Results 61 to 70 of about 2,411,306 (333)

Expert consensus on population-based BRCA germline mutation screening in China (2024 edition) [PDF]

Zhongguo aizheng zazhi
Germline mutations in BRCA genes (including BRCA1/2) are the major risk factors for hereditary tumors including breast and ovarian cancer. Population based BRCA gene screening, particularly in high-risk individuals with a family history of cancer, can ...
China Anti-Cancer Association Tumor Biomarker Professional Committee, Shanghai Anti-Cancer Association Tumor Biomarker Professional Committee
doaj   +1 more source

The tale of TILs in breast cancer: A report from The International Immuno-Oncology Biomarker Working Group

npj Breast Cancer, 2021
The advent of immune-checkpoint inhibitors (ICI) in modern oncology has significantly improved survival in several cancer settings. A subgroup of women with breast cancer (BC) has immunogenic infiltration of lymphocytes with expression of programmed ...
K. El Bairi, H. R. Haynes, E. Blackley, S. Fineberg, J. Shear, Sophia Turner, Juliana Ribeiro de Freitas, Daniel G Sur, L. C. Amendola, M. Gharib, A. Kallala, I. Arun, Farid Azmoudeh-Ardalan, L. Fujimoto, L. Sua, Shiwei Liu, H. Lien, Pawan Kirtani, M. Balancin, Hicham El Attar, Prerna Guleria, Wenxian Yang, Emad Shash, I. Chen, V. Bautista, Jose Fernando Prado Moura, B. Rapoport, C. Castañeda, E. Spengler, Gabriela Acosta-Haab, I. Frahm, Joselyn Sanchez, Miluska Castillo, Najat Bouchmaa, R. R. Md Zin, R. Shui, T. Onyuma, Wentao Yang, Z. Husain, K. Willard-Gallo, A. Coosemans, E. Perez, E. Provenzano, P. G. Ericsson, E. Richardet, R. Mehrotra, Sandra Sarancone, A. Ehinger, D. Rimm, J. Bartlett, G. Viale, C. Denkert, A. Hida, C. Sotiriou, S. Loibl, S. Hewitt, S. Badve, W. Symmans, Rim S. Kim, G. Pruneri, S. Goel, P. Francis, G. Inurrigarro, R. Yamaguchi, H. García-Rivello, H. Horlings, S. Afqir, R. Salgado, S. Adams, M. Kok, M. Dieci, S. Michiels, S. Demaria, S. Loi, The International Immuno-Oncology Biomarker Working Group   +74 more
semanticscholar   +1 more source

Survival for Children Diagnosed With Wilms Tumour (2012–2022) Registered in the UK and Ireland Improving Population Outcomes for Renal Tumours of Childhood (IMPORT) Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background The Improving Population Outcomes for Renal Tumours of childhood (IMPORT) is a prospective clinical observational study capturing detailed demographic and outcome data on children and young people diagnosed with renal tumours in the United Kingdom and the Republic of Ireland.
Naomi Ssenyonga, Angela Lopez‐Cortes, Reem Al‐Saadi, Suzanne Tugnait, Kristina Dzhuma, Catriona Duncan, Gordan Vujanic, Tanzina Chowdhury, Claudia Allemani, Michel P. Coleman, Kathy Pritchard‐Jones, the Children's Cancer and Leukaemia Group (CCLG) Renal Tumour Special Interest Group, Hugh Bishop, Anthony McCarthy, Pamela Kearns, Helen Rees, Amos Burke, Meriel Jenney, Jane Pears, Hamish Wallace, Milind Ronghe, Tanzina Chowdhury, Susan Picton, Emma Ross, Lisa Howell, Bernadette Brennan, Gail Halliday, Richard Grundy, Shaun Wilson, Sucheta Vaidya, Daniel Yeomanson, Jessica Bate, Vesna Pavasovic, Jessica Bate, Sabine Irtan, Jesper Brok, Minou Oostveen, Kristina Dzhuma, Mark Weeks, Richard Williams, Mark Powis, Max Pachl, Bruce Okoye, Naima Smeulders, Gordan Vujanic, Oystein Olsen, Tom Watson, Susan Shelmerdine, Dan Saunders, Angela Lopez-Cortes, Taryn Treger, Tom Jackson, Suzanne Tugnait, Lisa Howell, Tanzina Chowdhury, Sam Behjati, Angela Polanco   +56 more
wiley   +1 more source

