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Epidemiologic, clinical, and basic research has identified several antecedent conditions that predispose individuals to heart failure and its predecessor, asymptomatic left ventricular remodeling and dysfunction (stage B heart failure). Many biochemical markers have been described that characterize the remodeling process and the development of cardiac ...
Viorel G, Florea, Inder S, Anand
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Haptoglobin as a Biomarker [PDF]
Haptoglobin (Hp) is a blood plasma glycoprotein that binds free hemoglobin (Hb) and plays a critical role in tissue protection and the prevention of oxidative damage. In addition, it has a number of regulatory functions. Haptoglobin is an acute phase protein, its concentration in plasma changes in pathology, and the test for its concentration is ...
Naryzny, S. N., Legina, O. K.
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Biomarkers of Cholestasis [PDF]
Cholestasis is a major pathological manifestation, often resulting in detrimental liver conditions, which occurs in a variety of indications collectively termed cholestatic liver diseases. The frequent asymptomatic character and complexity of cholestasis, together with the lack of a straightforward biomarker, hampers early detection and treatment of ...
Pieters, Alanah +5 more
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Update on Biomarkers Associated with Large-Artery Atherosclerosis Stroke [PDF]
Intracranial and extracranial large-artery atherosclerosis (LAA) are a main cause of ischemic stroke. Biomarkers may aid in the diagnosis of LAA and help to stratify patients’ risk of stroke.
Ana Catarina Fonseca, Madalena Rosário
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Current Cancer Biomarkers [PDF]
Current Cancer Biomarkers is a comprehensive review on the status of biological markers for various types of cancer. It aims to update readers on current developments on the subject.
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Biomarkers and Lung Cancer Early Detection: State of the Art [PDF]
Lung cancer burden is increasing, with 2 million deaths/year worldwide. Current limitations in early detection impede lung cancer diagnosis when the disease is still localized and thus more curable by surgery or multimodality treatment.
Fabrizio Bianchi +6 more
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Emerging Biomarkers and the Changing Landscape of Small Cell Lung Cancer [PDF]
SIMPLE SUMMARY: Small cell lung cancer (SCLC) is an aggressive cancer representing 15% of all lung cancers. Unlike other types of lung cancer, treatments for SCLC have changed very little in the past 20 years and therefore, the survival rate remains low.
Anna Keogh +5 more
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Emerging Biomarkers for Immunotherapy in Glioblastoma [PDF]
Immunotherapy has shown clinical benefits in several solid malignancies—in particular, melanoma and non-small cell lung cancer. However, in other solid tumours such as glioblastoma (GBM), the response to immunotherapy has been more variable, and ...
Nadia Mensali, Else Marit Inderberg
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Imaging Biomarkers or Biomarker Imaging? [PDF]
Since biomarker imaging is traditionally understood as imaging of molecular probes, we highly recommend to avoid any confusion with the previously defined term “imaging biomarkers” and, therefore, only use “molecular probe imaging (MPI)” in that context. Molecular probes (MPs) comprise all kinds of molecules administered to an organism which inherently
Markus Mitterhauser, Wolfgang Wadsak
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Background Weight loss therapy is becoming more and more important, and two classes of molecules, namely amylin receptor and GLP-1 receptor agonists, have shown promise in this regard.
Anna Thorsø Larsen +4 more
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