Results 1 to 10 of about 910,562 (291)

Immune microenvironment characteristics in multiple myeloma progression from transcriptome profiling

Frontiers in Oncology, 2022
Multiple myeloma (MM) is characterized by clonal expansion of malignant plasma cells in the bone marrow (BM). Despite the significant advances in treatment, relapsed and refractory MM has not yet been completely cured due to the immune dysfunction in the
Jin Wang, Yi Hu, Habib Hamidi, Cedric Dos Santos, Jingyu Zhang, Elizabeth Punnoose, Wenjin Li   +6 more
doaj   +1 more source

Cell segmentation for immunofluorescence multiplexed images using two-stage domain adaptation and weakly labeled data for pre-training

Scientific Reports, 2022
Cellular profiling with multiplexed immunofluorescence (MxIF) images can contribute to a more accurate patient stratification for immunotherapy. Accurate cell segmentation of the MxIF images is an essential step.
Wenchao Han, Alison M. Cheung, Martin J. Yaffe, Anne L. Martel   +3 more
doaj   +1 more source

Early and strong antibody responses to SARS-CoV-2 predict disease severity in COVID-19 patients

Journal of Translational Medicine, 2022
Background Antibody response to SARS-CoV-2 is a valuable biomarker for the assessment of the spread of the virus in a population and evaluation of the vaccine candidates. Recent data suggest that antibody levels also may have a prognostic significance in
Jānis Plūme, Artis Galvanovskis, Sindija Šmite, Nadezhda Romanchikova, Pawel Zayakin, Aija Linē   +5 more
doaj   +1 more source

Quantitative single-cell analysis of immunofluorescence protein multiplex images illustrates biomarker spatial heterogeneity within breast cancer subtypes

Breast Cancer Research, 2021
Background The extent of cellular heterogeneity in breast cancer could have potential impact on diagnosis and long-term outcome. However, pathology evaluation is limited to biomarker immunohistochemical staining and morphology of the bulk cancer.
Alison Min-Yan Cheung, Dan Wang, Kela Liu, Tyna Hope, Mayan Murray, Fiona Ginty, Sharon Nofech-Mozes, Anne Louise Martel, Martin Joel Yaffe   +8 more
doaj   +1 more source

Anatomy of an extinction revealed by molecular fossils spanning OAE2

Scientific Reports, 2021
The Cenomanian–Turonian mass extinction (Oceanic Anoxic Event 2-OAE2) was a period of profound ecological change that is recorded in the sedimentary record in many locations around the globe.
R. M. Forkner, J. Dahl, A. Fildani, S. M. Barbanti, I. A. Yurchenko, J. M. Moldowan   +5 more
doaj   +1 more source

Soluble guanylate cyclase signalling mediates etoposide resistance in progressing small cell lung cancer

Nature Communications, 2021
The emergence of acquired resistance to standard platinum-etoposide chemotherapy in small cell lung cancer (SCLC) is a common event. Here, the authors using paired pre-treatment and post-chemotherapy circulating tumour cell patient-derived explant (CDX ...
Maximilian W. Schenk, Sam Humphrey, A. S. Md Mukarram Hossain, Mitchell Revill, Sarah Pearsall, Alice Lallo, Stewart Brown, Samuel Bratt, Melanie Galvin, Tine Descamps, Cong Zhou, Simon P. Pearce, Lynsey Priest, Michelle Greenhalgh, Anshuman Chaturvedi, Alastair Kerr, Fiona Blackhall, Caroline Dive, Kristopher K. Frese   +18 more
doaj   +1 more source

Identification of genetic variants related to metabolic syndrome by next-generation sequencing

Diabetology & Metabolic Syndrome, 2022
Background Metabolic syndrome (MetS) is a cluster of conditions associated with glucose intolerance, hypertension, abdominal obesity, dyslipidemia, and insulin resistance that increase the risk of cardiovascular diseases (CVD) and type 2 diabetes (T2D ...
Sanghoo Lee, Seol-A Kim, Jeonghoon Hong, Yejin Kim, Gayeon Hong, SaeYun Baik, Kyeonghwan Choi, Mi-Kyeong Lee, Kyoung-Ryul Lee   +8 more
doaj   +1 more source

Quality assessment and interference detection in targeted mass spectrometry data using machine learning

Clinical Proteomics, 2018
Advances in the field of targeted proteomics and mass spectrometry have significantly improved assay sensitivity and multiplexing capacity. The high-throughput nature of targeted proteomics experiments has increased the rate of data production, which ...
Shadi Toghi Eshghi, Paul Auger, W. Rodney Mathews   +2 more
doaj   +1 more source

The Optimized Workflow for Sample Preparation in LC-MS/MS-Based Urine Proteomics

Methods and Protocols, 2019
The sample condition is an important factor in urine proteomics with stability and accuracy. However, a general protocol of urine protein preparation in mass spectrometry analysis has not yet been established.
Suguru Saito, Yoshitoshi Hirao, Ali F. Quadery, Bo Xu, Amr Elguoshy, Hidehiko Fujinaka, Shohei Koma, Keiko Yamamoto, Tadashi Yamamoto   +8 more
doaj   +1 more source

High serum granulocyte-colony stimulating factor characterises neutrophilic COPD exacerbations associated with dysbiosis

ERJ Open Research, 2021
Introduction COPD exacerbations are heterogeneous and can be triggered by bacterial, viral, or noninfectious insults. Exacerbations are also heterogeneous in neutrophilic or eosinophilic inflammatory responses.
Arindam Chakrabarti, Jordan S. Mar, David F. Choy, Yi Cao, Nisha Rathore, Xiaoying Yang, Gaik W. Tew, Olga Li, Prescott G. Woodruff, Christopher E. Brightling, Michele Grimbaldeston, Stephanie A. Christenson, Mona Bafadhel, Carrie M. Rosenberger   +13 more
doaj   +1 more source