Results 1 to 10 of about 2,411,306 (333)

Immune microenvironment characteristics in multiple myeloma progression from transcriptome profiling

Frontiers in Oncology, 2022
Multiple myeloma (MM) is characterized by clonal expansion of malignant plasma cells in the bone marrow (BM). Despite the significant advances in treatment, relapsed and refractory MM has not yet been completely cured due to the immune dysfunction in the
Jin Wang, Yi Hu, Habib Hamidi, Cedric Dos Santos, Jingyu Zhang, Elizabeth Punnoose, Wenjin Li   +6 more
doaj   +1 more source

Cell segmentation for immunofluorescence multiplexed images using two-stage domain adaptation and weakly labeled data for pre-training

Scientific Reports, 2022
Cellular profiling with multiplexed immunofluorescence (MxIF) images can contribute to a more accurate patient stratification for immunotherapy. Accurate cell segmentation of the MxIF images is an essential step.
Wenchao Han, Alison M. Cheung, Martin J. Yaffe, Anne L. Martel   +3 more
doaj   +1 more source

DunedinPACE, a DNA methylation biomarker of the pace of aging

eLife, 2021
Background: Measures to quantify changes in the pace of biological aging in response to intervention are needed to evaluate geroprotective interventions for humans.
Daniel W Belsky, A. Caspi, D. Corcoran, K. Sugden, R. Poulton, L. Arseneault, A. Baccarelli, K. Chamarti, Xu Gao, E. Hannon, H. Harrington, R. Houts, M. Kothari, D. Kwon, J. Mill, J. Schwartz, P. Vokonas, Cuicui Wang, Benjamin S. Williams, T. Moffitt   +19 more
semanticscholar   +1 more source

Biomarker profiles of acute heart failure patients with a mid-range ejection fraction [PDF]

, 2017
OBJECTIVES: In this study, the authors used biomarker profiles to characterize differences between patients with acute heart failure with a midrange ejection fraction (HFmrEF) and compare them with patients with a reduced (heart failure with a ...
Bloomfield, Daniel M, Cleland, John G.F., Cotter, Gad, Davison, Beth, Dittrich, Howard C, Givertz, Michael M, Hillege, Hans L, Khan, Mohsin A F, Mentz, Robert J, Metra, Marco, O'Connor, Christopher M, Ponikowski, Piotr, Teerlink, John R, Tromp, Jasper, van der Meer, Peter, Van Veldhuisen, Dirk J, Voors, Adriaan A.   +16 more
core   +7 more sources

Quantitative single-cell analysis of immunofluorescence protein multiplex images illustrates biomarker spatial heterogeneity within breast cancer subtypes

Breast Cancer Research, 2021
Background The extent of cellular heterogeneity in breast cancer could have potential impact on diagnosis and long-term outcome. However, pathology evaluation is limited to biomarker immunohistochemical staining and morphology of the bulk cancer.
Alison Min-Yan Cheung, Dan Wang, Kela Liu, Tyna Hope, Mayan Murray, Fiona Ginty, Sharon Nofech-Mozes, Anne Louise Martel, Martin Joel Yaffe   +8 more
doaj   +1 more source

Early and strong antibody responses to SARS-CoV-2 predict disease severity in COVID-19 patients

Journal of Translational Medicine, 2022
Background Antibody response to SARS-CoV-2 is a valuable biomarker for the assessment of the spread of the virus in a population and evaluation of the vaccine candidates. Recent data suggest that antibody levels also may have a prognostic significance in
Jānis Plūme, Artis Galvanovskis, Sindija Šmite, Nadezhda Romanchikova, Pawel Zayakin, Aija Linē   +5 more
doaj   +1 more source

Plasma p-tau231: a new biomarker for incipient Alzheimer’s disease pathology

Acta Neuropathologica, 2021
The quantification of phosphorylated tau in biofluids, either cerebrospinal fluid (CSF) or plasma, has shown great promise in detecting Alzheimer’s disease (AD) pathophysiology.
N. Ashton, T. Pascoal, T. Karikari, A. Benedet, J. Lantero‐Rodriguez, G. Brinkmalm, A. Snellman, M. Schöll, C. Troakes, Abdul Hye, S. Gauthier, E. Vanmechelen, H. Zetterberg, P. Rosa-Neto, K. Blennow   +14 more
semanticscholar   +1 more source

Development of a highly sensitive chemiluminescence immunoassay for quantification of aggrecanase-generated ARGS aggrecan fragments in serum

Osteoarthritis and Cartilage Open, 2021
Objective: Cartilage degradation is a hallmark of osteoarthritis (OA). Aggrecan, a major proteoglycan of articular cartilage extracellular matrix (ECM), is degraded by ADAMTS-5 resulting in the release of ARGS-G2 fragments to synovial fluid and ...
Yi He, Kamilla E. Jensen, Anne Sofie Siebuhr, Morten A. Karsdal, Jonathan Larkin, Anne C. Bay-Jensen   +5 more
doaj   +1 more source

Hematologic, biochemical and immune biomarker abnormalities associated with severe illness and mortality in coronavirus disease 2019 (COVID-19): a meta-analysis

Clinical Chemistry and Laboratory Medicine, 2020
Background As coronavirus disease 2019 (COVID-19) pandemic rages on, there is urgent need for identification of clinical and laboratory predictors for progression towards severe and fatal forms of this illness.
B. Henry, M. H. S. de Oliveira, S. Benoit, M. Plebani, G. Lippi   +4 more
semanticscholar   +1 more source

Calprotectin: from biomarker to biological function

Gut, 2021
The incidence of inflammatory bowel diseases (IBD) emerged with Westernisation of dietary habits worldwide. Crohn’s disease and ulcerative colitis are chronic debilitating conditions that afflict individuals with substantial morbidity and challenge ...
A. Jukic, L. Bakiri, E. Wagner, H. Tilg, T. Adolph   +4 more
semanticscholar   +1 more source