Results 41 to 50 of about 2,018,528 (308)

Wavelet feature extraction and genetic algorithm for biomarker detection in colorectal cancer data [PDF]

, 2012
Biomarkers which predict patient’s survival can play an important role in medical diagnosis and treatment. How to select the significant biomarkers from hundreds of protein markers is a key step in survival analysis.
Aickelin, Uwe, Durrant, Lindy G, Feyereisl, Jan, Liu, Yihui   +3 more
core   +3 more sources

Increased Drp1 promotes autophagy and ESCC progression by mtDNA stress mediated cGAS-STING pathway

Journal of Experimental & Clinical Cancer Research, 2022
Background Mitochondrial dynamics homeostasis is important for cell metabolism, growth, proliferation, and immune responses. The critical GTPase for mitochondrial fission, Drp1 is frequently upregulated in many cancers and is closely implicated in ...
Yujia Li, Hui Chen, Qi Yang, Lixin Wan, Jing Zhao, Yuanyuan Wu, Jiaxin Wang, Yating Yang, Menglan Niu, Hongliang Liu, Junqi Liu, Hushan Yang, Shaogui Wan, Yanming Wang, Dengke Bao   +14 more
doaj   +1 more source

Definition of valid proteomic biomarkers: a bayesian solution [PDF]

, 2009
Clinical proteomics is suffering from high hopes generated by reports on apparent biomarkers, most of which could not be later substantiated via validation.
C.C. Holmes, E. Check, E.F. Petricoin, H. Mischak, J. Albert, J. Jantos-Siwy, J.J. Coon, K. Bae, R.M. Everson, S. Decramer, S. Manocha   +10 more
core   +1 more source

NRASQ61R Expression in Lymphatic Endothelial Cells Causes Enlarged Vessels, Hemorrhagic Chylous Effusions, and High Mortality in a Mouse Model of Kaposiform Lymphangiomatosis

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Kaposiform lymphangiomatosis (KLA) is an aggressive complex lymphatic anomaly. Patients exhibit malformed lymphatic vessels and often develop hemorrhagic effusions and elevated angiopoietin‐2 (Ang‐2) levels. A somatic NRAS p.Q61R (NRASQ61R) mutation has been associated with KLA.
C. Griffin McDaniel, Patricia Pastura, Joshua P. Scallan, Timothy D. Le Cras   +3 more
wiley   +1 more source

Collagens and Cancer associated fibroblasts in the reactive stroma and its relation to Cancer biology

Journal of Experimental & Clinical Cancer Research, 2019
The extracellular matrix (ECM) plays an important role in cancer progression. It can be divided into the basement membrane (BM) that supports epithelial/endothelial cell behavior and the interstitial matrix (IM) that supports the underlying stromal ...
Neel I. Nissen, Morten Karsdal, Nicholas Willumsen   +2 more
doaj   +1 more source

Cancer biomarker development from basic science to clinical practice [PDF]

, 2018
The amount of published literature on biomarkers has exponentially increased over the last two decades. Cancer biomarkers are molecules that are either part of tumour cells or secreted by tumour cells.
Ali, Asif, Ali, Zafar, Oien, Karin A., Yousafzai, Yasar Mehmood   +3 more
core  

Myocardial Dysfunction in an Animal Model of Cancer Cachexia [PDF]

, 2011
Aims Fatigue is a common occurrence in cancer patients regardless of tumor type or anti-tumor therapies and is an especially problematic symptom in persons with incurable tumor disease.
Crawford, Danielle, Hutchinson, Kirk R., Lucchesi, Pamela A., McCarthy, Donna O., Velten, Markus, Wold, Loren E., Xu, Hui, Youtz, Dane J.   +7 more
core   +2 more sources

Two Faces of NOTCH1 in Childhood Lymphoblastic T‐Cell Neoplasia: Prognostic Divergence of Mutational and Structural Aberrations

Pediatric Blood &Cancer, EarlyView.
ABSTRACT In pediatric patients, T‐cell lymphoblastic lymphoma (T‐LBL) survival exceeds 80%. Relapse remains associated with limited curative options. Frontline treatment is largely extrapolated from T‐cell acute lymphoblastic leukemia (T‐ALL) treatment, reflecting the ongoing debate, whether both entities represent distinct diseases or variants within ...
Marie C. Heider, Amelie Alfert, Marc Hotfilder, Birgit Burkardt, Marcel te Vrugt   +4 more
wiley   +1 more source

Turnover of type I and III collagen predicts progression of idiopathic pulmonary fibrosis

Respiratory Research, 2021
Background Idiopathic pulmonary fibrosis (IPF) is characterized by the accumulation of fibrillar collagens in the alveolar space resulting in reduced pulmonary function and a high mortality rate.
H. Jessen, N. Hoyer, T. S. Prior, P. Frederiksen, M. A. Karsdal, D. J. Leeming, E. Bendstrup, J. M. B. Sand, S. B. Shaker   +8 more
doaj   +1 more source

Maximizing the benefits and minimizing the risks of intervention programs to address micronutrient malnutrition: symposium report. [PDF]

, 2016
Interventions to address micronutrient deficiencies have large potential to reduce the related disease and economic burden. However, the potential risks of excessive micronutrient intakes are often not well determined.
Bruins, Maaike J, Engle-Stone, Reina, Kraemer, Klaus, Kupka, Roland, Lietz, Georg, Zimmermann, Michael B   +5 more
core   +1 more source