Results 1 to 10 of about 746,277 (164)

Immune microenvironment characteristics in multiple myeloma progression from transcriptome profiling

Frontiers in Oncology, 2022
Multiple myeloma (MM) is characterized by clonal expansion of malignant plasma cells in the bone marrow (BM). Despite the significant advances in treatment, relapsed and refractory MM has not yet been completely cured due to the immune dysfunction in the
Jin Wang, Yi Hu, Habib Hamidi, Cedric Dos Santos, Jingyu Zhang, Elizabeth Punnoose, Wenjin Li   +6 more
doaj   +1 more source

Cell segmentation for immunofluorescence multiplexed images using two-stage domain adaptation and weakly labeled data for pre-training

Scientific Reports, 2022
Cellular profiling with multiplexed immunofluorescence (MxIF) images can contribute to a more accurate patient stratification for immunotherapy. Accurate cell segmentation of the MxIF images is an essential step.
Wenchao Han, Alison M. Cheung, Martin J. Yaffe, Anne L. Martel   +3 more
doaj   +1 more source

Glucosylsphingosine Is a Highly Sensitive and Specific Biomarker for Primary Diagnostic and Follow-Up Monitoring in Gaucher Disease in a Non-Jewish, Caucasian Cohort of Gaucher Disease Patients [PDF]

, 2013
Gaucher disease (GD) is the most common lysosomal storage disorder (LSD). Based on a deficient β-glucocerebrosidase it leads to an accumulation of glucosylceramide. Standard diagnostic procedures include measurement of enzyme activity, genetic testing as
A Zimran, AC Vedder, Ales Dudesek, Andrea Dardis, Anja Röhle, Anne-Katrin Giese, Ari Zimran, Arndt Rolfs, B Rosengren, C Auray-Blais, CE Hollak, CE Hollak, CE Metz, Daniel Mascher, Deborah Elstein, E Lloyd-Evans, E Schutyser, E Schutyser, ER Delong, GM Pastores, Hermann Mascher, I Kurt, I Maire, J Wittmann, Jan Lukas, JE Groener, JE Groener, JM Aerts, K Nakamura, KL Chang, L van Dussen, Matthias Wittstock, MH Zweig, N Dekker, O Nilsson, OA Bodamer, PJ Orchard, PJ Seeman, Rayk Hübner, RG Boot, RY Wang, S Atsumi, S Aviner, S Struyf, T Taketomi, Tobias Böttcher, U Finckh, Ulrike Grittner, Uta Gölnitz, Wolfgang Meyer, XY Mao, Y Sun   +51 more
core   +7 more sources

Early and strong antibody responses to SARS-CoV-2 predict disease severity in COVID-19 patients

Journal of Translational Medicine, 2022
Background Antibody response to SARS-CoV-2 is a valuable biomarker for the assessment of the spread of the virus in a population and evaluation of the vaccine candidates. Recent data suggest that antibody levels also may have a prognostic significance in
Jānis Plūme, Artis Galvanovskis, Sindija Šmite, Nadezhda Romanchikova, Pawel Zayakin, Aija Linē   +5 more
doaj   +1 more source

Quantitative single-cell analysis of immunofluorescence protein multiplex images illustrates biomarker spatial heterogeneity within breast cancer subtypes

Breast Cancer Research, 2021
Background The extent of cellular heterogeneity in breast cancer could have potential impact on diagnosis and long-term outcome. However, pathology evaluation is limited to biomarker immunohistochemical staining and morphology of the bulk cancer.
Alison Min-Yan Cheung, Dan Wang, Kela Liu, Tyna Hope, Mayan Murray, Fiona Ginty, Sharon Nofech-Mozes, Anne Louise Martel, Martin Joel Yaffe   +8 more
doaj   +1 more source

Anatomy of an extinction revealed by molecular fossils spanning OAE2

Scientific Reports, 2021
The Cenomanian–Turonian mass extinction (Oceanic Anoxic Event 2-OAE2) was a period of profound ecological change that is recorded in the sedimentary record in many locations around the globe.
R. M. Forkner, J. Dahl, A. Fildani, S. M. Barbanti, I. A. Yurchenko, J. M. Moldowan   +5 more
doaj   +1 more source

Soluble guanylate cyclase signalling mediates etoposide resistance in progressing small cell lung cancer

Nature Communications, 2021
The emergence of acquired resistance to standard platinum-etoposide chemotherapy in small cell lung cancer (SCLC) is a common event. Here, the authors using paired pre-treatment and post-chemotherapy circulating tumour cell patient-derived explant (CDX ...
Maximilian W. Schenk, Sam Humphrey, A. S. Md Mukarram Hossain, Mitchell Revill, Sarah Pearsall, Alice Lallo, Stewart Brown, Samuel Bratt, Melanie Galvin, Tine Descamps, Cong Zhou, Simon P. Pearce, Lynsey Priest, Michelle Greenhalgh, Anshuman Chaturvedi, Alastair Kerr, Fiona Blackhall, Caroline Dive, Kristopher K. Frese   +18 more
doaj   +1 more source

Biomarker profiles of acute heart failure patients with a mid-range ejection fraction [PDF]

, 2017
OBJECTIVES: In this study, the authors used biomarker profiles to characterize differences between patients with acute heart failure with a midrange ejection fraction (HFmrEF) and compare them with patients with a reduced (heart failure with a ...
Bloomfield, Daniel M, Cleland, John G.F., Cotter, Gad, Davison, Beth, Dittrich, Howard C, Givertz, Michael M, Hillege, Hans L, Khan, Mohsin A F, Mentz, Robert J, Metra, Marco, O'Connor, Christopher M, Ponikowski, Piotr, Teerlink, John R, Tromp, Jasper, van der Meer, Peter, Van Veldhuisen, Dirk J, Voors, Adriaan A.   +16 more
core   +2 more sources

Exploiting the noise: improving biomarkers with ensembles of data analysis methodologies. [PDF]

, 2012
BackgroundThe advent of personalized medicine requires robust, reproducible biomarkers that indicate which treatment will maximize therapeutic benefit while minimizing side effects and costs.
Boutros, Paul C, Der, Sandy D, John, Thomas, Jurisica, Igor, Lambin, Philippe, Pintilie, Melania, Shepherd, Frances A, Starmans, Maud Hw, Tsao, Ming-Sound   +8 more
core   +2 more sources

Quality assessment and interference detection in targeted mass spectrometry data using machine learning

Clinical Proteomics, 2018
Advances in the field of targeted proteomics and mass spectrometry have significantly improved assay sensitivity and multiplexing capacity. The high-throughput nature of targeted proteomics experiments has increased the rate of data production, which ...
Shadi Toghi Eshghi, Paul Auger, W. Rodney Mathews   +2 more
doaj   +1 more source