Results 41 to 50 of about 5,700 (167)

Schedule‐dependent neuroprotection by pioglitazone in a novel model of α‐synucleinopathy in rats: Integrated behavioural and histological outcomes

British Journal of Pharmacology, EarlyView.
Background and Purpose α‐Synucleinopathies are neurodegenerative disorders characterized by the aggregation and propagation of misfolded α‐synuclein. In Parkinson's disease (PD), the most common α‐synucleinopathy, the progression of motor and nonmotor deficits, and dopaminergic neuron loss, are closely linked to the spreading of misfolded α‐synuclein ...
Alberto Santiago‐Balmaseda, Marcos M. Villegas‐Rojas, Isaac Pérez‐Segura, Maricela Espino‐Cambrón, Daniel Martinez‐Fong, Luis O. Soto‐Rojas   +5 more
wiley   +1 more source

Protein sequence analysis in the context of drug repurposing

BMC Medical Informatics and Decision Making
Motivation Drug repurposing speeds up the development of new treatments, being less costly, risky, and time consuming than de novo drug discovery. There are numerous biological elements that contribute to the development of diseases and, as a result, to ...
Natalia García Sánchez, Esther Ugarte Carro, Lucía Prieto-Santamaría, Alejandro Rodríguez-González   +3 more
doaj   +1 more source

Integrating Speculation Detection and Deep Learning to Extract Lung Cancer Diagnosis from Clinical Notes

Applied Sciences, 2021
Despite efforts to develop models for extracting medical concepts from clinical notes, there are still some challenges in particular to be able to relate concepts to dates.
Oswaldo Solarte Pabón, Maria Torrente, Mariano Provencio, Alejandro Rodríguez-Gonzalez, Ernestina Menasalvas   +4 more
doaj   +1 more source

Cannabinoid and adenosine A2A receptor crosstalk regulates postnatal and adult hippocampal neurogenesis

British Journal of Pharmacology, EarlyView.
Background and purpose Adult neurogenesis is a tightly regulated process affected by both cannabinoid receptors (CB1 and CB2) and adenosine 2A (A2A) receptors, both of which modulate neural progenitor cell activity. While emerging evidence suggests an interaction between these neuromodulatory systems, the extent and mechanism of their interplay in ...
Rui S. Rodrigues, Adam Armada‐Moreira, Laura Gómez‐Acero, Filipa F. Ribeiro, Francisco M. Mouro, Ana M. Sebastião, Francisco Ciruela, Ester Aso, Sara Xapelli   +8 more
wiley   +1 more source

Diseño de una estrategia para dar a conocer de una forma práctica y concisa, la información sobre la tecnología biomédica a paciente y familiares dando cumplimiento a la ley 100 en sus artículos 186 y 227, basado la Resolución 5095 del 19 de noviembre del 2018

, 2023
RESUMEN : Como parte del proceso de acreditación, los centros asistenciales, incluidas clínicas y hospitales, deben cumplir con los estándares estipulados en el Manual de Acreditación en Salud Ambulatorio y Hospitalario en Colombia en su versión 3.1.
Marín Franco, María Camila
core  

Actualización del proceso de obsolescencia de la tecnología Biomédica del Instituto para Niños Ciegos y Sordos en sus sedes Cali, Buenaventura y Palmira [PDF]

, 2021
El presente trabajo de grado consistió en realizar la actualización del proceso de obsolescencia del Instituto para Niños Ciegos y Sordos (INCS) en sus sedes de Cali, Buenaventura y Palmira.
Castillo Landázuri, Urso Jair, Torres Nagles, Cesar Camilo   +1 more
core   +1 more source

Identifying patterns to uncover the importance of biological pathways on known drug repurposing scenarios

BMC Genomics
Background Drug repurposing plays a significant role in providing effective treatments for certain diseases faster and more cost-effectively. Successful repurposing cases are mostly supported by a classical paradigm that stems from de novo drug ...
Belén Otero-Carrasco, Esther Ugarte Carro, Lucía Prieto-Santamaría, Marina Diaz Uzquiano, Juan Pedro Caraça-Valente Hernández, Alejandro Rodríguez-González   +5 more
doaj   +1 more source

Frequência escolar em indivíduos com paralisia cerebral no Brasil

Developmental Medicine &Child Neurology, EarlyView.
Objetivo Identificar fatores associados à frequência escolar entre crianças, adolescentes e jovens adultos brasileiros com paralisia cerebral (PC), utilizando dados populacionais do Registro Brasileiro de Paralisia Cerebral (RBPC). Método Este estudo transversal analisou dados de 774 indivíduos com PC, com idades entre 4 e 21 anos, registrados no RPBC.
Ricardo Rodrigues de Sousa Junior, Luana Cristina da Silva, Ana Cristina Resende Camargos, Eliane Beatriz Cunha Policiano, Lívia Ferreira Coutinho Alonso, Nadia Badawi, Israt Jahan, Gulam Khandaker, Maria De Las Mercedes Ruiz Brunner, Paula Silva de Carvalho Chagas, Hércules Ribeiro Leite   +10 more
wiley   +1 more source

Phase IIB, Randomized, Double‐Blind, Placebo‐Controlled Clinical Trial of Intravenous Defibrotide for the Prevention and Treatment of Respiratory Distress and Cytokine Release Syndrome in COVID‐19

European Journal of Haematology, EarlyView.
ABSTRACT Introduction Endothelial dysfunction is key in COVID‐19 pathogenesis. This randomized, double‐blind phase IIb trial investigated continuous intravenous infusion of defibrotide in patients hospitalized with SARS‐CoV‐2 infection and respiratory failure.
Ruben Jara Rubio, Antonio José Martinez‐Mellado, Jonathan Kiwitt‐Cárdenas, José G. Clavel, Bartolomé García‐Perez, Pedro Castro, Maribel Diaz‐Ricart, Andrés Carrillo‐Alcaraz, Amparo López‐Bernús, Enrique Bernal Morell, Aychel Roura, Sonia Marín, Francisco‐José Ruiz‐López, Elena Solana‐Martinez, Domingo Martinez‐Baño, Carlos L. Albacete Moreno, Enriqueta Andreu Soler, Adrián Tellez Santoyo, Sara Fernández Méndez, Jose A. Noguera Velasco, Iria Cebreiros Lopez, Andrés Parrilla, Alberto Espuny‐Miró, David García‐Bernal, Miguel Blanquer, Andrés Sánchez‐Salinas, Francisca Iniesta, Cristina Hernandez Garcia, Manuel Muro, Alfredo Minguela Puras, Antonio Moreno‐Docón, Alberto M. Torres‐Cantero, Maria Munoz Garcia, Manuel Serrano, Massimo Iacobelli, Carmelo Carlo‐Stella, Lee‐Jen Wei, Paul G. Richardson, José M. Moraleda   +38 more
wiley   +1 more source

Estandarización del proceso de adquisición y evaluación de nueva tecnología biomédica para la clínica CES con fines de acreditación [PDF]

, 2021
RESUMEN: La adquisición de la tecnología biomédica es el proceso mediante el cual se ejecuta la operación de compra-venta, comodato o donación de un equipo entre una institución y un proveedor, sin embargo, antes de realizar la incorporación de la ...
Cárdenas Chizabas, Dennys Lorena
core