Results 91 to 100 of about 746,277 (164)
Ranking Biomarkers Through Mutual Information [PDF]
arXiv, 2016 We study information theoretic methods for ranking biomarkers. In clinical trials there are two, closely related, types of biomarkers: predictive and prognostic, and disentangling them is a key challenge. Our first step is to phrase biomarker ranking in terms of optimizing an information theoretic quantity. This formalization of the problem will enable
arxiv
Cancer biomarker development from basic science to clinical practice [PDF]
, 2018 The amount of published literature on biomarkers has exponentially increased over the last two decades. Cancer biomarkers are molecules that are either part of tumour cells or secreted by tumour cells.
Ali, Asif +3 more
core
Combining Biomarkers by Maximizing the True Positive Rate for a Fixed False Positive Rate [PDF]
arXiv, 2019 Biomarkers abound in many areas of clinical research, and often investigators are interested in combining them for diagnosis, prognosis, or screening. In many applications, the true positive rate for a biomarker combination at a prespecified, clinically acceptable false positive rate is the most relevant measure of predictive capacity.
arxiv
Alternative Complement Pathway Inhibition by Lampalizumab
Ophthalmology Science, 2023 Purpose: Lampalizumab, an antigen-binding fragment of a humanized monoclonal antibody directed against complement factor D (CFD), is designed to treat geographic atrophy (GA) secondary to age-related macular degeneration.
Rose Edmonds, MS +3 more
doaj
Frontiers in Chemistry, 2017 In this study, we synthesized manganese dioxide nanoparticles (MnO2 NPs) stabilized with biocompatible polymers (polyvinylpyrrolidone and polyacrylic acid) and analyzed their effect on non-small cell lung cancer (NSCLC) cells with or without gefitinib ...
Mi Hyeon Cho +4 more
doaj +1 more source
Machine Learning Driven Biomarker Selection for Medical Diagnosis [PDF]
arXivRecent advances in experimental methods have enabled researchers to collect data on thousands of analytes simultaneously. This has led to correlational studies that associated molecular measurements with diseases such as Alzheimer's, Liver, and Gastric Cancer.
arxiv
Fused Detection of Retinal Biomarkers in OCT Volumes [PDF]
arXiv, 2019 Optical Coherence Tomography (OCT) is the primary imaging modality for detecting pathological biomarkers associated to retinal diseases such as Age-Related Macular Degeneration. In practice, clinical diagnosis and treatment strategies are closely linked to biomarkers visible in OCT volumes and the ability to identify these plays an important role in ...
arxiv
The Role of the Complement Pathway in Clinical Progression of Geographic Atrophy
Ophthalmology Science, 2023 Purpose: To investigate the relationship between complement pathway activities and progression of geographic atrophy (GA) secondary to age-related macular degeneration in samples collected from patients enrolled in the Chroma and Spectri trials.
Rose Edmonds, MS +3 more
doaj
Validation of a Multivariate Serum Profile for Epithelial Ovarian Cancer Using a Prospective Multi-Site Collection [PDF]
, 2010 In previous studies we described the use of a retrospective collection of ovarian cancer and benign disease samples, in combination with a large set of multiplexed immunoassays and a multivariate pattern recognition algorithm, to develop an 11-biomarker ...
Beth Y. Karlan +20 more
core +1 more source
Lignin pyrolysis products: Their structures and their significance as biomarkers [PDF]
, 1986 Cesáreo Sáiz‐Jiménez, J.W. de Leeuw
openalex +1 more source