Results 81 to 90 of about 2,058,753 (356)

First exploration of the on-treatment changes in tumor and organ uptake of a radiolabeled anti PD-L1 antibody during chemoradiotherapy in patients with non-small cell lung cancer using whole body PET

Journal for ImmunoTherapy of Cancer
Background In patients with locally advanced unresectable non-small cell lung cancer (NSCLC), durvalumab, an anti-programmed cell death ligand-1 (PD-L1) antibody, has shown improved overall survival when used as consolidation therapy following concurrent
Tanja D de Gruijl, Teodora Radonic, Marc C Huisman, Idris Bahce, Johanna E E Pouw, Sayed M S Hashemi, Jessica E Wijngaarden, Maarten Slebe, Daniela E Oprea-Lager, Gerben J C Zwezerijnen, Danielle Vugts, Ezgi B Ulas, Suresh Senan, C Willemien Menke-van der Houven van Oordt   +13 more
doaj   +1 more source

Vitamin D Receptor Gene Polymorphisms Modify Cardiometabolic Response to Vitamin D Supplementation in T2DM Patients

Scientific Reports, 2017
There is conflicting evidence on the favorable effects of vitamin D supplementation on metabolic profile in Type 2 diabetes mellitus (T2DM) patients and this might be due to genetic variations in vitamin D receptors (VDRs). Thus, we studied the metabolic
Nasser M. Al-Daghri, Abdul Khader Mohammed, Omar S. Al-Attas, Mohammed Ghouse Ahmed Ansari, Kaiser Wani, Syed D. Hussain, Shaun Sabico, Gyanendra Tripathi, Majed S. Alokail   +8 more
doaj   +1 more source

Extracellular matrix remodeling proteins as biomarkers for clinical assessment and treatment outcomes in eosinophilic esophagitis

BMC Gastroenterology, 2023
Background Eosinophilic esophagitis (EoE) is a chronic progressive inflammatory disease of the esophagus, characterized by extracellular matrix remodeling and fibrotic stricture formation.
Martin Pehrsson, Willemijn E. de Rooij, Anne-Christine Bay-Jensen, Morten Asser Karsdal, Joachim Høg Mortensen, Albert Jan Bredenoord   +5 more
doaj   +1 more source

Wavelet feature extraction and genetic algorithm for biomarker detection in colorectal cancer data [PDF]

, 2012
Biomarkers which predict patient’s survival can play an important role in medical diagnosis and treatment. How to select the significant biomarkers from hundreds of protein markers is a key step in survival analysis.
Aickelin, Uwe, Durrant, Lindy G, Feyereisl, Jan, Liu, Yihui   +3 more
core   +3 more sources

MET variants with activating N‐lobe mutations identified in hereditary papillary renal cell carcinomas still require ligand stimulation

Molecular Oncology, EarlyView.
MET variants in the N‐lobe of the kinase domain, found in hereditary papillary renal cell carcinoma, require ligand stimulation to promote cell transformation, in contrast to other RTK variants. This suggests that HGF expression in the microenvironment is important for tumor growth in such patients. Their sensitivity to MET inhibitors opens the way for
Célia Guérin, Audrey Vinchent, Marie Fernandes, Isabelle Damour, Agathe Laratte, Rémi Tellier, Gabriella O. Estevam, Jean‐Pascal Meneboo, Céline Villenet, Clotilde Descarpentries, James S. Fraser, Martin Figeac, Alexis B. Cortot, Etienne Rouleau, David Tulasne   +14 more
wiley   +1 more source

Biomarkers of dissociation

BJPsych Open, 2023
Summary Dissociative symptoms present transdiagnostically and are related to poor clinical outcome. Research into the biological correlates of dissociation remains limited. This editorial summarises and discusses papers from this themed series of BJPsych Open that contribute to unravelling the biological correlates of dissociative symptomatology ...
Antje A. T. S. Reinders, Allan H. Young, Dick J. Veltman   +2 more
openaire   +4 more sources

Exploiting a new strategy to induce immunogenic cell death to improve dendritic cell-based vaccines for lymphoma immunotherapy

