Results 151 to 160 of about 44,745 (290)
This protocol describes a bioluminescence stepwise imaging protocol in mice with AAV-luciferaseexpression in the vagal afferents using the Ivis Lumina series III imaging system.
Santiago Unda, Michael G. Kaplitt
openaire +1 more source
Expedient Synthesis of Electronically Modified Luciferins for Bioluminescence Imaging
, 2016 Bioluminescence imaging with luciferase enzymes requires access to light-emitting, small-molecule luciferins. Here, we describe a rapid method to synthesize d-luciferin, the substrate for firefly luciferase (Fluc), along with a novel set of ...
Jennifer A. Prescher (1616638) +3 more
core +1 more source
Advanced Science, EarlyView.This study presents a surfaceome‐reprogramming strategy for mutation‐independent lung cancer therapy by repurposing dexamethasone to prime mesenchymal stem cell‐derived nanovesicles. The engineered vesicles leverage multi‐valent interactions mediated by upregulated adhesion proteins, EPHA2, and NOTCH3.
Geunhye Kim +8 more
wiley +1 more source
, 2009 *Purpose:* To investigate the MR imaging of _Bifidobacterium longum_ and _Clostridium novyi-NT_ labeling with superparamagnetic iron oxide (SPIO) nanoparticles. *Materials and methods:* Tubes containing _B. longum_-SPIO, Free-SPIO, _B.
Xuebin Zhang +4 more
core
Rapid, multiplexed bioluminescence imaging at all length scales
, 2022 Bioluminescence imaging (BLI) is a powerful tool for in vivo detection of biological events or processes. BLI relies on light production from a chemical reaction, the luciferase-catalyzed oxidation of a small molecule substrate (luciferin). No excitation
Brennan, Caroline Kathleen
core
Designer Dynamic DNA Nanoaggregate in Living Cell for Mitochondrial Energy Restriction
Advanced Science, EarlyView.This study presents the Tech‐tetrahedron, a designer dynamic DNA nanoaggregate engineered for precise mitochondrial energy restriction. Its trinity‐functionalized design integrates navigable unit, telomerase‐activated latch, and self‐assembly module.
Ruijia Deng +12 more
wiley +1 more source
Bioluminescence imaging of mice following secondary transplantation.
, 2013 Whole bone marrow cells from NSG mice transplanted with mock-infected, or DM scAAV6-B19p6-Gluc vector-infected primary human CD34+ cells were harvested 12-weeks post-primary transplantation, and transplanted into secondary recipient mice.
Changquan Ling (389354) +11 more
core +1 more source
Advanced Science, EarlyView.Cancer vaccines face limitations in pancreatic cancer due to insufficient tumor antigens. This ionic liquid ILvax via local tumor delivery triggers robust cDC1‐dependent systemic anti‐tumor immunity. It boosts endogenous CD8+ T cells and optimizes adoptive TCR‐T function, providing a promising synergistic therapeutic strategy.
Junming Huang +11 more
wiley +1 more source
Advanced Science, EarlyView.Inhibition of KDELR2 in a small fraction of tumor cells generates sustainable immunogenic cell death conditions within the tumor microenvironment. These conditions promote the regression of tumors in a T cell independent manner. During regression, macrophages prime T cells that subsequently provide systemic protection against recurrence. The potency of
Shakti P Pattanayak +6 more
wiley +1 more source
The NADPH oxidase NOX4 regulates redox and metabolic homeostasis preventing HCC progression
Hepatology, EarlyView., 2022 Loss of NOX4 in HCC tumor cells induces metabolic reprogramming in a Nrf2/MYC‐dependent manner to promote HCC progression. Abstract Background and Aims The NADPH oxidase NOX4 plays a tumor‐suppressor function in HCC. Silencing NOX4 confers higher proliferative and migratory capacity to HCC cells and increases their in vivo tumorigenic potential in ...
Irene Peñuelas‐Haro +14 more
wiley +1 more source