Results 61 to 70 of about 2,295,331 (380)

Atezolizumab plus bevacizumab combination enables an unresectable hepatocellular carcinoma resectable and links immune exclusion and tumor dedifferentiation to acquired resistance

Experimental Hematology & Oncology, 2021
We reported a patient with unresectable hepatocellular carcinoma (HCC) who initially received 15 cycles of atezolizumab plus bevacizumab combination and had best tumor response of partial response, but later experienced disease progression.
Yulei Wang, Li-Chun Lu, Yinghui Guan, Ming-Chih Ho, Shan Lu, Jessica Spahn, Chih-Hung Hsu   +6 more
doaj   +1 more source

Direct isolation and characterization of circulating exosomes from biological samples using magnetic nanowires

Journal of Nanobiotechnology, 2019
Background Tumor-derived exosomes are gaining attention as important factors that facilitate communication between neighboring cells and manipulate cellular processes associated with cancer development or progression.
Jiyun Lim, Mihye Choi, HyungJae Lee, Young-Ho Kim, Ji-Youn Han, Eun Sook Lee, Youngnam Cho   +6 more
doaj   +1 more source

Characterization of Cancer/Testis Antigens as Prognostic Markers of Ovarian Cancer

Diagnostics, 2023
The main goal of this study was to characterize cancer/testis antigens (CTAs) as potential molecular markers of ovarian cancer. First, we gathered and analyzed a significantly large dataset of 21 selected CTAs that are encoded by 32 genes; the dataset ...
Ramilia Vlasenkova, Daliya Konysheva, Alsina Nurgalieva, Ramziya Kiyamova   +3 more
doaj   +1 more source

Addressing the needs of traumatic brain injury with clinical proteomics. [PDF]

, 2014
BackgroundNeurotrauma or injuries to the central nervous system (CNS) are a serious public health problem worldwide. Approximately 75% of all traumatic brain injuries (TBIs) are concussions or other mild TBI (mTBI) forms.
Loo, Joseph A, Loo, Rachel R Ogorzalek, Shen, Sean, Wanner, Ina-Beate   +3 more
core   +1 more source

Biomarkers in sepsis [PDF]

Current Opinion in Pulmonary Medicine, 2013
This review discusses the current developments in biomarkers for sepsis.With quantum leaps in technology, an array of biomarkers will become available within the next decade as point-of-care tools that will likely revolutionize the management of sepsis.
openaire   +4 more sources

Analytical evaluation of circulating tumor DNA sequencing assays

Scientific Reports
In China, circulating tumor DNA analysis is widely used and numerous assays are available. Systematic evaluation to help users make informed selections is needed.
Wenjin Li, Xiayu Huang, Rajesh Patel, Erica Schleifman, Shijing Fu, David S. Shames, Jingyu Zhang   +6 more
doaj   +1 more source

Validation of RNAi Silencing Efficiency Using Gene Array Data shows 18.5% Failure Rate across 429 Independent Experiments

Molecular Therapy: Nucleic Acids, 2016
No independent cross-validation of success rate for studies utilizing small interfering RNA (siRNA) for gene silencing has been completed before. To assess the influence of experimental parameters like cell line, transfection technique, validation method,
Gyöngyi Munkácsy, Zsófia Sztupinszki, Péter Herman, Bence Bán, Zsófia Pénzváltó, Nóra Szarvas, Balázs Győrffy   +6 more
doaj   +1 more source

Proteomics-on-a-chip for Biomarker discovery [PDF]

, 2007
In proteomics research still two-dimensional gel electrophoresis (2D-GE) is currently used for biomarker discovery. We applied free flow electrophoresis (FFE) separation technology combined with biomolecular interaction sensing using Surface Plasmon ...
Berg, Albert van den, Eijkel, Jan, Kohlheyer, Dietrich, Schasfoort, Richard B.M., Schlautmann, Stefan   +4 more
core   +1 more source

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

FEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro, Marco Cellani, Cristina Scielzo   +2 more
wiley   +1 more source

DNA repair deficiency biomarkers and the 70-gene ultra-high risk signature as predictors of veliparib/carboplatin response in the I-SPY 2 breast cancer trial. [PDF]

, 2017
Veliparib combined with carboplatin (VC) was an experimental regimen evaluated in the biomarker-rich neoadjuvant I-SPY 2 trial for breast cancer. VC showed improved efficacy in the triple negative signature.
Berry, Don, Brown-Swigart, Lamorna, Buxton, Meredith, DeMichele, Angela, Esserman, Laura, Glas, Annuska, Hirst, Gillian, Hylton, Nola, Linn, Sabine, Olopade, Olufunmilayo, Paoloni, Melissa, Petricoin, Emanuel, Rugo, Hope, Sanil, Ashish, Severson, Tesa M, Symmans, Fraser, van 't Veer, Laura, Wolf, Denise M, Wulfkuhle, Julia, Yau, Christina, Yee, Doug   +20 more
core   +2 more sources