The PD-1/PD-L1 Pathway: A Perspective on Comparative Immuno-Oncology
Animals, 2022 The programmed cell death protein 1/programmed death-ligand 1 (PD-1/PD-L1) pathway mainly attracted attention in immuno-oncology, leading to the development of immune checkpoint therapy.
Sandra Schöniger, Bharat Jasani
doaj +1 more source
Intratumoral heterogeneity analysis reveals hidden associations between protein expression losses and patient survival in clear cell renal cell carcinoma. [PDF]
, 2017 Intratumoral heterogeneity (ITH) is a prominent feature of kidney cancer. It is not known whether it has utility in finding associations between protein expression and clinical parameters. We used ITH that is detected by immunohistochemistry (IHC) to aid
Devarajan, Karthik +10 more
core +3 more sources
The Future will be Different than Today: Model Evaluation Considerations when Developing Translational Clinical Biomarker [PDF]
arXiv, 2021 Finding translational biomarkers stands center stage of the future of personalized medicine in healthcare. We observed notable challenges in identifying robust biomarkers as some with great performance in one scenario often fail to perform well in new trials (e.g. different population, indications). With rapid development in the clinical trial world (e.
arxiv
Enhanced inflammation and suppressed adaptive immunity in COVID-19 with prolonged RNA shedding
Cell Discovery, 2022 Little is known regarding why a subset of COVID-19 patients exhibited prolonged positivity of SARS-CoV-2 infection. Here, we found that patients with long viral RNA course (LC) exhibited prolonged high-level IgG antibodies and higher regulatory T (Treg ...
Xiaohua Tang +31 more
doaj +1 more source
Preventing dataset shift from breaking machine-learning biomarkers [PDF]
arXiv, 2021 Machine learning brings the hope of finding new biomarkers extracted from cohorts with rich biomedical measurements. A good biomarker is one that gives reliable detection of the corresponding condition. However, biomarkers are often extracted from a cohort that differs from the target population. Such a mismatch, known as a dataset shift, can undermine
arxiv
A systematic review of biomarkers for disease progression in Parkinson's disease [PDF]
, 2013 Peer reviewedPublisher ...
A Winogrodzka +33 more
core +2 more sources
Extracting Digital Biomarkers for Unobtrusive Stress State Screening from Multimodal Wearable Data [PDF]
arXiv, 2023 With the development of wearable technologies, a new kind of healthcare data has become valuable as medical information. These data provide meaningful information regarding an individual's physiological and psychological states, such as activity level, mood, stress, and cognitive health.
arxiv
Scientific ReportsEx vivo drug screening is a potentially powerful tool for the future of cancer care, but the accuracy of results is contingent on the culture model. Both monolayer (2D) and spheroid (3D) culture systems offer advantages, but given the differences in ...
Angela Florio +3 more
doaj +1 more source
Chapter Six. Conclusions and future implications [PDF]
, 2016 6.1 Summary of Findings 6.2 Future Biomarker and Diagnostics Researchhttps://digitalcommons.wustl.edu/tropicalenteropathybook/1007/thumbnail ...
Denno, Donna M +4 more
core +1 more source
Biomarkers of Tuberculosis Severity and Treatment Effect: A Directed Screen of 70 Host Markers in a Randomized Clinical Trial. [PDF]
, 2017 More efficacious treatment regimens are needed for tuberculosis, however, drug development is impeded by a lack of reliable biomarkers of disease severity and of treatment effect. We conducted a directed screen of host biomarkers in participants enrolled
Barbero, S +14 more
core +2 more sources