Results 61 to 70 of about 746,277 (164)

Joint Modeling of Biomarker Cascades Along An Unobserved Disease Progression with Differentiate Covariate Effects: An Application in Alzheimer's Disease [PDF]

arXiv, 2023
Alzheimer's Disease (AD) research has shifted to focus on biomarker trajectories and their potential use in understanding the underlying AD-related pathological process. A conceptual framework was proposed in modern AD research that hypothesized biomarker cascades as a result of underlying AD pathology.
arxiv  

DNA repair deficiency biomarkers and the 70-gene ultra-high risk signature as predictors of veliparib/carboplatin response in the I-SPY 2 breast cancer trial. [PDF]

, 2017
Veliparib combined with carboplatin (VC) was an experimental regimen evaluated in the biomarker-rich neoadjuvant I-SPY 2 trial for breast cancer. VC showed improved efficacy in the triple negative signature.
Berry, Don, Brown-Swigart, Lamorna, Buxton, Meredith, DeMichele, Angela, Esserman, Laura, Glas, Annuska, Hirst, Gillian, Hylton, Nola, Linn, Sabine, Olopade, Olufunmilayo, Paoloni, Melissa, Petricoin, Emanuel, Rugo, Hope, Sanil, Ashish, Severson, Tesa M, Symmans, Fraser, van 't Veer, Laura, Wolf, Denise M, Wulfkuhle, Julia, Yau, Christina, Yee, Doug   +20 more
core   +2 more sources

Investigating neonatal health risk variables through cell-type specific methylome-wide association studies

Clinical Epigenetics
Adverse neonatal outcomes are a prevailing risk factor for both short- and long-term mortality and morbidity in infants. Given the importance of these outcomes, refining their assessment is paramount for improving prevention and care.
Thomas L. Campbell, Lin Y. Xie, Ralen H. Johnson, Christina M. Hultman, Edwin J. C. G. van den Oord, Karolina A. Aberg   +5 more
doaj   +1 more source

Detection of Alzheimer's disease at mild cognitive impairment and disease progression using autoantibodies as blood‐based biomarkers

Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, 2016
Introduction There is an urgent need to identify biomarkers that can accurately detect and diagnose Alzheimer's disease (AD). Autoantibodies are abundant and ubiquitous in human sera and have been previously demonstrated as disease‐specific biomarkers ...
Cassandra A. DeMarshall, Eric P. Nagele, Abhirup Sarkar, Nimish K. Acharya, George Godsey, Eric L. Goldwaser, Mary Kosciuk, Umashanger Thayasivam, Min Han, Benjamin Belinka, Robert G. Nagele, Alzheimer's Disease Neuroimaging Initiative   +11 more
doaj   +1 more source

Asymptotic properties of the sequential empirical ROC, PPV and NPV curves under case-control sampling

, 2012
The receiver operating characteristic (ROC) curve, the positive predictive value (PPV) curve and the negative predictive value (NPV) curve are three measures of performance for a continuous diagnostic biomarker.
Feng, Ziding, Koopmeiners, Joseph S.
core   +1 more source

A network analysis to compare biomarker profiles in patients with and without diabetes mellitus in acute heart failure [PDF]

, 2017
Aims: It is unclear whether distinct pathophysiological processes are present among patients with acute heart failure (AHF), with and without diabetes.
Bloomfield, Daniel M., Cleland, John G.F., Cotter, Gad, Davison, Beth A., Demissei, Biniyam G., Dittrich, Howard, Ezekowitz, Justin A., Givertz, Michael M., Hillege, Hans L., Khan, Mohsin A.F., Metra, Marco, O'Connor, Christopher M., Ponikowski, Piotr, Sharma, Abhinav, Teerlink, John R., Tromp, Jasper, van Veldhuisen, Dirk J., Voors, Adriaan A.   +17 more
core   +2 more sources

Clinical Contrastive Learning for Biomarker Detection [PDF]

NeurIPS 2022 Workshop: Self-Supervised Learning - Theory and Practice, 2022
This paper presents a novel positive and negative set selection strategy for contrastive learning of medical images based on labels that can be extracted from clinical data. In the medical field, there exists a variety of labels for data that serve different purposes at different stages of a diagnostic and treatment process.
arxiv  

Development of an in vitro model to study the role of disulfide bonds in the largest extracellular domain of the sodium-dependent phosphate transporter NaPi2b in OVCAR-8 ovarian carcinoma cells

Успехи молекулярной онкологии
Introduction. The sodium-dependent phosphate transporter NaPi2b is a promising target for targeted antitumor therapy. There is the largest extracellular domain (ECD) containing a cryptic MX35 epitope, against which therapeutic antibodies have been ...
V. S. Skripova, D. A. Firsova, A. V. Kilunov, L. F. Bulatova, M. A. Poputsky, R. G. Kiyamova   +5 more
doaj   +1 more source

From aptamer-based biomarker discovery to diagnostic and clinical applications: an aptamer-based, streamlined multiplex proteomic assay [PDF]

, 2010
Recently, we reported an aptamer-based, highly multiplexed assay for the purpose of biomarker identification. To enable seamless transition from highly multiplexed biomarker discovery assays to a format suitable and convenient for diagnostic and life ...
Christopher Bock, Dom Zichi, Evaldas Katilius, Glenn M. Sanders, Jonathon D. Vaught, Larry Gold, Nancy Kim, Nicholas A. Saccomano, Sheri K. Wilcox, Stephan Kraemer, Tracy R. Keeney   +10 more
core   +1 more source

Expert consensus on population-based BRCA germline mutation screening in China (2024 edition) [PDF]

Zhongguo aizheng zazhi
Germline mutations in BRCA genes (including BRCA1/2) are the major risk factors for hereditary tumors including breast and ovarian cancer. Population based BRCA gene screening, particularly in high-risk individuals with a family history of cancer, can ...
China Anti-Cancer Association Tumor Biomarker Professional Committee, Shanghai Anti-Cancer Association Tumor Biomarker Professional Committee
doaj   +1 more source