Results 1 to 10 of about 3,817 (117)

Mapeamento das preferências de atores estratégicos sobre os critérios de priorização para o monitoramento do horizonte tecnológico em saúde

Cadernos de Saúde Pública
Resumo: Entre as etapas básicas de um sistema de monitoramento do horizonte de tecnologias emergentes, estão a filtragem e a priorização dessas tecnologias. Este trabalho tem por objetivo mapear as preferências dos atores estratégicos do Sistema Único de
Aline do Nascimento, Avila Teixeira Vidal, Rosimary Terezinha de Almeida   +2 more
doaj   +1 more source

Phase IIB, Randomized, Double‐Blind, Placebo‐Controlled Clinical Trial of Intravenous Defibrotide for the Prevention and Treatment of Respiratory Distress and Cytokine Release Syndrome in COVID‐19

European Journal of Haematology, EarlyView.
ABSTRACT Introduction Endothelial dysfunction is key in COVID‐19 pathogenesis. This randomized, double‐blind phase IIb trial investigated continuous intravenous infusion of defibrotide in patients hospitalized with SARS‐CoV‐2 infection and respiratory failure.
Ruben Jara Rubio, Antonio José Martinez‐Mellado, Jonathan Kiwitt‐Cárdenas, José G. Clavel, Bartolomé García‐Perez, Pedro Castro, Maribel Diaz‐Ricart, Andrés Carrillo‐Alcaraz, Amparo López‐Bernús, Enrique Bernal Morell, Aychel Roura, Sonia Marín, Francisco‐José Ruiz‐López, Elena Solana‐Martinez, Domingo Martinez‐Baño, Carlos L. Albacete Moreno, Enriqueta Andreu Soler, Adrián Tellez Santoyo, Sara Fernández Méndez, Jose A. Noguera Velasco, Iria Cebreiros Lopez, Andrés Parrilla, Alberto Espuny‐Miró, David García‐Bernal, Miguel Blanquer, Andrés Sánchez‐Salinas, Francisca Iniesta, Cristina Hernandez Garcia, Manuel Muro, Alfredo Minguela Puras, Antonio Moreno‐Docón, Alberto M. Torres‐Cantero, Maria Munoz Garcia, Manuel Serrano, Massimo Iacobelli, Carmelo Carlo‐Stella, Lee‐Jen Wei, Paul G. Richardson, José M. Moraleda   +38 more
wiley   +1 more source

Chd4 and ThPOK cooperate to preserve structural and electrophysiological integrity of the adult heart through Sprr1a repression

The FEBS Journal, EarlyView.
Chd4/NuRD and ThPOK cooperate to maintain transcriptional repression and nuclear organization in adult cardiomyocytes. Chd4 loss reduces miR‐150‐5p, relieving repression of Sprr1a, while ThPOK loss further enhances Sprr1a activation, possibly through altered chromatin–lamina interactions.
Fadoua El Abdellaoui‐Soussi, Apolonia Novillo, Rocío Brea, Marta Ysbert, Lorena Cussó, Gonzalo Pizarro‐Sánchez, Manuel Desco, Iván Hernández, Ángel Luis Armesilla, Ignacio Pérez de Castro, Alicia R. Folgueras, Juan Miguel Redondo, Pablo Gómez‐del Arco   +12 more
wiley   +1 more source

Effects of repeated exposure to ozonated water on hair fibre structure and integrity: Part I

International Journal of Cosmetic Science, EarlyView.
Repeated exposure to ozonated water caused cumulative oxidative changes in hair, altering structural integrity, thermal behaviour and mechanical properties. The findings reveal a distinct ozone‐induced damage profile that progresses beyond the cuticle, challenging claims of hair‐revitalizing benefits. Abstract Objective Ozone has recently been marketed
Pedro Augusto Laurindo Igreja Marrafa, Shamish Ganpule, Vanessa Castro‐Haly, Adriana Barrinha Fernandes, Ernesta Malinauskyte, Carlos Jose de Lima   +5 more
wiley   +1 more source

6‐Month Clinical Evaluation of Reduced Dentin Etching Time Using Universal Adhesives in Noncarious Cervical Lesions: A Double‐Blind Randomized Clinical Trial

