1α signaling.
Yanping Wang, Hongjie Gao, Bifei Zhang, Xuetian Li, Ding Li, Aihua Cao, Fengyin Sun   +6 more
wiley   +1 more source

LRG1 Drives Pathological Angiogenesis by Disrupting Neutrophil Mitochondrial Homeostasis in Bladder Cancer

Advanced Science, EarlyView.
In bladder cancer, LRG1 binds to ANXA2 to trigger mitochondrial ROS‐dependent NETosis. This pathogenic cascade actively uncouples endothelial‐mural cell interactions, driving profound vascular destabilization. Consequently, targeting the LRG1‐ANXA2 axis attenuates the neutrophil burden and induces structural vascular normalization, offering a powerful ...
Dongshan Chen, Cong Zhang, Song Xue, Yuan Zeng, Haochen Cui, Chenfei Wang, Jiayi Feng, Lei Yan, Yuanwei Zang   +8 more
wiley   +1 more source

Phagocytosis by macrophages decreases the radiance of bioluminescent Staphylococcus aureus

BMC Microbiology
Background In vivo evaluations of the antimicrobial efficacy of biomaterials often use bioluminescent imaging modalities based on bioluminescent bacteria to allow follow-up in single animals.
Elles C. Boonstra, Liliana Agresti, Henny C. van der Mei, Paul C. Jutte, Jelmer Sjollema   +4 more
doaj   +1 more source

BIOLUMINESCENT DINOFLAGELLATES ,

The Biological Bulletin, 1963
(Uploaded by Plazi from the Biodiversity Heritage Library) No abstract provided.
openaire   +3 more sources

A Glucose Metabolism‐Modulatory Nanobiohybrid Vaccine Platform Promotes Anti‐Tumor Immunity by Orchestrating Autophagy‐Dependent Cross‐Presentation and H2S‐Enhanced NLRP3 Inflammasome Signaling

Advanced Science, EarlyView.
A nanobiohybrid vaccine was designed by constructing a hydrogen‐bonded organic framework coencapsulated with glucose oxidase (GOx) and tumor antigens. This nanobiohybrid vaccine executed a GOx‐catalyzed enzyme reaction that disrupted glucose metabolism and induced redox imbalance in dendritic cells, leading to autophagy‐dependent antigen cross ...
Weidong Wang, Yimin Gong, Jianing Li, Tianze Wu, Mingli Deng, Yannan Yang   +5 more
wiley   +1 more source