Results 81 to 90 of about 64,944 (323)

A Semisynthetic Bioluminescence Sensor for Ratiometric Imaging of Metal Ions In Vivo Using DNAzymes Conjugated to An Engineered Nano‐Luciferase [PDF]

, 2023
Mengyi Xiong, Yuting Wu, Gezhi Kong, Whitney Lewis, Zhenglin Yang, Hanxiao Zhang, Xu Li, Ying Liu, Qin Liu, Xuhua Zhao, Xiaobing Zhang, Yi Lu   +11 more
openalex   +1 more source

Multivalent Protein Nanorings for Broad and Potent SARS‐CoV‐2 Neutralization

Advanced Healthcare Materials, EarlyView.
A protein‐only, modular multivalent nanoscaffold displaying 20 anchor points, decorated with two different binders (10 of each), targeting the SARS‐CoV‐2 receptor‐binding domain is presented. The construct self‐assembles into stable, biocompatible, homogeneous nanoparticles, exhibit synergistic binding with fM IC50 values. It also detects spike at 9 ng 
Molood Behbahanipour, Carla Goldin, Cecilia Arahi Prato, Ana Luz Paletta, Oriol Bárcenas, Susanna Navarro, Jordi Pujols, Daniel H. Murgida, María Virginia Tribulatti, Sebastián Esperante, Damian Alvarez‐Paggi, Salvador Ventura   +11 more
wiley   +1 more source

Enhancement of radiosensitivity by the novel anticancer quinolone derivative vosaroxin in preclinical glioblastoma models [PDF]

, 2017
Purpose: Glioblastoma multiforme (GBM) is the most aggressive brain tumor. The activity of vosaroxin, a first-in-class anticancer quinolone derivative that intercalates DNA and inhibits topoisomerase II, was investigated in GBM preclinical models as a ...
Colapietro, Alessandro, Di Cesare, Ernesto, Festuccia, Claudio, Fox, Judith A., Gravina, Giovanni Luca, Mancini, Andrea, Marampon, Francesco, Mattei, Claudia, Rossi, Giulia, Ventura, Luca, Vetuschi, Antonella, Vitale, Flora   +11 more
core   +1 more source

Inhibition of USP7 activity selectively eliminates senescent cells in part via restoration of p53 activity. [PDF]

, 2020
The accumulation of senescent cells (SnCs) is a causal factor of various age-related diseases as well as some of the side effects of chemotherapy. Pharmacological elimination of SnCs (senolysis) has the potential to be developed into novel therapeutic ...
Budamagunta, Vivekananda, Campisi, Judith, He, Yonghan, Li, Wen, Lv, Dongwen, Ortiz, Yuma T, Zhang, Xin, Zhang, Xuan, Zheng, Guangrong, Zhou, Daohong   +9 more
core   +1 more source

Longitudinal Follow-Up of Urinary Tract Infections and Their Treatment in Mice using Bioluminescence Imaging [PDF]

, 2021
Noémie Luyts, Greetje Vande Velde, Matthias Vanneste, Helene De Bruyn, Annelies Janssens, Natalie Verstraeten, Thomas Voets, Wouter Everaerts   +7 more
openalex   +1 more source

Semi-automated Image Processing for Preclinical Bioluminescent Imaging [PDF]

Journal of Applied Bioinformatics & Computational Biology, 2015
Bioluminescent imaging is a valuable noninvasive technique for investigating tumor dynamics and specific biological molecular events in living animals to better understand the effects of human disease in animal models. The purpose of this study was to develop and test a strategy behind automated methods for bioluminescence image processing from the ...
Nikolai V, Slavine, Roderick W, McColl
openaire   +2 more sources

Decellularized Extracellular Matrix (dECM) in Tendon Regeneration: A Comprehensive Review

Advanced Healthcare Materials, EarlyView.
Decellularized Extracellular Matrix (dECM) offers a promising solution by replicating the native tendon microenvironment and promoting regeneration. This review highlights advances in the decellularization methods, as well as their integration with emerging technologies and translational progress in tendon tissue engineering.
Kumaresan Sakthiabirami, Yeonwoo Park, Seong Kyeong Jo, Min Hee Kim, Jae Hwang Song   +4 more
wiley   +1 more source

Current advances in the development of bioluminescent probes toward spatiotemporal trans-scale imaging

Biophysics and Physicobiology
Bioluminescence imaging has recently attracted great attention as a highly sensitive and non-invasive analytical method. However, weak signal and low chemical stability of the luciferin are conventional drawbacks of bioluminescence imaging.
Akihiro Sakama, Mariko Orioka, Yuki Hiruta   +2 more
doaj   +1 more source

Orthotopic hepatocellular carcinoma: molecular imaging-monitored intratumoral hyperthermia-enhanced direct oncolytic virotherapy

International Journal of Hyperthermia, 2019
Objective: To validate the feasibility of molecular imaging-monitored intratumoral radiofrequency hyperthermia (RFH) enhanced direct oncolytic virotherapy for hepatocellular carcinoma (HCC).
Jingjing Song, Feng Zhang, Jiansong Ji, Minjiang Chen, Qiang Li, Qiaoyou Weng, Shannon Gu, Matthew J. Kogut, Xiaoming Yang   +8 more
doaj   +1 more source

Generation of bright autobioluminescent bacteria by chromosomal integration of the improved lux operon ilux2

Scientific Reports, 2022
The bacterial bioluminescence system enables the generation of light by living cells without the requirement of an external luciferin. Due to the relatively low light emission, many applications of bioluminescence imaging would benefit from an increase ...
Carola Gregor
doaj   +1 more source