Results 21 to 30 of about 1,640,663 (265)

The dual amylin and calcitonin receptor agonist KBP-089 and the GLP-1 receptor agonist liraglutide act complimentarily on body weight reduction and metabolic profile

BMC Endocrine Disorders, 2021
Background Weight loss therapy is becoming more and more important, and two classes of molecules, namely amylin receptor and GLP-1 receptor agonists, have shown promise in this regard.
Anna Thorsø Larsen, Sofie Gydesen, Nina Sonne, Morten Asser Karsdal, Kim Henriksen   +4 more
doaj   +1 more source

Determining cut-points for Alzheimer's disease biomarkers: statistical issues, methods and challenges. [PDF]

, 2012
New proposed criteria for the clinical diagnosis of Alzheimer's disease increasingly incorporate biomarkers, most of which are normally measured on a continuous scale. Operationalizing such criteria thus requires continuous biomarkers to be dichotomized,
Skillbäck, Tobias,, Blennow, Kaj,, Bartlett, Jonathan W, Zetterberg, Henrik,, Blennow, Kaj, Zetterberg, Henrik, Frost, Chris, Mattsson, Niklas, Skillbäck, Tobias, Schott, Jonathan M, Mattsson, Niklas,   +10 more
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Co-enrichment of CD8-positive T cells and macrophages is associated with clinical benefit of tislelizumab in solid tumors

Biomarker Research, 2023
Background Activated immune cells (IC) in the tumor microenvironment (TME) are critical for anti-tumor efficacy. Greater understanding of the dynamic diversity and crosstalk between IC is needed to clarify their association with immune checkpoint ...
Dingwei Ye, Jayesh Desai, Jingwen Shi, Si-Yang Maggie Liu, Wei Shen, Tengfei Liu, Yang Shi, Dan Wang, Liang Liang, Silu Yang, Xiaopeng Ma, Wei Jin, Pei Zhang, Ruiqi Huang, Zhirong Shen, Yun Zhang, Yi-Long Wu   +16 more
doaj   +1 more source

Integration of Proteomics, Bioinformatics and Systems biology in Brain Injury Biomarker Discovery

Frontiers in Neurology, 2013
Traumatic brain injury (TBI) is a major medical crisis without any FDA-approved pharmacological therapies that have been demonstrated to improve functional outcomes.
Joy eGuingab-Cagmat, Emilio eCagmat, Ronald L Hayes, John eAnagli   +3 more
doaj   +1 more source

Proteomic candidate biomarkers of drug-induced nephrotoxicity in the rat [PDF]

, 2012
Improved biomarkers of acute nephrotoxicity are coveted by the drug development industry, regulatory agencies, and clinicians. In an effort to identify such biomarkers, urinary peptide profiles of rats treated with two different nephrotoxins were ...
Hanig, J., Mischak, H., Harald Mischak (103627), Rouse Rodney, Mullen, W., Metzger, J., William Mullen (103621), Rodney Rouse, William Mullen, Jochen Metzger, Jochen Metzger (171762), Hanig Joseph, Siwy, J., Joseph Hanig, Justyna Siwy (103595), Mullen William, Harald Mischak, Rouse, R., Justyna Siwy, Rodney Rouse (171753), Metzger Jochen, Joseph Hanig (82484), Siwy Justyna, Mischak Harald   +23 more
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The potential of pathological protein fragmentation in blood-based biomarker development for dementia – with emphasis on Alzheimer’s disease

Frontiers in Neurology, 2015
The diagnosis of dementia is challenging and early stages are rarely detected limiting the possibilities for early interven-tion. Another challenge is the overlap in the clinical features across the different dementia types leading to difficulties in the
Dilek eInekci, Ditte Svendsen Jonesco, Sophie eKennard, Morten Asser Karsdal, Kim eHenriksen   +4 more
doaj   +1 more source

Cell surface membrane proteins as personalized biomarkers: where we stand and where we are headed [PDF]

, 2013
Personalized medicine requires the development of a wide array of biomarker diagnostic assays, reflecting individual variations and thus allowing tailored therapeutic interventions.
Szabó, Edit, Sarkadi, Balázs, Várady, György, Németh, Adrienn, Cserepes, Judit   +4 more
core   +1 more source

Update on Biomarkers Associated with Large-Artery Atherosclerosis Stroke

, 2023
Intracranial and extracranial large-artery atherosclerosis (LAA) are a main cause of ischemic stroke. Biomarkers may aid in the diagnosis of LAA and help to stratify patients’ risk of stroke.
Ana Catarina Fonseca, Madalena Rosário
core   +1 more source

Variability of the Genes Involved in the Cellular Redox Status and Their Implication in Drug Hypersensitivity Reactions

Antioxidants, 2021
Adverse drug reactions are a major cause of morbidity and mortality. Of the great diversity of drugs involved in hypersensitivity drug reactions, the most frequent are non-steroidal anti-inflammatory drugs followed by β-lactam antibiotics.
Pedro Ayuso, Elena García-Martín, José A. G. Agúndez   +2 more
doaj   +1 more source

