Results 31 to 40 of about 2,411,306 (333)

A targeted solution for estimating the cell-type composition of bulk samples

BMC Bioinformatics, 2021
Background To avoid false-positive findings and detect cell-type specific associations in methylation and transcription investigations with bulk samples, it is critical to know the proportions of the major cell-types.
Edwin J. C. G. van den Oord, Lin Y. Xie, Charles J. Tran, Min Zhao, Karolina A. Aberg   +4 more
doaj   +1 more source

Building Data-Driven Pathways From Routinely Collected Hospital Data:A Case Study on Prostate Cancer [PDF]

, 2015
Background: Routinely collected data in hospitals is complex, typically heterogeneous, and scattered across multiple Hospital Information Systems (HIS).
Adriansyah, A, Cios, KJ, Holmström, Benny, Lang, M, Luc, Kd, Mans, R, Mans, R, Pearson, SD, Safran, C   +8 more
core   +7 more sources

Tumor immune microenvironment and genomic evolution in a patient with metastatic triple negative breast cancer and a complete response to atezolizumab

Journal for ImmunoTherapy of Cancer, 2019
Background Metastatic TNBC (mTNBC) has a poor prognosis and few treatment options. The anti-PD-L1 antibody atezolizumab demonstrated clinical activity in mTNBC patients with PD-L1-positive tumor-infiltrating immune cells.
Luciana Molinero, Yijin Li, Ching-Wei Chang, Sophia Maund, Maureen Berg, Jeanne Harrison, Marcella Fassò, Carol O’Hear, Priti Hegde, Leisha A. Emens   +9 more
doaj   +1 more source

High serum granulocyte-colony stimulating factor characterises neutrophilic COPD exacerbations associated with dysbiosis

ERJ Open Research, 2021
Introduction COPD exacerbations are heterogeneous and can be triggered by bacterial, viral, or noninfectious insults. Exacerbations are also heterogeneous in neutrophilic or eosinophilic inflammatory responses.
Arindam Chakrabarti, Jordan S. Mar, David F. Choy, Yi Cao, Nisha Rathore, Xiaoying Yang, Gaik W. Tew, Olga Li, Prescott G. Woodruff, Christopher E. Brightling, Michele Grimbaldeston, Stephanie A. Christenson, Mona Bafadhel, Carrie M. Rosenberger   +13 more
doaj   +1 more source

Biomarkers in solid organ transplantation: establishing personalized transplantation medicine. [PDF]

, 2011
Technological advances in molecular and in silico research have enabled significant progress towards personalized transplantation medicine. It is now possible to conduct comprehensive biomarker development studies of transplant organ pathologies ...
Khatri, Purvesh, Roedder, Silke, Sarwal, Minnie M, Vitalone, Matthew   +3 more
core   +3 more sources

Smell dysfunction: a biomarker for COVID‐19

International Forum of Allergy and Rhinology, 2020
Severe acute respiratory syndrome‐coronavirus‐2 (SARS‐CoV‐2), the virus that causes coronavirus disease 2019 (COVID‐19), is responsible for the largest pandemic since the 1918 influenza A virus subtype H1N1 influenza outbreak.
S. T. Moein, S. Hashemian, Babak Mansourafshar, Ali Khorram-Tousi, P. Tabarsi, R. Doty   +5 more
semanticscholar   +1 more source

The application of Aptamer in biomarker discovery

Biomarker Research, 2023
Biomarkers are detectable molecules that can reflect specific physiological states of cells, organs, and organisms and therefore be regarded as indicators for specific diseases. And the discovery of biomarkers plays an essential role in cancer management
Yongshu Li, Winnie Wailing Tam, Yuanyuan Yu, Zhenjian Zhuo, Zhichao Xue, Chiman Tsang, X. Qiao, Xiaokang Wang, Weijing Wang, Yongyi Li, Yanyang Tu, Yunhua Gao   +11 more
semanticscholar   +1 more source

Blood-brain barrier breakdown is an early biomarker of human cognitive dysfunction

Nature Medicine, 2018
Vascular contributions to cognitive impairment are increasingly recognized1–5 as shown by neuropathological6,7, neuroimaging4,8–11, and cerebrospinal fluid biomarker4,12 studies.
D. Nation, Melanie D. Sweeney, Axel Montagne, A. Sagare, Lina M. D’Orazio, M. Pachicano, F. Sepehrband, Amy R. Nelson, David P. Buennagel, M. Harrington, T. Benzinger, A. Fagan, J. Ringman, L. Schneider, J. Morris, H. Chui, Meng Law, A. Toga, B. Zlokovic   +18 more
semanticscholar   +1 more source

‘Long-COVID’: a cross-sectional study of persisting symptoms, biomarker and imaging abnormalities following hospitalisation for COVID-19

Thorax, 2020
Large numbers of people are being discharged from hospital following COVID-19 without assessment of recovery. In 384 patients (mean age 59.9 years; 62% male) followed a median 54 days post discharge, 53% reported persistent breathlessness, 34% cough and ...
S. Mandal, J. Barnett, S. Brill, Jeremy S. Brown, E. Denneny, S. Hare, M. Heightman, T. Hillman, J. Jacob, H. Jarvis, M. Lipman, S. Naidu, A. Nair, J. Porter, G. Tomlinson, J. Hurst   +15 more
semanticscholar   +1 more source

Quantitative Comparison of Conventional and t-SNE-guided Gating Analyses

Frontiers in Immunology, 2019
Dimensionality reduction using the t-Distributed Stochastic Neighbor Embedding (t-SNE) algorithm has emerged as a popular tool for visualizing high-parameter single-cell data.
Shadi Toghi Eshghi, Amelia Au-Yeung, Chikara Takahashi, Christopher R. Bolen, Maclean N. Nyachienga, Sean P. Lear, Cherie Green, W. Rodney Mathews, William E. O'Gorman   +8 more
doaj   +1 more source