Results 61 to 70 of about 6,291,828 (301)

Amount of TNF-α released from macrophages reacting with polyethylene particles showed dose-dependent relationship to the total surface area of added particles

Biosurface and Biotribology, 2018
The immune response to ultra-high molecular weight polyethylene wear debris is thought to be one of the major causes of osteolysis and aseptic loosening.
Weiqi Shen, Naohide Tomita, Miho Niikura, Takuma Sugino   +3 more
doaj   +1 more source

Improved corrosion resistance and biocompatibility of biomedical magnesium alloy with polypeptide TK14 functionalised hydrophobic coating

Biosurface and Biotribology, 2021
Magnesium (Mg) and its alloys can be used as biomedical materials because of their excellent mechanical properties and biocompatibility. However, the rapid degradation rate of Mg‐based materials limits their application in biodegradable intravascular ...
Yang Shen, Xiaolong Shen, Hao Zhang, Xin Li, Tengda Shang, Yuancong Zhao, Jin Wang, Nan Huang   +7 more
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Seawater-contaminated ulnar rabbit bone defects repair using 3D-printed β-TCP/vancomycin composite scaffolds

European Cells & Materials
Background: Repairing extensive bone defects following seawater immersion poses a significant challenge for orthopedic surgeons. Recent advancements in three-dimensional (3D) printing technology have demonstrated considerable potential in fabricating ...
HD Lao, D Liu, R Yi, YN Yuan, M Zhao, GS Li, XY Nie, JL Gu, XM Cai, H Li, SE Lin, JJ Zhou   +11 more
doaj   +1 more source

Flexible, high‐strength titanium nanowire for scaffold biomimetic periodontal membrane

Biosurface and Biotribology, 2021
A layer of micro‐sized periodontal membrane can buffer most chewing forces to protect the interface between the natural tooth root and alveolar bone. Artificial dental implants usually direct contact onto the alveolar bone without a buffer layer, which ...
Jin Li, Licheng Hua, Weiyuan Wang, Chenjie Gu, Jianke Du, Conghu Hu   +5 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

BIOMEDICAL MATERIALS BASED ON FULLERENES

Scientific Study & Research: Chemistry & Chemical Engineering, Biotechnology, Food Industry, 2011
Fullerenic soluble derivatives are essential for many biomedical techniques that exploit the chemical and physical properties of these unique structural carbon nanospheres.
Radu Claudiu Fierascu, Irina Dumitriu, Rodica Mariana Ion, Raluca Ioana Bunghez, Monica Neagu, Carolina Constantin, Crina Stavaru   +6 more
doaj  

G-quartet driven adaptive hydrogels that integrate constitutional dynamics for antibacterial action and tissue repair

iScience
Summary: We report a nucleic acid inspired constitutional dynamic hydrogel (G4TZ) self-assembled from guanosine, a phenylboronic acid, and a thiazole peptide through dynamic covalent linkages formed by boronate ester and imine bonds, together with ...
Sudeshna Mondal, Binayak Lala, Debasmita Biswas, Jean Marie Lehn, Jyotirmayee Dash   +4 more
doaj   +1 more source

Copper‐mediated polyurethane materials with enzyme‐like catalysis for biocompatibility improvement in blood environments

Biosurface and Biotribology, 2021
Because of their good performance, including biocompatibility and mechanical properties, polyurethanes (PUs) are widely used in medical devices. However, undesired compatibility troubles, including thrombus, inflammation, and hyperplasia, still limit the
Jiaxin Dou, Peichuang Li, Yuancong Zhao, Lei Zhou, Xin Li, Jin Wang, Nan Huang   +6 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source