Results 51 to 60 of about 2,411,306 (333)

Direct isolation and characterization of circulating exosomes from biological samples using magnetic nanowires

Journal of Nanobiotechnology, 2019
Background Tumor-derived exosomes are gaining attention as important factors that facilitate communication between neighboring cells and manipulate cellular processes associated with cancer development or progression.
Jiyun Lim, Mihye Choi, HyungJae Lee, Young-Ho Kim, Ji-Youn Han, Eun Sook Lee, Youngnam Cho   +6 more
doaj   +1 more source

Neurofilament light chain as a biomarker in neurological disorders

Journal of Neurology Neurosurgery & Psychiatry, 2019
In the management of neurological diseases, the identification and quantification of axonal damage could allow for the improvement of diagnostic accuracy and prognostic assessment.
L. Gaetani, K. Blennow, P. Calabresi, M. Di Filippo, L. Parnetti, H. Zetterberg   +5 more
semanticscholar   +1 more source

Analytical evaluation of circulating tumor DNA sequencing assays

Scientific Reports
In China, circulating tumor DNA analysis is widely used and numerous assays are available. Systematic evaluation to help users make informed selections is needed.
Wenjin Li, Xiayu Huang, Rajesh Patel, Erica Schleifman, Shijing Fu, David S. Shames, Jingyu Zhang   +6 more
doaj   +1 more source

Validation of RNAi Silencing Efficiency Using Gene Array Data shows 18.5% Failure Rate across 429 Independent Experiments

Molecular Therapy: Nucleic Acids, 2016
No independent cross-validation of success rate for studies utilizing small interfering RNA (siRNA) for gene silencing has been completed before. To assess the influence of experimental parameters like cell line, transfection technique, validation method,
Gyöngyi Munkácsy, Zsófia Sztupinszki, Péter Herman, Bence Bán, Zsófia Pénzváltó, Nóra Szarvas, Balázs Győrffy   +6 more
doaj   +1 more source

Characterization of Cancer/Testis Antigens as Prognostic Markers of Ovarian Cancer

Diagnostics, 2023
The main goal of this study was to characterize cancer/testis antigens (CTAs) as potential molecular markers of ovarian cancer. First, we gathered and analyzed a significantly large dataset of 21 selected CTAs that are encoded by 32 genes; the dataset ...
Ramilia Vlasenkova, Daliya Konysheva, Alsina Nurgalieva, Ramziya Kiyamova   +3 more
doaj   +1 more source

Proteomics-on-a-chip for Biomarker discovery [PDF]

, 2007
In proteomics research still two-dimensional gel electrophoresis (2D-GE) is currently used for biomarker discovery. We applied free flow electrophoresis (FFE) separation technology combined with biomolecular interaction sensing using Surface Plasmon ...
Berg, Albert van den, Eijkel, Jan, Kohlheyer, Dietrich, Schasfoort, Richard B.M., Schlautmann, Stefan   +4 more
core   +1 more source

Addressing the needs of traumatic brain injury with clinical proteomics. [PDF]

, 2014
BackgroundNeurotrauma or injuries to the central nervous system (CNS) are a serious public health problem worldwide. Approximately 75% of all traumatic brain injuries (TBIs) are concussions or other mild TBI (mTBI) forms.
Loo, Joseph A, Loo, Rachel R Ogorzalek, Shen, Sean, Wanner, Ina-Beate   +3 more
core   +1 more source

Potential Early Risk Biomarkers for Reduced Forced Expiratory Volume in Children Post‐Hematopoietic Cell Transplantation

Pediatric Blood &Cancer, EarlyView.
ABSTRACT We sought to identify potential early risk biomarkers for lung disease in children post‐allogeneic HCT. Patients with pulmonary function tests 3 months post‐transplant and plasma samples between days 7 and 14 post‐HCT were included. Six of 27 subjects enrolled had reduced forced expiratory volume 1 (FEV1) z scores.
Isabella S. Small, Pi Chun Cheng, April L. Rahrig, Courtney M. Rowan   +3 more
wiley   +1 more source

The role of PD-L1 expression as a predictive biomarker: an analysis of all US Food and Drug Administration (FDA) approvals of immune checkpoint inhibitors

Journal of Immunotherapy for Cancer, 2019
The development of immune checkpoint inhibitors has changed the treatment paradigm for advanced cancers across many tumor types. Despite encouraging and sometimes durable responses in a subset of patients, most patients do not respond.
A. Davis, V. Patel
semanticscholar   +1 more source

Nutritional and Behavioral Intervention for Long‐Term Childhood Acute Leukemia Survivors With Metabolic Syndrome

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Purpose Metabolic syndrome (MetS) is a common complication in survivors of childhood acute lymphoblastic and myeloid leukemia (AL), and a major risk factor for premature cardiovascular disease, type‐2‐diabetes, and metabolic dysfunction‐associated steatotic liver disease (MASLD).
Visentin Sandrine, Béliard Sophie, Renard Cécile, Caussy Cyrielle, Hamidou Zeinab, Romano David, Gacem Mélanie, Petit Arnaud, Saultier Paul, Borentain Patrick, Michel Gérard   +10 more
wiley   +1 more source