Results 111 to 120 of about 2,411,306 (333)

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Investigating neonatal health risk variables through cell-type specific methylome-wide association studies

Clinical Epigenetics
Adverse neonatal outcomes are a prevailing risk factor for both short- and long-term mortality and morbidity in infants. Given the importance of these outcomes, refining their assessment is paramount for improving prevention and care.
Thomas L. Campbell, Lin Y. Xie, Ralen H. Johnson, Christina M. Hultman, Edwin J. C. G. van den Oord, Karolina A. Aberg   +5 more
doaj   +1 more source

Development of an in vitro model to study the role of disulfide bonds in the largest extracellular domain of the sodium-dependent phosphate transporter NaPi2b in OVCAR-8 ovarian carcinoma cells

Успехи молекулярной онкологии
Introduction. The sodium-dependent phosphate transporter NaPi2b is a promising target for targeted antitumor therapy. There is the largest extracellular domain (ECD) containing a cryptic MX35 epitope, against which therapeutic antibodies have been ...
V. S. Skripova, D. A. Firsova, A. V. Kilunov, L. F. Bulatova, M. A. Poputsky, R. G. Kiyamova   +5 more
doaj   +1 more source

Detection of Alzheimer's disease at mild cognitive impairment and disease progression using autoantibodies as blood‐based biomarkers

Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, 2016
Introduction There is an urgent need to identify biomarkers that can accurately detect and diagnose Alzheimer's disease (AD). Autoantibodies are abundant and ubiquitous in human sera and have been previously demonstrated as disease‐specific biomarkers ...
Cassandra A. DeMarshall, Eric P. Nagele, Abhirup Sarkar, Nimish K. Acharya, George Godsey, Eric L. Goldwaser, Mary Kosciuk, Umashanger Thayasivam, Min Han, Benjamin Belinka, Robert G. Nagele, Alzheimer's Disease Neuroimaging Initiative   +11 more
doaj   +1 more source

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

Mining nucleic acid “omics” to boost liquid biopsy in cancer

Cell Reports Medicine
Summary: Treatments for cancer patients are becoming increasingly complex, and there is a growing desire from clinicians and patients for biomarkers that can account for this complexity to support informed decisions about clinical care.
Ann Tivey, Rebecca J. Lee, Alexandra Clipson, Steven M. Hill, Paul Lorigan, Dominic G. Rothwell, Caroline Dive, Florent Mouliere   +7 more
doaj   +1 more source

Identification of the shared mechanisms and common biomarkers between Sjögren’s syndrome and atherosclerosis using integrated bioinformatics analysis [PDF]

, 2023
Xiaoyi Qi, Qianwen Huang, Shijia Wang, Liangxian Qiu, Xiongbiao Chen, Kunfu Ouyang, Yanjun Chen   +6 more
openalex   +1 more source

Cerebrospinal Fluid Tau, p-Tau 181 and Amyloid-beta(38/40/42) in Frontotemporal Dementias and Primary Progressive Aphasias [PDF]

, 2010
Background/Aims: We determined cerebrospinal fluid (CSF) concentrations of amyloid-beta(A beta)(1-38), A beta(1-40), A beta(1-42), total tau and phospho-tau (p-tau) in order to study their differential expression in frontotemporal dementia (FTD, n = 25 ...
Bibl, Mirko, Esselmann, Hermann, Kornhuber, Johannes, Lewczuk, Piotr, Mollenhauer, Brit, Otto, Markus, Rüther, Eckart, Wiltfang, Jens, Wolf, Stefanie   +8 more
core   +1 more source

Revisiting biomarker discovery by plasma proteomics

Molecular Systems Biology, 2017
Clinical analysis of blood is the most widespread diagnostic procedure in medicine, and blood biomarkers are used to categorize patients and to support treatment decisions.
Philipp E. Geyer, L. Holdt, D. Teupser, M. Mann   +3 more
semanticscholar   +1 more source

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source