Results 51 to 60 of about 1,640,663 (265)

GNL3 and PA2G4 as Prognostic Biomarkers in Prostate Cancer

, 2023
Prostate cancer is a multifocal and heterogeneous disease common in males and remains the fifth leading cause of cancer-related deaths worldwide. The prognosis of prostate cancer is variable and based on the degree of cancer and its stage at the time of ...
Shashank Kumar, Mohd Shuaib, Abdullah F. AlAsmari, Sanjay Gupta, Faleh Alqahtani   +4 more
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

The dual amylin and calcitonin receptor agonist KBP-336 elicits a unique combination of weight loss, antinociception and bone protection – a novel disease-modifying osteoarthritis drug

Arthritis Research & Therapy
Background Despite the extensive research to provide a disease-modifying osteoarthritis drug (DMOAD), there is still no approved DMOAD. Dual amylin and calcitonin receptor agonists (DACRA) can provide metabolic benefits along with antinociceptive and ...
Khaled Elhady Mohamed, Anna Thorsø Larsen, Simone Melander, Frederik Andersen, Ellen Barendorff Kerrn, Morten Asser Karsdal, Kim Henriksen   +6 more
doaj   +1 more source

Turnover of type I and III collagen predicts progression of idiopathic pulmonary fibrosis

Respiratory Research, 2021
Background Idiopathic pulmonary fibrosis (IPF) is characterized by the accumulation of fibrillar collagens in the alveolar space resulting in reduced pulmonary function and a high mortality rate.
H. Jessen, N. Hoyer, T. S. Prior, P. Frederiksen, M. A. Karsdal, D. J. Leeming, E. Bendstrup, J. M. B. Sand, S. B. Shaker   +8 more
doaj   +1 more source

Discovery and validation of cell cycle arrest biomarkers in human acute kidney injury [PDF]

, 2013
Introduction: Acute kidney injury (AKI) can evolve quickly and clinical measures of function often fail to detect AKI at a time when interventions are likely to provide benefit.
Vinsonneau, Christophe, McCullough, Peter A., Thomas Ardiles, Kim, Patrick, R Gentry Wilkerson, Gernot Marx, Lissauer, Matthew E, Laskowitz, Daniel T, Nathan I Shapiro, Shapiro, Nathan I., Wilkerson, R. Gentry, Christophe Vinsonneau, Ardiles, Thomas, Robert Birkhahn, Gong, Michelle, Hackett, James, Koyner, Jay L, Ostermann, Marlies, Jing Shi, John A Kellum, Hoste, Eric A. J., Chawla, Lakhmir S., Joannes-Boyau, Olivier, Olivier Joannes-Boyau, Sean M Bagshaw, Scott Mullaney, Hoste, Eric, Kellum, John A, Kellum, John A., Wagner, Ludwig, Michael Haase, Birkhahn, Robert, Zacharowski, Kai, Hoste, Eric AJ, Michael G Walker, Al-Khafaji, Ali, Bagshaw, Sean M., Sprague, Amy M, Davison, Danielle L., Michelle Gong, Bell, Max, Gunnerson, Kyle J., Koyner, Jay L., Shi, Jing, Feldkamp, Thorsten, Jean-Louis Vincent, Davison, Danielle L, Daniel T Laskowitz, Ludwig Wagner, Walker, Michael G., Forni, Lui G., Honore, Patrick M, Marx, Germot, Matthew E Lissauer, Ali Al-Khafaji, Jay L Koyner, James Hackett, Eric AJ Hoste, Patrick Kim, Sprague, Amy M., Azra Bihorac, Honore, Patrick M., Kashani, Kianoush, Haase, Michael, Artigas, Antonio, Cely, Cynthia M, Forni, Lui G, Andrew D Shaw, Thomas Rimmelé, Shaw, Andrew D, Bagshaw, Sean M, Kyle J Gunnerson, Kai Zacharowski, Danielle L Davison, Joannidis, Michael, Patrick M Honore, Peter A McCullough, Cynthia M Cely, Marx, Gernot, Shaw, Andrew D., Lakhmir S Chawla, Rimmelé, Thomas, Antonio Artigas, Bihorac, Azra, Vincent, Jean-Louis, Laskowitz, Daniel T., Wilkerson, R Gentry, Walker, Michael G, Max Bell, Mullaney, Scott, Amy M Sprague, McCullough, Peter A, Michael Joannidis, Gunnerson, Kyle J, Cely, Cynthia M., Shapiro, Nathan I, Thorsten Feldkamp, Marlies Ostermann, Gong, Michelle Ng, Lui G Forni, Kianoush Kashani, Lissauer, Matthew E., Chawla, Lakhmir S   +102 more
core   +1 more source

Emerging Blood-Based Biomarkers for Predicting Immunotherapy Response in NSCLC

, 2022
SIMPLE SUMMARY: Treatment with immunotherapy has been established as a standard treatment for lung cancer in recent years. Unfortunately, still, only a small proportion of patients benefit from the treatment, being the first leading cause of cancer death
Fonseca, Pablo, Oitabén, Ana, García-Benito, Carme, Juaneda-Magdalena, Laura, Carme García-Benito, Ana Oitabén, Clara González-Ojea, Martín E. Lázaro, Martínez-Fernández, Mónica, Lázaro, Martín E., Pablo Fonseca, Laura Juaneda-Magdalena, María J. Villanueva, Alberto Garrido-Fernández, López-López, Aida, González-Ojea, Clara, Mónica Martínez-Fernández, Aida López-López, Garrido-Fernández, Alberto, Villanueva, María J.   +19 more
core   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Sprifermin (rhFGF18) modulates extracellular matrix turnover in cartilage explants ex vivo

Journal of Translational Medicine, 2017
Background Sprifermin (recombinant human fibroblast growth factor 18) is in clinical development as a potential disease-modifying osteoarthritis drug (DMOAD).
Ditte Reker, Cecilie F. Kjelgaard-Petersen, Anne Sofie Siebuhr, Martin Michaelis, Anne Gigout, Morten A. Karsdal, Christoph Ladel, Anne C. Bay-Jensen   +7 more
doaj   +1 more source

Serum-Exosome-Derived miRNAs Serve as Promising Biomarkers for HCC Diagnosis

, 2022
Background: Serum exosomes are emerging as key liquid biopsy biomarkers for the early diagnosis of cancer. However, the proportion and distribution of small RNA (sRNA) species from serum exosomes of hepatocellular carcinoma (HCC) patients remain unclear.
Ning Tang, Tao Rui, Jufeng Guo, Zonglei Mao, Xiaobing Zhang, Jian Liu, Aizhai Xiang   +6 more
core   +1 more source