Results 51 to 60 of about 44,745 (290)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Increased Autonomous Bioluminescence Emission from Mammalian Cells by Enhanced Cofactor Synthesis

Chemosensors
The bacterial bioluminescence system has been successfully implemented in mammalian cell lines, enabling the substrate-free luminescence imaging of living cells. One of the major limitations of the system is its comparatively low brightness.
Theresa Brinker, Carola Gregor
doaj   +1 more source

Combined in Vivo Bioluminescence and Fluorescence Imaging for Cancer Gene Therapy

Molecular Imaging, 2004
Nasopharyngeal carcinoma is intimately associated with the Epstein-Barr virus (EBV), which we have exploited therapeutically by constructing an EBV-specific synthetic enhancer sequence, within an adenoviral vector, denoted as adv.oriP. The achievement of
J. D. Mocanu, E. H. Moriyama, M. C. Chia, J.-H. Li, K. W. Yip, D. P. Huang, C. Bastianutto, B. C. Wilson, F.-F. Liu   +8 more
doaj   +1 more source

Practical reconstruction method for bioluminescence tomography [PDF]

, 2005
Bioluminescence tomography (BLT) is used to localize and quantify bioluminescent sources in a small living animal. By advancing bioluminescent imaging to a tomographic framework, it helps to diagnose diseases, monitor therapies and facilitate drug ...
Kumar, D, Liu, Y, Cong, A, Wang, Ge, McCray, PB, Kumar, Durairaj, Zabner, Joseph, McLennan, Geoffrey, Zabner, J, Cong, WX, Jiang, Ming, Wang, G, McLennan, G, Cong, Alexander, Hoffman, EA, Hoffman, Eric A., Jiang, M, Wang, LV, Liu, Yi, Cong, Wenxiang, Wang, Lihong V., McCray, Paul B.   +21 more
core   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

In Vivo Cell Tracking with Bioluminescence Imaging [PDF]

Nuclear Medicine and Molecular Imaging, 2014
Molecular imaging is a fast growing biomedical research that allows the visual representation, characterization and quantification of biological processes at the cellular and subcellular levels within intact living organisms. In vivo tracking of cells is an indispensable technology for development and optimization of cell therapy for replacement or ...
Jung Eun, Kim, Senthilkumar, Kalimuthu, Byeong-Cheol, Ahn   +2 more
openaire   +2 more sources

Fusion expression of bifunctional enzyme complex for luciferin-recycling to enhance the luminescence imaging

, 2018
Firefly luciferase (Fluc) has been widely used as a bioluminescent monitor. The ATP linear correlation and exogenous luciferin requirement make it useful in most of current imaging systems.
Tang, Xu, Chang'an Xu, Hill, Phil, Baishan Fang, Sun, Xiaohui, Xu, Chang'an, Wang, Qinghua, Chen, Pinghong, Fang, Baishan, Xiaohui Sun, Xu Tang, Phil Hill, Qinghua Wang, Pinghong Chen   +13 more
core   +1 more source

Bioluminescence Imaging with Functional Amyloid Reservoirs in Alzheimer’s Disease Models

, 2023
Bioluminescence imaging has changed the daily practice of preclinical research on cancer and other diseases over the last few decades; however, it has rarely been applied in preclinical research on Alzheimer’s disease (AD).
Weihua Ding (3140856), Shiqian Shen (11211465), Shiqian Shen, Jun Yang, Rudolph E. Tanzi, Shi Kuang, Biyue Zhu, Chongzhao Ran (222663), Wei Yin (64393), Fan Yang, Sherri Zhen (16992588), Peng Wang, Weihua Ding, Liuyue Yang, Jing Yang, Jun Yang (2084), Can Zhang (56016), Rudolph E. Tanzi (178268), Peng Wang (34436), Shi Kuang (11097795), Liuyue Yang (13211625), Biyue Zhu (11097798), Can Zhang, Wei Yin, Jing Yang (13969), Fan Yang (1413), Sherri Zhen, Chongzhao Ran   +27 more
core   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Molecular Imaging Reveals Skeletal Engraftment Sites of Transplanted Bone Marrow Cells

Cell Transplantation, 2006
Molecular imaging holds great promise for the in vivo study of cell therapy. Our hypothesis was that multimodality molecular imaging can identify the initial skeletal engraftment sites post-bone marrow cell transplantation.
Philipp Mayer-Kuckuk, Mikhail Doubrovin, Luc Bidaut, Tulin Budak-Alpdogan, Shangde Cai, Vanessa Hubbard, Onder Alpdogan, Marcel Van Den Brink, Joseph R. Bertino, Ronald G. Blasberg, Debabrata Banerjee, Juri Gelovani   +11 more
doaj   +1 more source