Results 61 to 70 of about 1,486,593 (315)

Nephrogenic Rests/Nephroblastomatosis in Patients With Unilateral Wilms Tumor Are Not Associated With an Increased Risk of Relapse: An Analysis of Patients Treated on the SIOP‐WT‐2001 Protocol in the SIOP‐UK‐CCLG and SIOP‐GPOH Studies (2001–2022)

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Introduction Nephrogenic rests (NRs) and nephroblastomatosis (NBM) are precursor lesions for development of Wilms tumor (WT). Their association with the risk of relapse has not been properly assessed, partly due to misunderstanding of their diagnostic criteria and terminology.
Gordan M. Vujanić, Rhoikos Furtwängler, Tanzina Chowdhury, Christian Vokuhl, Jenny Wegert, Norbert Graf   +5 more
wiley   +1 more source

Discovery and validation of cell cycle arrest biomarkers in human acute kidney injury [PDF]

, 2013
Introduction: Acute kidney injury (AKI) can evolve quickly and clinical measures of function often fail to detect AKI at a time when interventions are likely to provide benefit.
Vinsonneau, Christophe, McCullough, Peter A., Thomas Ardiles, Kim, Patrick, R Gentry Wilkerson, Gernot Marx, Lissauer, Matthew E, Laskowitz, Daniel T, Nathan I Shapiro, Shapiro, Nathan I., Wilkerson, R. Gentry, Christophe Vinsonneau, Ardiles, Thomas, Robert Birkhahn, Gong, Michelle, Hackett, James, Koyner, Jay L, Ostermann, Marlies, Jing Shi, John A Kellum, Hoste, Eric A. J., Chawla, Lakhmir S., Joannes-Boyau, Olivier, Olivier Joannes-Boyau, Sean M Bagshaw, Scott Mullaney, Hoste, Eric, Kellum, John A, Kellum, John A., Wagner, Ludwig, Michael Haase, Birkhahn, Robert, Zacharowski, Kai, Hoste, Eric AJ, Michael G Walker, Al-Khafaji, Ali, Bagshaw, Sean M., Sprague, Amy M, Davison, Danielle L., Michelle Gong, Bell, Max, Gunnerson, Kyle J., Koyner, Jay L., Shi, Jing, Feldkamp, Thorsten, Jean-Louis Vincent, Davison, Danielle L, Daniel T Laskowitz, Ludwig Wagner, Walker, Michael G., Forni, Lui G., Honore, Patrick M, Marx, Germot, Matthew E Lissauer, Ali Al-Khafaji, Jay L Koyner, James Hackett, Eric AJ Hoste, Patrick Kim, Sprague, Amy M., Azra Bihorac, Honore, Patrick M., Kashani, Kianoush, Haase, Michael, Artigas, Antonio, Cely, Cynthia M, Forni, Lui G, Andrew D Shaw, Thomas Rimmelé, Shaw, Andrew D, Bagshaw, Sean M, Kyle J Gunnerson, Kai Zacharowski, Danielle L Davison, Joannidis, Michael, Patrick M Honore, Peter A McCullough, Cynthia M Cely, Marx, Gernot, Shaw, Andrew D., Lakhmir S Chawla, Rimmelé, Thomas, Antonio Artigas, Bihorac, Azra, Vincent, Jean-Louis, Laskowitz, Daniel T., Wilkerson, R Gentry, Walker, Michael G, Max Bell, Mullaney, Scott, Amy M Sprague, McCullough, Peter A, Michael Joannidis, Gunnerson, Kyle J, Cely, Cynthia M., Shapiro, Nathan I, Thorsten Feldkamp, Marlies Ostermann, Gong, Michelle Ng, Lui G Forni, Kianoush Kashani, Lissauer, Matthew E., Chawla, Lakhmir S   +102 more
core   +1 more source

DNA Methylation Biomarkers for Prediction of Response to Platinum-Based Chemotherapy: Where Do We Stand? [PDF]

, 2022
SIMPLE SUMMARY: Platinum-based agents are one of the most widely used chemotherapy drugs for various types of cancer. However, one of the main challenges in the application of platinum drugs is resistance, which is currently being widely investigated ...
Tavares, Nuno Tiago, Jerónimo, Carmen, Rui Henrique, Henrique, Rui, Saulė Gumauskaitė, Carmen Jerónimo, Gumauskaitė, Saulė, Lobo, João, Nuno Tiago Tavares, João Lobo   +9 more
core   +1 more source

