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Bioluminescence imaging: looking beyond the light
Trends in Molecular Medicine, 2012Bioluminescence imaging (BLI) enables in vivo imaging of molecular and cellular processes. It has gained in popularity over the past decade because of its easy translation from in vitro to in vivo experiments, its sensitivity, and its ease of use.
Keyaerts, Marleen +2 more
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Bioluminescence technology for imaging cell proliferation
Current Opinion in Biotechnology, 2005As continuous cell proliferation caused by genetic alterations leads to cancer, monitoring abnormal cell proliferation in sporadic tumor models is important in the context of tumor generation, development and response to therapy. Bioluminescence imaging technology, which visualizes the conversion of chemical energy into visible light by luciferase ...
Hiroyuki, Momota, Eric C, Holland
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Validation of Bioluminescent Imaging Techniques
2009Bioluminescence imaging (BLI) is frequently cited for its ease of quantification. This fundamental strength of BLI has led to applications in cancer research, cell transplantation, and monitoring of infectious disease in which bioluminescence intensity is correlated with other metrics. However, bioluminescence measurements can be influenced by a number
John, Virostko, E Duco, Jansen
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In Vivo Imaging of Bioluminescent Leptospires
2020The study of pathological processes is often limited to in vitro or ex vivo assays, while understanding pathogenesis of an infectious disease requires in vivo analysis. The use of pathogens, genetically modified to express with luminescent enzymes, combined to charge-coupled device (CCD) cameras, constitutes a major technological advance for assessing ...
Vernel-Pauillac, Frédérique +1 more
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Using bioluminescence imaging in glioma research
Journal of Clinical Neuroscience, 2015Glioblastoma multiforme (GBM) is the most common malignant brain tumour and has the worst prognosis. Over the last decade, the use of bioluminescence imaging technology has rapidly become widespread to further understand the mechanisms that drive GBM development and progression.
Rodney B, Luwor +2 more
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In Vivo Bacterial Imaging Using Bioluminescence
2018Bacterial luminescence allows for noninvasive continuous monitoring of promoter activity in a wide range of model systems. This chapter details various examples of use of the lux reporter system to measure promoter activity in bacteria using the vector pUC18T-mini-Tn7T-lux-Tp.
Mariette, Barbier +2 more
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Optical Bioluminescence Protocol for Imaging Mice
2018The presence, growth, or decline of transfected cell populations expressing the enzyme Luciferase can be followed in live mice using bioluminescence optical imaging techniques. This protocol describes how to verify the imaging equipment, options for injecting the substrate Luciferin into mice, image acquisition considerations, and commonly used data ...
David, Stout, John, David
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Noninvasive Bioluminescent Imaging of Infections
2009Traditional studies of viral and bacterial infection and pathogenesis have generally relied on animal models that require the sacrifice of infected animals to determine viral or bacterial distributions and titers. The recent application of the in vivo bioluminescence imaging (BLI) to monitor the replication and tropism of pathogens expressing the ...
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Bioluminescent Capsules for Live-Cell Imaging
Bioconjugate Chemistry, 2012A bioluminescent capsule was designed for illuminating cell signaling and protein localization. The capsule consists of four components, namely, a secretion peptide (SP), a luciferase body, a cargo protein (or peptide), and a membrane-localization signal (MLS).
Sung Bae, Kim +2 more
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Image-guided simulation for bioluminescence tomographic imaging
SPIE Proceedings, 2005Noninvasive imaging of the reporter gene expression based on bioluminescence is playing an important role in the areas of cancer biology, cell biology, and gene therapy. The central problem for the bioluminescence tomography (BLT) we are developing is to reconstruct the underlying bioluminescent source distribution in a small animal using a modality ...
Durairaj Kumar +9 more
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