Results 111 to 120 of about 44,745 (290)

Luciferase expression and bioluminescence does not affect tumor cell growth in vitro or in vivo

Molecular Cancer, 2010
Live animal imaging is becoming an increasingly common technique for accurate and quantitative assessment of tumor burden over time. Bioluminescence imaging systems rely on a bioluminescent signal from tumor cells, typically generated from expression of ...
Rasko John EJ, Ng Cynthia, Bailey Charles G, Tiffen Jessamy C, Holst Jeff   +4 more
doaj   +1 more source

Bioluminescence imaging of estrogen receptor activity during breast cancer progression [PDF]

, 2016
Estrogen receptors (ER) are known to play an important regulatory role in mammary gland development as well as in its neoplastic transformation. Although several studies highlighted the contribution of ER signaling in the breast transformation, little is
I. Manni, C. Vantaggiato, A. Maggi, G. Piaggio, P. Ciana, G. Dell'Omo, B. Ramachandran, E. Radaelli, E. Scanziani   +8 more
core  

Tyrosinase Driven‐Intracellular Polymerization of a Porphyrin Derivative Induced Immunogenic Death of Melanoma Cells and Strengthened Photodynamic Therapy

Advanced Science, EarlyView.
This study uses tyrosinase, which is highly expressed in melanoma, to drive porphyrins to polymerize and self‐assemble within tumor cells to form retented microstructures. This process induces immunogenic death and activates immune responses (M1 macrophages, dendritic cells, CD8+T cells), turning “cold” tumors into “hot” tumors.
Mian Tang, Junteng Qiu, Yunfeng Lu, Yahui Song, Xinyu Zhou, Tianshun Duan, Xuanqi Peng, Caixia Yin, Cheng Gao, Ruibing Wang   +9 more
wiley   +1 more source

Application of luminescence-producing Mycobacterium tuberculosis strains for evaluating anti-tuberculosis drug and vaccine efficacy in vitro and in vivo

BMC Infectious Diseases
Background Tuberculosis (TB), caused by Mycobacterium tuberculosis (M.tb), remains a major public health problem worldwide. The development of effective drugs and vaccines remains crucial but the prolonged culture period of M.tb hampers this process ...
Soo-Min Kim, Eunkyung Shin, Jin-Seung Yun, Jaeseon Jeon, Sohee Park, Yong Woo Jung, Dokeun Kim, Hye-Sook Jeong   +7 more
doaj   +1 more source

Monitoring disease progression and therapeutic response in a disseminated tumor model for non-hodgkin lymphoma by bioluminescence imaging

, 2022
S.400-411Xenograft tumor models are widely studied in cancer research. Our aim was to establish and apply a model for aggressive CD20- positive B-cell non-Hodgkin lymphomas, enabling us to monitor tumor growth and shrinkage in a noninvasive manner.
Kamprad, Manja, Müller, Kristin, Scholz, Markus R., Köberle, Margarethe, Horn, Friedemann   +4 more
core   +1 more source

Scalable Engineering of Bio‐Manufactured Extracellular Vesicles for Selective Delivery in Ovarian Cancer Patient‐Derived Models

Advanced Science, EarlyView.
Engineered extracellular vesicles displaying Ephrin‐B2 selectively target Ephrin‐B4–expressing ovarian cancer cells, enabling precise delivery in patient‐derived models. This scalable bio‐manufacturing platform reveals a versatile strategy to exploit Ephrin signaling for highly specific therapeutic payload delivery and motivates exploration of tailored
Nihar Godbole, Andrew Lai, Alexander Quinn, Marianne Gillard, Dominic Guanzon, Katherin Scholz‐Romero, Alexis Salas‐Burgos, Bastián Lillo Dapremont, Rohan Lourie, Naven Chetty, Richard Lobb, Kate Beecher, Amy E. McCart Reed, Kaltin Ferguson, Biao Sun, Yaowu He, John D. Hooper, Carlos Salomon   +17 more
wiley   +1 more source

Bioluminescence tomography improves quantitative accuracy for pre-clinical imaging [PDF]

, 2013
A study is presented that demonstrates that bioluminescence tomography can reconstruct accurate 3D images of internal light sources placed at a range of depths within a physical phantom and that it provides more reliable quantitative data than standard ...
Guggenheim, J.A.; id_orcid, Dehghani, H.; id_orcid, Frampton, J., Basevi, H.R.A., Styles, I.B.; id_orcid   +4 more
core   +1 more source

Allosteric DNAzyme‐Enabled Sensitive and Multiplex Detection of Biomarkers for Rapid Diagnosis of Urinary Tract Infections

Advanced Science, EarlyView.
A catalytic allosteric DNAzyme assay (SMART) is developed by engineering DNAzyme into a unimolecular biosensor, enabling highly sensitive and multiplex detection of small molecules and nucleic acids. SMART enables extraction‐free, one‐pot, one‐step, isothermal, and cost‐effective detection of biological markers, achieving >95% accuracy for rapid ...
Yanzhe Shen, Chenzhi Shi, Xiaowei Ma, Pengfei Hou, Haomin Zhang, Juanxiu Qin, Li Pan, Guilin Li, Lifei Gao, Qian Ma, Donglei Yang, Min Li, Pengfei Wang   +12 more
wiley   +1 more source

Bioluminescence imaging of lung tumors.

, 2013
Growth of orthotopic lung tumors was measured at defined time-points using bioluminescence imaging. Intrabronchially induced tumors (A) appeared initially in the jugular region and disseminated to the deeper lungs at later time points, whereas ...
Patricia Ohana (350176), Günther Hasenpusch (350166), Michal Gilon (350173), Corinna Pfeifer (350167), Avraham Hochberg (350179), Dietrich Reinhardt (350171), Carsten Rudolph (333357), Manish Kumar Aneja (350168), Kai Wagner (350170)   +8 more
core   +1 more source

Cancer‐Associated Fibroblast‐Derived Sphingosine‐1‐Phosphate Activates a MALL–SDC4 Axis to Facilitate Perineural Invasion in Pancreatic Cancer

Advanced Science, EarlyView.
CAF‐derived S1P activates the S1PR3‐JNK‐Jun signaling pathway, thereby transcriptionally upregulating MALL expression in cancer cells. MALL increases the cell‐surface abundance of SDC4 by promoting its recycling and restricting its lysosomal degradation, which in turn enhances RhoA‐p‐MLC2‐dependent amoeboid invasion and SDC4‐PTN axis‐mediated cancer ...
Wang Peng, Mengdie Cao, Hai Huang, Shuya Bai, Luyao Liu, Jingwen Liang, Haochen Cui, Qiaodan Zhou, Shiru Chen, Jiamei Jiang, Luoxia Liu, Zhou Luan, Wei Chen, Si Xiong, Ronghua Wang, Bin Cheng, Yuchong Zhao   +16 more
wiley   +1 more source