Journal of Esthetic and Restorative Dentistry, EarlyView.
ABSTRACT Objectives To evaluate the effect of reduced dentin etching time on the clinical performance of two universal adhesive systems in noncarious cervical lesions (NCCLs). Methods A total of 144 NCCLs restorations were randomly placed in 36 participants according to four experimental groups: SUP5 (Scotchbond Universal Plus adhesive [pH ≈2.5–2.7 ...
Mario Felipe Gutiérrez, Natalia Amo‐Nicolás, Alondra Beniscelli‐Vásquez, Romina Aliaga‐Gálvez, Alessandro D. Loguercio   +4 more
wiley   +1 more source

SIMUNEO: Control and Monitoring System for Lung Ultrasound Examination and Treatment of Neonatal Pneumothorax and Thoracic Effusion

Sensors, 2023
Training with real patients is a critical aspect of the learning and growth of doctors in training. However, this essential step in the educational process for clinicians can potentially compromise patient safety, as they may not be adequately prepared ...
Adriana Rojas-García, Diego Moreno-Blanco, Martin Otero-Arteseros, Francisco Javier Rubio-Bolívar, Helena Peinado, Dolores Elorza-Fernández, Enrique J. Gómez, Manuel Quintana-Díaz, Patricia Sánchez-Gonzalez   +8 more
doaj   +1 more source

Physiological and Sleep Profiles in Insomnia, OSA and COMISA: A Comparative Study in Portugal and Spain

Journal of Sleep Research, EarlyView.
ABSTRACT Insomnia and obstructive sleep apnea (OSA) are common sleep disorders that often co‐occur as comorbid insomnia and sleep apnea (COMISA), worsening health outcomes. This study characterized and compared the physiological and sleep profiles of insomnia, OSA and COMISA in population‐based datasets from Portugal (n = 147) and Spain (n = 264 ...
Margarida Carvalho, Eva Almeida, Pedro Amorim, Marta Drummond, Adrián Martín‐Montero, Gonzalo C. Gutiérrez‐Tobal, Tomás Ruiz‐Albi, Julio De Frutos, Pedro Pereira Rodrigues, Daniela Ferreira‐Santos   +9 more
wiley   +1 more source

Emotional salience modulates the forward-flow of memory

Royal Society Open Science
As we navigate our day-to-day lives, we regularly adapt our behaviour according to what we predict may happen next in a given context. When an unexpected event occurs, our predictions about the world are disrupted and must be updated.
Alba Peris-Yague, Darya Frank, Robin Hellerstedt, Bryan A. Strange   +3 more
doaj   +1 more source

VALIDAÇÃO DE CONTEÚDO DE UMA TECNOLOGIA EDUCACIONAL SOBRE SAÚDE DO HOMEM

Revista Baiana de Enfermagem, 2020
Objetivo: validar o conteúdo da tecnologia educacional “Saúde do Homem: dicas para uma vida saudável”. Método: trata-se de estudo metodológico de validação de conteúdo com juízes especialistas. Aplicou-se um questionário validado que utiliza a escala do
Darlisom Sousa Ferreira, Elizabeth Teixeira, Daniel Oliveira Brown, Rodrigo Koch, Wagner Ferreira Monteiro, Edinilza Ribeiro dos Santos, Marília Muniz Cavalcante de Oliveira   +6 more
doaj   +1 more source

Cannabinoid and adenosine A2A receptor crosstalk regulates postnatal and adult hippocampal neurogenesis

British Journal of Pharmacology, Volume 183, Issue 18, Page 5440-5457, September 2026.
Background and purpose Adult neurogenesis is a tightly regulated process affected by both cannabinoid receptors (CB1 and CB2) and adenosine 2A (A2A) receptors, both of which modulate neural progenitor cell activity. While emerging evidence suggests an interaction between these neuromodulatory systems, the extent and mechanism of their interplay in ...
Rui S. Rodrigues, Adam Armada‐Moreira, Laura Gómez‐Acero, Filipa F. Ribeiro, Francisco M. Mouro, Ana M. Sebastião, Francisco Ciruela, Ester Aso, Sara Xapelli   +8 more
wiley   +1 more source