Results 71 to 80 of about 2,018,528 (308)

First exploration of the on-treatment changes in tumor and organ uptake of a radiolabeled anti PD-L1 antibody during chemoradiotherapy in patients with non-small cell lung cancer using whole body PET

Journal for ImmunoTherapy of Cancer
Background In patients with locally advanced unresectable non-small cell lung cancer (NSCLC), durvalumab, an anti-programmed cell death ligand-1 (PD-L1) antibody, has shown improved overall survival when used as consolidation therapy following concurrent
Tanja D de Gruijl, Teodora Radonic, Marc C Huisman, Idris Bahce, Johanna E E Pouw, Sayed M S Hashemi, Jessica E Wijngaarden, Maarten Slebe, Daniela E Oprea-Lager, Gerben J C Zwezerijnen, Danielle Vugts, Ezgi B Ulas, Suresh Senan, C Willemien Menke-van der Houven van Oordt   +13 more
doaj   +1 more source

Preliminary evidence supports circulating microRNAs as prognostic biomarkers for type 2 diabetes. [PDF]

, 2017
Background:Circulating microRNAs are emerging as potential prognostic biomarkers for the development of type 2 diabetes. However, microRNAs are also associated with complications from impaired glucose metabolism (e.g. endothelial cell function).
Allen, IE, Aouizerat, BE, Cooper, B, Flowers, E, Fukuoka, Y, Kanaya, AM   +5 more
core   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Vitamin D Receptor Gene Polymorphisms Modify Cardiometabolic Response to Vitamin D Supplementation in T2DM Patients

Scientific Reports, 2017
There is conflicting evidence on the favorable effects of vitamin D supplementation on metabolic profile in Type 2 diabetes mellitus (T2DM) patients and this might be due to genetic variations in vitamin D receptors (VDRs). Thus, we studied the metabolic
Nasser M. Al-Daghri, Abdul Khader Mohammed, Omar S. Al-Attas, Mohammed Ghouse Ahmed Ansari, Kaiser Wani, Syed D. Hussain, Shaun Sabico, Gyanendra Tripathi, Majed S. Alokail   +8 more
doaj   +1 more source

Characterization of retinal function and structure in the MPTP murine model of Parkinson’s disease

Scientific Reports, 2022
In addition to well characterized motor symptoms, visual disturbances are increasingly recognized as an early manifestation in Parkinson’s disease (PD). A better understanding of the mechanisms underlying these changes would facilitate the development of
Katie K. N. Tran, Vickie H. Y. Wong, Jeremiah K. H. Lim, Ali Shahandeh, Anh Hoang, David I. Finkelstein, Bang V. Bui, Christine T. O. Nguyen   +7 more
doaj   +1 more source

Prognostic importance of emerging cardiac, inflammatory, and renal biomarkers in chronic heart failure patients with reduced ejection fraction and anaemia: RED-HF study [PDF]

, 2018
Aims: To test the prognostic value of emerging biomarkers in the Reduction of Events by Darbepoetin Alfa in Heart Failure (RED-HF) trial. Methods and results: Circulating cardiac [N-terminal pro-B-type natriuretic peptide (NT-proBNP), and high ...
Alehagen, Arimoto, Balling, Bolignano, Cabassi, Dupont, Gaggin, Gravning, Grodin, Guisado Espartero, Haehling, Harrell, Jackson, Lassus, Lassus, Lok, Maisel, Maisel, McMurray, McMurray, Miller, Miller, Nagarajan, Park, Pascual-Figal, Pencina, Pencina, Pocock, Ponikowski, Rahimi, Rush, Shlipak, Swedberg, Tentzeris, Zamora   +34 more
core   +4 more sources

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Exploiting a new strategy to induce immunogenic cell death to improve dendritic cell-based vaccines for lymphoma immunotherapy

OncoImmunology, 2017
Although promising, the clinical benefit provided by dendritic cell (DC)-based vaccines is still limited and the choice of the optimal antigen formulation is still an unresolved issue.
B. Montico, C. Lapenta, M. Ravo, D. Martorelli, E. Muraro, B. Zeng, E. Comaro, M. Spada, S. Donati, S. M. Santini, R. Tarallo, G. Giurato, F. Rizzo, A. Weisz, F. Belardelli, R. Dolcetti, J. Dal Col   +16 more
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Serum Metabolic Alterations upon Zika Infection

Frontiers in Microbiology, 2017
Zika virus (ZIKV) infection has recently emerged as a major concern worldwide due to its strong association with nervous system malformation (microcephaly) of fetuses in pregnant women infected by the virus. Signs and symptoms of ZIKV infection are often
Carlos Fernando O. R. Melo, Jeany Delafiori, Diogo N. de Oliveira, Tatiane M. Guerreiro, Cibele Z. Esteves, Estela de O. Lima, Victoria Pando-Robles, Rodrigo R. Catharino, the Zika-Unicamp Network, Guilherme P. Milanez, Gabriela M. do Nascimento, André R. R. Freitas, Rodrigo Angerami, Fábio T. Maranhão Costa, Clarice W. Arns, Mariangela R. Resende, Eliana Amaral, Renato P. Junior, Carolina C. Ribeiro-do-Valle, Helaine Milanez, Maria L. Moretti, Jose L. Proenca-Modena, Glaucia M. Pastore, Kleber Y. Fertrin, Márcia T. Garcia, Roseli Calil, João R. B. Júnior, Giuliane J. Lajos, Maria L. Costa, Marcos T. N. da Silva, Albina Altemani, Ana C. Coan, Maria F. Colella-Santos, Andrea P. B. von Zuben, Marco A. R. Vinolo, Rosemeire F. de O. de Paula, Carla C. Judice, Juliana A. Leite, Leonardo C. Caserta, Ana P. de Moraes, Ana C. S. Barnabé, Ana L. R. da Soledade, Daniel A. T. Teixeira, Évellyn R. de Morais, Felipe R. Santos   +44 more
doaj   +1 more source