Serum Myonectin Levels Are Positively Associated With Physical Function and Lower Frailty‐Related Limitation in Maintenance Hemodialysis Patients: A Cross‐Sectional Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Maintenance hemodialysis (MHD) patients frequently suffer from frailty, characterized by reduced physical function and poor prognosis. Myokines, such as myonectin, secreted by muscle, are emerging regulators of systemic health. This study investigated the relationship between serum myonectin, adipokines (adiponectin, omentin), and ...
Kenichi Kono, Yoshifumi Moriyama, Koji Ohashi, Naoya Otaka, Minako Tatsumi, Toyoaki Murohara, Noriyuki Ouchi, Satoru Oshima   +7 more
wiley   +1 more source

Sprifermin (rhFGF18) modulates extracellular matrix turnover in cartilage explants ex vivo

Journal of Translational Medicine, 2017
Background Sprifermin (recombinant human fibroblast growth factor 18) is in clinical development as a potential disease-modifying osteoarthritis drug (DMOAD).
Ditte Reker, Cecilie F. Kjelgaard-Petersen, Anne Sofie Siebuhr, Martin Michaelis, Anne Gigout, Morten A. Karsdal, Christoph Ladel, Anne C. Bay-Jensen   +7 more
doaj   +1 more source

Comparative metabolomic profiling of women undergoing in vitro fertilization procedures reveals potential infertility-related biomarkers in follicular fluid

Scientific Reports, 2022
Infertility is a worldwide concern, affecting one in six couples throughout their reproductive period. Therefore, enhancing the clinical tools available to identify the causes of infertility may save time, money, and emotional distress for the involved ...
Mohamed Ziad Dabaja, Aline Amaro dos Santos, Denise Maria Christofolini, Caio Parente Barbosa, Diogo Noin de Oliveira, Arthur Noin de Oliveira, Carlos Fernando Odir Rodrigues Melo, Tatiane Melina Guerreiro, Rodrigo Ramos Catharino   +8 more
doaj   +1 more source

Comparative Evaluation of Hemodiafiltration, Hemoperfusion, and Standard Hemodialysis on Efficacy, Inflammatory Control, Dialysis Adequacy, and Safety in End‐Stage Renal Disease: A Prospective Observational Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Chronic micro‐inflammation in patients with end‐stage renal disease (ESRD) is a significant driver of cardiovascular complications and diminished quality of life. While standard hemodialysis (SHD) effectively manages small‐molecule clearance, its ability to remove medium‐to‐large uremic toxins—the primary catalysts of systemic ...
Hongwei Zuo, Weisi Dai, Jie Mao, Mei Ye, Xingshan Lu, Xiaocui Zhang   +5 more
wiley   +1 more source

RNA Biomarkers as a Response Measure for Survival in Patients with Metastatic Castration-Resistant Prostate Cancer [PDF]

, 2021
Treatment evaluation in metastatic castration-resistant prostate cancer is challenging. There is an urgent need for biomarkers to discriminate short-term survivors from long-term survivors, shortly after treatment initiation.
Irma M. Oving, Paul Hamberg, Vincent O. Dezentjé, Nielka P. van Erp, Levi Groen, Niven Mehra, Jack A. Schalken, Guillemette E. Benoist, Inge M. van Oort, Gerald W. Verhaegh, Emmy Boerrigter, Onno van Hooij, Pieter de Mol, Tineke J. Smilde, Anton F. J. de Haan, Frank Smit, Diederik M. Somford   +16 more
core   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Extracellular matrix remodeling proteins as biomarkers for clinical assessment and treatment outcomes in eosinophilic esophagitis

BMC Gastroenterology, 2023
Background Eosinophilic esophagitis (EoE) is a chronic progressive inflammatory disease of the esophagus, characterized by extracellular matrix remodeling and fibrotic stricture formation.
Martin Pehrsson, Willemijn E. de Rooij, Anne-Christine Bay-Jensen, Morten Asser Karsdal, Joachim Høg Mortensen, Albert Jan Bredenoord   +5 more
doaj   +1 more source