OncoImmunology, 2017
Although promising, the clinical benefit provided by dendritic cell (DC)-based vaccines is still limited and the choice of the optimal antigen formulation is still an unresolved issue.
B. Montico, C. Lapenta, M. Ravo, D. Martorelli, E. Muraro, B. Zeng, E. Comaro, M. Spada, S. Donati, S. M. Santini, R. Tarallo, G. Giurato, F. Rizzo, A. Weisz, F. Belardelli, R. Dolcetti, J. Dal Col   +16 more
doaj   +1 more source

Serum Metabolic Alterations upon Zika Infection

Frontiers in Microbiology, 2017
Zika virus (ZIKV) infection has recently emerged as a major concern worldwide due to its strong association with nervous system malformation (microcephaly) of fetuses in pregnant women infected by the virus. Signs and symptoms of ZIKV infection are often
Carlos Fernando O. R. Melo, Jeany Delafiori, Diogo N. de Oliveira, Tatiane M. Guerreiro, Cibele Z. Esteves, Estela de O. Lima, Victoria Pando-Robles, Rodrigo R. Catharino, the Zika-Unicamp Network, Guilherme P. Milanez, Gabriela M. do Nascimento, André R. R. Freitas, Rodrigo Angerami, Fábio T. Maranhão Costa, Clarice W. Arns, Mariangela R. Resende, Eliana Amaral, Renato P. Junior, Carolina C. Ribeiro-do-Valle, Helaine Milanez, Maria L. Moretti, Jose L. Proenca-Modena, Glaucia M. Pastore, Kleber Y. Fertrin, Márcia T. Garcia, Roseli Calil, João R. B. Júnior, Giuliane J. Lajos, Maria L. Costa, Marcos T. N. da Silva, Albina Altemani, Ana C. Coan, Maria F. Colella-Santos, Andrea P. B. von Zuben, Marco A. R. Vinolo, Rosemeire F. de O. de Paula, Carla C. Judice, Juliana A. Leite, Leonardo C. Caserta, Ana P. de Moraes, Ana C. S. Barnabé, Ana L. R. da Soledade, Daniel A. T. Teixeira, Évellyn R. de Morais, Felipe R. Santos   +44 more
doaj   +1 more source

Prognostic importance of emerging cardiac, inflammatory, and renal biomarkers in chronic heart failure patients with reduced ejection fraction and anaemia: RED-HF study [PDF]

, 2018
Aims: To test the prognostic value of emerging biomarkers in the Reduction of Events by Darbepoetin Alfa in Heart Failure (RED-HF) trial. Methods and results: Circulating cardiac [N-terminal pro-B-type natriuretic peptide (NT-proBNP), and high ...
Alehagen, Arimoto, Balling, Bolignano, Cabassi, Dupont, Gaggin, Gravning, Grodin, Guisado Espartero, Haehling, Harrell, Jackson, Lassus, Lassus, Lok, Maisel, Maisel, McMurray, McMurray, Miller, Miller, Nagarajan, Park, Pascual-Figal, Pencina, Pencina, Pocock, Ponikowski, Rahimi, Rush, Shlipak, Swedberg, Tentzeris, Zamora   +34 more
core   +4 more sources

Response to neoadjuvant chemotherapy in early breast cancers is associated with epithelial–mesenchymal transition and tumor‐infiltrating lymphocytes

Molecular Oncology, EarlyView.
Epithelial–mesenchymal transition (EMT) and tumor‐infiltrating lymphocytes (TILs) are associated with early breast cancer response to neoadjuvant chemotherapy (NAC). This study evaluated EMT and TIL shifts, with immunofluorescence and RNA sequencing, at diagnosis and in residual tumors as potential biomarkers associated with treatment response.
Françoise Derouane, Jérôme Ambroise, Cédric van Marcke, Mieke Van Bockstal, Martine Berlière, Christine Galant, Hélène Dano, Médina Lougué, Elena Benidovskaya, Guy Jerusalem, Vincent Bours, Claire Josse, Jérôme Thiry, Aurélie Daumerie, Caroline Bouzin, Cyril Corbet, François P. Duhoux   +16 more
wiley   +1 more source