Increased Autonomous Bioluminescence Emission from Mammalian Cells by Enhanced Cofactor Synthesis
ChemosensorsThe bacterial bioluminescence system has been successfully implemented in mammalian cell lines, enabling the substrate-free luminescence imaging of living cells. One of the major limitations of the system is its comparatively low brightness.
Theresa Brinker, Carola Gregor
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The small molecule ephrin receptor inhibitor, GLPG1790, Reduces renewal capabilities of cancer stem cells, showing anti-tumour efficacy on preclinical glioblastoma models [PDF]
, 2019 Therapies against glioblastoma (GBM) show a high percentage of failure associated with the survival of glioma stem cells (GSCs) that repopulate treated tumours.
Beirinckx, Filip +15 more
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From Lab to Landscape: Environmental Biohybrid Robotics for Ecological Futures
Advanced Robotics Research, EarlyView.This Perspective explores environmental biohybrid robotics, integrating living tissues, microorganisms, and insects for operation in real‐world ecosystems. It traces the leap from laboratory experiments to forests, wetlands, and urban environments and discusses key challenges, development pathways, and opportunities for ecological monitoring and ...
Miriam Filippi
wiley +1 more source
A review of mechanically stimulated bioluminescence of marine plankton and its applications
Frontiers in Marine ScienceBioluminescence is ubiquitous in marine ecosystems and found in uni- and multicellular organisms. Bioluminescent displays can be used to deter predators, attract mates, and lure and hunt prey.
Francis Letendre +4 more
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PD‐1 Inhibits CD4+ TRM‐Mediated cDC1 Mobilization via Suppressing JAML in Human NSCLC
Advanced Science, EarlyView.CD4+ tissue‐resident memory T cells (TRMs) in non‐small cell lung cancer recruit conventional type 1 dendritic cells via XCL1‐XCR1 signaling, orchestrating antitumor immunity. The costimulatory molecule JAML is essential for this process. PD‐1 blockade restores JAML expression and cDC1 mobilization, while JAML agonists synergize with anti‐PD‐1 therapy,
Zheyu Shao +16 more
wiley +1 more source
In Vivo Imaging of Immune Rejection of MIN6 Cells Transplanted in C3H Mice
CellsRecently, we successfully utilized noninvasive magnetic resonance and bioluminescence imaging to track MIN6 cells subcutaneously transplanted in immunocompromised nude mice for up to 64 days.
Jyuhn-Huarng Juang +4 more
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A PERIOD3 variant causes a circadian phenotype and is associated with a seasonal mood trait. [PDF]
, 2016 In humans, the connection between sleep and mood has long been recognized, although direct molecular evidence is lacking. We identified two rare variants in the circadian clock gene PERIOD3 (PER3-P415A/H417R) in humans with familial advanced sleep phase ...
Fu, Ying-Hui +15 more
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Advanced Science, EarlyView.IL‐15‐engineered stem cell–NK cell complexes, assembled via bioorthogonal chemistry, enable effective lung cancer immunotherapy. Abstract Natural killer (NK) cells represent a powerful immunotherapeutic strategy due to their intrinsic cytotoxicity and ability to target tumor cells independently of antigen presentation.
Qian Zhang +15 more
wiley +1 more source
A method for capturing images of Collembola bioluminescence using a smartphone camera
Soil OrganismsAlthough bioluminescence in Collembola has been known since 1851, photographic evidence remains sparse. Photographs serve as essential evidence to confirm bioluminescence and facilitate further investigations into this phenomenon.
Atsuko Ohira, Taizo Nakamori
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