The use of biomarkers for the etiologic diagnosis of MCI in Europe: an EADC survey [PDF]

, 2014
We investigated the use of Alzheimer's disease (AD) biomarkers in European Alzheimer's Disease Consortium centers and assessed their perceived usefulness for the etiologic diagnosis of mild cognitive impairment (MCI).
Erikdotter, M, Samantha Galluzzi, Peters, Oliver, Galluzi, S, Andreas Monsch, Jones, Roy W, Mehrabian, S., Zekry, Dina, Wilcock, G, Sarazin, M., Sánchez-Castellano, Carmen, Martinez-Lage, P, Kehoe, P.G., Wallin, Åsa,, Hallikainen, M., Monsch, A, Santana, I, Felician, O, Frolich, L, Rikkert, M.O., Isabel Santana, Wilcock, Gordon, Jean‐Marc Orgogozo, Flavio Nobili, Mecocci, P, Hausner, Lucrezia, Roy W. Jones, Jessen, F., Heuser, I., Isabell Heuser, Eric Salmon, David Wilkinson, Froelich, L., Félician, Olivier, Maria Eriksdotter, Ceccaldi, M, Sarazin, M, Olde Rikkert, Marcel, de Mendonca, A., Aguera, E., Galluzzi, Samantha, Felician, O., Pasquier, F., Patrick Gavin Kehoe, Wolf, H, Nordberg, Agneta, Shima Mehrabian, Latchezar Traykov, Frolich, L., Mira Didic, Dartigues, Jean François, Hasselbalch, S.G., Aguera, Eduardo, Alberto Lleo, Sarazin, Marie, Martina Bocchetta, Brian Lawlor, Wallin, Åsa K, Dartigues, J.F., Monsch, A., Magda Tsolaki, Wilkinson, D., Giovanni B. Frisoni, Sanchez-Castellano, C, Yener, Goersev, NOBILI, FLAVIO MARIANO, Nobili, Flavio, Eriksdotter, Maria, Bernabei, R, Hallikainen, M, Gertz, H.J., Frisoni, Giovanni B., Lleo, A, Eduardo Aguera, Hallikainen, Merja, Roberto Bernabei, Alexandre de Mendonça, Gordon Wilcock, Visser, Pieter Jelle, Bullock, R., Frisoni, G.B., Bernabei, Roberto, Jones, Roy W., Alexander Kurz, Sanchez-Castellano, C., Wallin, Åsa, Bochetta, M, Bullock, R, Martinez-Lage, P., Patrizia Mecocci, Frank Jessen, Lleo, Alberto, Ceccaldi, M., Pablo Martinez‐Lage, Nobili, F., Florence Pasquier, Salmon, E., Eriksdotter, M., Lawlor, B., de Mendonça, Alexandre, Dartigues, Jean-François, Jessen, F, Pasquier, Florence, Marie Sarazin, Lucrezia Hausner, Monsch, Andreas, Rikkert, Marcel Olde, Dina Zekry, Carmen Sánchez‐Castellano, Pasquier, F, Traykov, L., Didic, M., Tsolaki, M, Nordberg, A., Pieter Jelle Visser, Kehoe, Patrick Gavin, Orgogozo, J.M., Froelich, Lutz, Kurz, A, Nobili, F, Bocchetta, M., Lund University., Martinez-Lage, Pablo, Agneta Nordberg, Åsa K. Wallin, Frisoni, G. B., Hasselbalch, Steen G, Zekry, D., Wilkinson, D, Gertz, Hermann Josef, Ceccaldi, Mathieu, Galluzzi, S., Santana, Isabel, Wilcock, G., Lleo, A., Mehrabian, S, Kurz, A., Heuser, Isabell, Gertz, Hermann-Josef, Kurz, Alexander, Wilkinson, David, Jean‐François Dartigues, Oliver Peters, Hausner, L, Mecocci, Patrizia, Peters, O., Roger Bullock, Lutz Frölich, Frisoni, Giovanni B, Merja Hallikainen, Orgogozo, Jean Marc, Jones, R.W., Henrike Wolf, Nordberg, A, Mecocci, P., Olde Rikkert, M, Olivier Félician, Wolf, Henrike, Bullock, Roger, Yener, G, Wallin, Åsa K., Peters, O, Yener, Görsev, Wolf, H., Didic, Mira, Mathieu Ceccaldi, Hausner, L., de Mendonca, A, Lawlor, Brian, Jessen, Frank, Orgogozo, Jean-Marc, Bernabei, R., Marcel Olde Rikkert, Mendonca, A. de, Heuser, I, Mehrabian, Shima, Salmon, Eric, Traykov, L, Visser, P.J., Bocchetta, Martina, Aguera, E, Martinez Lage, Pablo, Frölich, Lutz, Hermann‐Josef Gertz, Steen G. Hasselbalch, Didic, M, Tsolaki, M., Tsolaki, Magda, Hasselbalch, Steen G., Santana, I., Hasselbach, S.G., Lawlor, B, Olde Rikkert, M.G.M., Yener, G., Görsev Yener, Wallin, A.K., Traykov, Latchezar, Sänchez Castellano, Carmen   +197 more
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