Modern spatial sea-ice variability in the central Arctic Ocean and adjacent marginal seas: Reconstruction from biomarker data [PDF]

, 2012
Sea ice is a fundamental component of Earth’s climate system, contributing to heat reduction (albedo) and deep-water formation. In order to understand processes controlling the recent dramatic reduction in Arctic sea-ice cover, it is essential to ...
Fahl, Kirsten, Meheust, Marie, Müller, Juliane, Stein, Rüdiger, Xiao, Xiaotong   +4 more
core  

Periostin as a biomarker of airway inflammation [PDF]

, 2016
No abstract ...
Johnstone, Steven, McSharry, Charles
core   +1 more source

The MedSupport Multilevel Intervention to Enhance Support for Pediatric Medication Adherence: Development and Feasibility Testing

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Introduction We developed MedSupport, a multilevel medication adherence intervention designed to address root barriers to medication adherence. This study sought to explore the feasibility and acceptability of the MedSupport intervention strategies to support a future full‐scale randomized controlled trial.
Elizabeth G. Bouchard, Hital Patel, Paula C. Vincent, Justine Kahn, Kira Bona, Thai Hoa Tran, Elisa M. Rodriguez, Kristopher Attwood, Kara M. Kelly   +8 more
wiley   +1 more source

Integrated digital pathology and transcriptome analysis identifies molecular mediators of T-cell exclusion in ovarian cancer

Nature Communications, 2020
The exclusion of T cells from solid tumours is a potentially important mechanism that regulates whether or not cancer patients respond well to checkpoint blocking immunotherapies.
Mélanie Desbois, Akshata R. Udyavar, Lisa Ryner, Cleopatra Kozlowski, Yinghui Guan, Milena Dürrbaum, Shan Lu, Jean-Philippe Fortin, Hartmut Koeppen, James Ziai, Ching-Wei Chang, Shilpa Keerthivasan, Marie Plante, Richard Bourgon, Carlos Bais, Priti Hegde, Anneleen Daemen, Shannon Turley, Yulei Wang   +18 more
doaj   +1 more source

Alternative Complement Pathway Inhibition by Lampalizumab

Ophthalmology Science, 2023
Purpose: Lampalizumab, an antigen-binding fragment of a humanized monoclonal antibody directed against complement factor D (CFD), is designed to treat geographic atrophy (GA) secondary to age-related macular degeneration.
Rose Edmonds, MS, Verena Steffen, MSc, Lee A. Honigberg, PhD, Michael C. Chang, PhD   +3 more
doaj   +1 more source

Prolonged Corrected QT Interval as an Early Electrocardiographic Marker of Cyclophosphamide‐Induced Cardiotoxicity in Pediatric Hematology and Oncology Patients

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Cyclophosphamide (CY) is associated with potentially fatal cardiotoxicity, yet no electrocardiographic indices have been established for early detection of CY‐induced cardiomyopathy. This study aimed to determine whether corrected QT interval (QTc) prolongation can predict early onset of CY‐related cardiac dysfunction in pediatric ...
Junpei Kawamura, Kentaro Ueno, Takuro Nishikawa, Yoshihiro Takahashi, Koji Nakae, Yasuhiro Okamoto   +5 more
wiley   +1 more source

Tumor ploidy determination in low-pass whole genome sequencing and allelic copy number visualization using the Constellation Plot

Genome Biology
Ploidy determination across the genome has been challenging for low-pass-WGS tumor-only samples. We present BACDAC, a method that calculates tumor ploidy down to 1.2X effective tumor coverage.
Sarah H. Johnson, James B. Smadbeck, Roman M. Zenka, Michael T. Barrett, Athanasios Gaitatzes, Arnav Solanki, Angela B. Florio, Mitesh J. Borad, John C. Cheville, George Vasmatzis   +9 more
doaj   +1 more source