Results 91 to 100 of about 2,295,331 (380)

Neurofilament light chain as a biomarker in neurological disorders

Journal of Neurology Neurosurgery & Psychiatry, 2019
In the management of neurological diseases, the identification and quantification of axonal damage could allow for the improvement of diagnostic accuracy and prognostic assessment.
L. Gaetani, K. Blennow, P. Calabresi, M. Di Filippo, L. Parnetti, H. Zetterberg   +5 more
semanticscholar   +1 more source

An immune-based biomarker signature is associated with mortality in COVID-19 patients

JCI Insight, 2020
Immune and inflammatory responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) contribute to disease severity of coronavirus disease 2019 (COVID-19).
M. Abers, O. Delmonte, Emily E. Ricotta, J. Fintzi, D. Fink, A. D. de Jesus, K. Zarember, S. Alehashemi, Vasileios Oikonomou, Jigar V. Desai, S. Canna, B. Shakoory, K. Dobbs, L. Imberti, A. Sottini, E. Quiros-Roldan, F. Castelli, Camillo Rossi, D. Brugnoni, A. Biondi, L. Bettini, M. D'Angiò, P. Bonfanti, R. Castagnoli, D. Montagna, A. Licari, G. Marseglia, Emily F. Gliniewicz, E. Shaw, Dana Kahle, Andre T. Rastegar, M. Stack, Katherine Myint-Hpu, S. Levinson, M. Dinubile, Daniel S. Chertow, P. Burbelo, J. Cohen, K. Calvo, J. Tsang, H. Su, J. Gallin, D. Kuhns, R. Goldbach-Mansky, M. Lionakis, L. Notarangelo   +45 more
semanticscholar   +1 more source

Cancer cell death induced by the NAD antimetabolite Vacor discloses the antitumor potential of SARM1

FEBS Letters, EarlyView.
Vacor, a compound converted into the toxic metabolite Vacor adenine dinucleotide (VAD) by the nicotinamide salvage pathway enzymes NAMPT and NMNAT2, exhibits antitumor activity by inducing rapid and complete NAD depletion. We report that Vacor toxicity is limited to cell lines expressing high levels of SARM1, a NAD glycohydrolase.
Giuseppe Ranieri, Andrea Lapucci, Giuseppe Orsomando, Nadia Raffaelli, Alberto Chiarugi, Daniela Buonvicino   +5 more
wiley   +1 more source

Biomarkers of dissociation

BJPsych Open, 2023
Summary Dissociative symptoms present transdiagnostically and are related to poor clinical outcome. Research into the biological correlates of dissociation remains limited. This editorial summarises and discusses papers from this themed series of BJPsych Open that contribute to unravelling the biological correlates of dissociative symptomatology ...
Antje A. T. S. Reinders, Allan H. Young, Dick J. Veltman   +2 more
openaire   +4 more sources

Efficient Principally Stratified Treatment Effect Estimation in Crossover Studies with Absorbent Binary Endpoints [PDF]

, 2019
Suppose one wishes to estimate the effect of a binary treatment on a binary endpoint conditional on a post-randomization quantity in a counterfactual world in which all subjects received treatment.
Luedtke, Alex, Wu, Jiacheng
core   +1 more source

Association of Blood Biomarkers With Acute Sport-Related Concussion in Collegiate Athletes: Findings From the NCAA and Department of Defense CARE Consortium [PDF]

, 2020
Importance: There is potential scientific and clinical value in validation of objective biomarkers for sport-related concussion (SRC). Objective: To investigate the association of acute-phase blood biomarker levels with SRC in collegiate athletes.
Broglio, Steven P., Brooks, M. Alison, Cameron, Kenneth L., Campbell, Darren E., CARE Consortium Investigators, DiFiori, Jon, Duma, Stephan, Foroud, Tatiana, Gill, Jessica, Giza, Christopher C., Goldman, Joshua, Guskiewicz, Kevin, Harezlak, Jaroslaw, Houston, Megan N., Huber, Daniel L., Jackson, Jonathan C., Katz, Barry P., McAllister, Thomas W., McCrea, Michael, McGinty, Gerald, Meier, Timothy B., Mihalik, Jason, Nelson, Lindsay D., Pasquina, Paul, Rowson, Steven, Saykin, Andrew J., Svoboda, Steven J.   +26 more
core   +1 more source

Biophysical analysis of angiotensin II and amyloid‐β cross‐interaction in aggregation and membrane disruption

FEBS Letters, EarlyView.
Angiotensin II (AngII), a neuropeptide, interacts with amyloid‐β (Aβ), a key player in Alzheimer's disease. This study reveals that AngII reduces Aβ aggregation and membrane disruption in vitro. Biophysical assays and molecular modeling suggest AngII binds disordered Aβ forms, potentially modulating early amyloidogenic events and contributing to ...
Mohsen Habibnia, Eric Catalina‐Hernandez, Maialen Cabrerizo‐Idiazabal, Ramon Barnadas‐Rodríguez, Mario Lopez‐Martin, Alex Peralvarez‐Marin   +5 more
wiley   +1 more source

Biomarkers of the Dementia [PDF]

International Journal of Alzheimer’s Disease, 2011
Recent advances in biomarker studies on dementia are summarized here. CSF Aβ40, Aβ42, total tau, and phosphorylated tau are the most sensitive biomarkers for diagnosis of Alzheimer′s disease (AD) and prediction of onset of AD from mild cognitive impairment (MCI).
openaire   +2 more sources

A cfDNA methylation-based tissue-of-origin classifier for cancers of unknown primary

Nature Communications
Cancers of Unknown Primary (CUP) remains a diagnostic and therapeutic challenge due to biological heterogeneity and poor responses to standard chemotherapy.
Alicia-Marie Conway, Simon P. Pearce, Alexandra Clipson, Steven M. Hill, Francesca Chemi, Dan Slane-Tan, Saba Ferdous, A. S. Md Mukarram Hossain, Katarzyna Kamieniecka, Daniel J. White, Claire Mitchell, Alastair Kerr, Matthew G. Krebs, Gerard Brady, Caroline Dive, Natalie Cook, Dominic G. Rothwell   +16 more
doaj   +1 more source

Fine-grained cell-type specific association studies with human bulk brain data using a large single-nucleus RNA sequencing based reference panel

Scientific Reports, 2023
Brain disorders are leading causes of disability worldwide. Gene expression studies provide promising opportunities to better understand their etiology but it is critical that expression is studied on a cell-type level.
Edwin J. C. G. van den Oord, Karolina A. Aberg   +1 more
doaj   +1 more source