Results 51 to 60 of about 1,329,782 (302)

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Inflammatory targeted nanoplatform incorporated with antioxidative nano iron oxide to attenuate ulcerative colitis progression

iScience
Summary: Antioxidative nanomaterials with reactive oxygen species (ROS) scavenging capabilities hold promise for the treatment of ulcerative colitis (UC).
Haojun Chen, Wei Sun, Can Li, Qiuyang Wang, Xucai Wang, Yingjie Du, Wenbo Chen, Min Wang, Caoxing Huang, Rong Wang   +9 more
doaj   +1 more source

Mesoporous silica nanoparticles prepared by different methods for biomedical applications: Comparative study

IET Nanobiotechnology, 2021
In the current investigation, mesoporous silica nanoparticles were obtained by various techniques, namely sol–gel (S1), micro‐emulsion (S2) and hydrothermal synthesis (S3).
Mohamed M. Ashour, Mostafa Mabrouk, Islam E. Soliman, Hanan H. Beherei, Khairy M. Tohamy   +4 more
doaj   +1 more source

In Diamond Health [PDF]

, 2008
In contrast to the sparkling gemstone, diamond-like carbon (DLC) is a thin film coating that is dense, inert, low friction and hard wearing. Interdisciplinary research, involving materials scientists, physicists, mechanical engineers, biomedical ...
Anson, AW, Jones, BJ
core  

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Liposome nano‐formulation with cationic polar lipid DOTAP and cholesterol as a suitable pH‐responsive carrier for molecular therapeutic drug (all‐trans retinoic acid) delivery to lung cancer cells

IET Nanobiotechnology, 2021
The molecular targeted drug ATRA demands a suitable carrier that delivers to the cancer site due to its poor bioavailability and drug resistance. ATRA, being a lipid with carboxylic acid, has been nano‐formulated as a cationic lipo‐ATRA with DOTAP ...
Viswanathan Mariammal Berlin Grace, Devarajan David Wilson, Chandrasekharan Guruvayoorappan, Jesubatham Perinba Danisha, Lucia Bonati   +4 more
doaj   +1 more source

Effect of Galvanic Corrosion on the Degradability of Biomedical Magnesium

Frontiers in Materials, 2021
With recent progress in clinical trials and scale-up applications of biodegradable magnesium-based implants, the scenarios of transplanting biodegradable Mg with other non-degradable metals may occur inevitably.
Hongzhou Peng, Wei Wang, Haomiao Jiang, Rui Zan, Yu Sun, Song Yu, Jiahua Ni, Wenhui Wang, Tao Wang, Jian Wang, Xiaonong Zhang, Xiaonong Zhang   +11 more
doaj   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Enhanced antibacterial activity and superior biocompatibility of cobalt-deposited titanium discs for possible use in implant dentistry

iScience
Summary: The clinical success of implants depends on rapid osseointegration, and new materials are being developed considering the increasing demand. Considering cobalt (Co) antibacterial characteristics, we developed Co-deposited titanium (Ti) using ...
Vaibhav Madiwal, Bhushan Khairnar, Jyutika Rajwade   +2 more
doaj   +1 more source

Recent advances in surface-functionalised photosensitive antibacterials with synergistic effects

Biosurface and Biotribology, 2019
The alarm has been ringing over the gradually increasing drug-resistant bacteria, which calls for the development of safer antibacterial materials. Photosensitive antibacterials are considered as a promising alternative solution due to their unique light-
Peizi Liao, Jiahao Hu, Huagao Wang, Jinyang Li, Zuowan Zhou, Zuowan Zhou   +5 more
doaj   +1 more source