Results 11 to 20 of about 1,344,517 (267)
Haptoglobin as a Biomarker [PDF]
Biochemistry (Moscow), Supplement Series B: Biomedical Chemistry, 2021 Haptoglobin (Hp) is a blood plasma glycoprotein that binds free hemoglobin (Hb) and plays a critical role in tissue protection and the prevention of oxidative damage. In addition, it has a number of regulatory functions. Haptoglobin is an acute phase protein, its concentration in plasma changes in pathology, and the test for its concentration is ...
Naryzny, S. N., Legina, O. K.
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Heart Failure Clinics, 2012 Epidemiologic, clinical, and basic research has identified several antecedent conditions that predispose individuals to heart failure and its predecessor, asymptomatic left ventricular remodeling and dysfunction (stage B heart failure). Many biochemical markers have been described that characterize the remodeling process and the development of cardiac ...
Viorel G, Florea, Inder S, Anand
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Biomarkers of Cholestasis [PDF]
Biomarkers in Medicine, 2021 Cholestasis is a major pathological manifestation, often resulting in detrimental liver conditions, which occurs in a variety of indications collectively termed cholestatic liver diseases. The frequent asymptomatic character and complexity of cholestasis, together with the lack of a straightforward biomarker, hampers early detection and treatment of ...
Pieters, Alanah +5 more
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Imaging Biomarkers or Biomarker Imaging? [PDF]
Pharmaceuticals, 2014 Since biomarker imaging is traditionally understood as imaging of molecular probes, we highly recommend to avoid any confusion with the previously defined term “imaging biomarkers” and, therefore, only use “molecular probe imaging (MPI)” in that context. Molecular probes (MPs) comprise all kinds of molecules administered to an organism which inherently
Markus Mitterhauser, Wolfgang Wadsak
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BioMed Research International, 2014 Bloodstream infections are a major concern because of high levels of antibiotic consumption and of the increasing prevalence of antimicrobial resistance. Bacteraemia is identified in a small percentage of patients with signs and symptoms of sepsis. Biomarkers are widely used in clinical practice and they are useful for monitoring the infectious process.
Henriquez-Camacho, Cesar, Losa, Juan
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British Journal of Cancer, 2008 Within the era of molecularly targeted anticancer agents, it has become increasingly important to provide proof of mechanism as early on as possible in the drug development cycle, especially in the clinic. Selective activation of apoptosis is often cited as one of the major goals of cancer chemotherapy.
Ward, T. H. +7 more
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Journal of the Advanced Practitioner in Oncology, 2022 In the popular Biomarker Jeopardy session, Sandra E. Kurtin, PhD, ANP-C, AOCN®, Alyssa Henglefelt, PharmD, BCOP, and Haleigh Mistry, MS, PA-C, paired biomarkers with tumor types for which their expression is most commonly used to determine targeted therapy, identified key assays used to measure common biomarkers, and discussed guidelines for biomarker ...
Kurtin, Sandra E. +2 more
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Emerging Biomarkers for Immunotherapy in Glioblastoma
, 2022 Immunotherapy has shown clinical benefits in several solid malignancies—in particular, melanoma and non-small cell lung cancer. However, in other solid tumours such as glioblastoma (GBM), the response to immunotherapy has been more variable, and ...
Nadia Mensali, Else Marit Inderberg
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Journal of the Advanced Practitioner in Oncology, 2020 This JADPRO Live session tested attendees' knowledge on biomarkers and their use in determining targeted therapy for certain tumor types, key assays used to measure common biomarkers, and guideline-endorsed biomarker testing recommendations.
Held, Lauren +2 more
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Immunologic Biomarkers and Biomarkers for Immunotherapies in Gastrointestinal Cancer [PDF]
Visceral Medicine, 2019 Gastrointestinal (GI) cancers contribute significantly to the worldwide cancer burden. Pathologic evaluation is indispensable for the estimation of prognosis and therapeutic strategy. At present, immunotherapies are evolving into efficient therapeutic approaches, which are accompanied by the need for biomarkers to predict therapy response.
Martin, Benedikt, Märkl, Bruno
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