Results 81 to 90 of about 163,714 (297)

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Bioactivity enhancement by Sr doped Zn-Ca-P coatings on biomedical magnesium alloy

Journal of Magnesium and Alloys, 2019
The effect of strontium doped Zn-Ca-P (ZCP) coating by chemical conversion technique on the biodegradation of AZ31 alloy was evaluated. The coating formed with 1.5 wt.% Sr and 20 min phosphating time at 50 °C with pH 2.5 completely covers the alloy ...
P. Amaravathy, T.S. Sampath Kumar
doaj   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Automated analysis of atrial late gadolinium enhancement imaging that correlates with endocardial voltage and clinical outcomes: A 2-center study [PDF]

, 2013
This work was supported by the British Heart Foundation PG/10/37/28347, RG/10/11/28457, NIHR Biomedical Research Centre funding, and the ElectroCardioMaths Programme of the Imperial BHF Centre of Research ...
Peters, NS, Petersen, SE, Kojodjojo, P., Quest, R, Hunter, R., Petersen, S.E., Karim, R, Quest, R., Lim, PB, Ariff, B., Francis, D.P., Malcolme-Lawes, L.C., Kanagaratnam, P., Juli, C., Schilling, R, Karim, R., Boubertakh, R., Schilling, R., Bai, W, Lim, P.B., Francis, DP, Jamil-Copley, S., Peters, N.S., Rueckert, D, Kanagaratnam, P, Bai, W., Malcolme-Lawes, LC, Davies, D.W., Davies, DW, Boubertakh, R, Jones, D., Juli, C, Kojodjojo, P, Hunter, R, Rueckert, D., Jamil-Copley, S, Ariff, B, Jones, D   +37 more
core   +1 more source

Moral Perfection and the Demand for Human Enhancement

Ethics in Progress, 2015
In this article I discuss one of the most significant areas of bioethical interest, which is the problem of moral enhancement. Since I claim that the crucial issue in the current debate on human bioenhancement is the problem of agency, I bring out and ...
Adriana Warmbier
doaj   +3 more sources

Experimental test of the entanglement enhancement in two-photon fluorescence

Quantum Frontiers
Entangled photons with time-energy correlations are predicted to have improved sensitivity compared with classical light in two-photon fluorescence, which is promising for lowering the phototoxicity in biomedical imaging.
Gewei Qian, Xiao Liu, Chenran Xu, Xingqi Xu, Da-Wei Wang   +4 more
doaj   +1 more source

The skills required for transition to university and study in biological sciences: A student perspective

FEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source

Biofeedback - March 2016 [PDF]

, 2016
Archived record for the USA Biomedical Library newsletter for March 2016. Content includes: Director\u27s Notes: New Faces in the Library Biomedical Library Subscribes to UpToDate Staff Spotlight: Ron Edmonson Library Technical Assistant Meet Rachel ...
Staff, Biomedical Library
core   +1 more source

Why human connection is the true metric of research success

FEBS Open Bio, EarlyView.
Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan, Mattias Wei Ren Kon, Xavier Coumoul, Fun Man Fung   +3 more
wiley   +1 more source