Results 41 to 50 of about 1,215,832 (310)

The Panopticon and the performance arena: HCI reaches within [PDF]

open access: yes, 2009
The impact of new technologies is hard to predict. We suggest the value of theories of performativity in understanding dynamics around the convergence of biomedical and information technology.
Light, Ann, Wright, P.
core   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

open access: yesMolecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Southwest Research Institute assistance to NASA in biomedical areas of the Technology Utilization program [PDF]

open access: yes
Technology utilization in biomedical areas, particularly for infants and handicapped ...
Culclasure, D. F., Eckhardt, L.
core   +4 more sources

Sociology of low expectations: Recalibration as innovation work in biomedicine [PDF]

open access: yes, 2015
"This article is distributed under the terms of the Creative Commons Attribution 3.0 License (http://www.creativecommons.org/licenses/by/3.0/) which permits any use, reproduction and distribution of the work without further permission provided the ...
Brown Nik   +11 more
core   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

open access: yesMolecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon   +4 more
wiley   +1 more source

Challenges for health systems in Member Countries of the Organisation for Economic Co-operation and Development

open access: yesBulletin of the World Health Organization, 2000
For reasons of equity most OECD countries have chosen to base their funding of health care mainly on public sources. There is an almost universal problem of affordability in the health systems of these countries, arising from the tension between the ...
Jeremy Hurst
doaj  

The Use of Health Technology to Enhance the Adherence of Tuberculosis Treatment: A Systematic Review

open access: yesJurnal Ners, 2019
Introduction: Disobedience in the context of TB treatment is one of the major problems around the world. Many efforts have been made to improve the adherence to TB treatment; one of them is the utilization of health technology such as digital technology.
Dwi Uswatun Sholikhah   +4 more
doaj   +1 more source

Non-Contact Video-Based Neonatal Respiratory Monitoring

open access: yesChildren, 2020
Respiratory rate (RR) has been shown to be a reliable predictor of cardio-pulmonary deterioration, but standard RR monitoring methods in the neonatal intensive care units (NICU) with contact leads have been related to iatrogenic complications.
Scott L. Rossol   +6 more
doaj   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

open access: yesMolecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

open access: yesMolecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley   +5 more
wiley   +1 more source

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