Results 61 to 70 of about 559,312 (314)

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

open access: yesMolecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon   +4 more
wiley   +1 more source

Saúde e inovação: uma abordagem sistêmica das indústrias da saúde

open access: yesCadernos de Saúde Pública
Partindo do reconhecimento da importância da geração e da difusão de inovações para o desenvolvimento sócio-econômico nos países capitalistas e do caráter sistêmico, institucional e histórico desse processo, o trabalho procura evidenciar a necessidade de
Carlos Augusto Grabois Gadelha   +2 more
doaj  

Método simplificado versus convencional de confecção de próteses totais: práticas adotadas pelos Cirurgiões-Dentistas

open access: yesRevista de Odontologia da UNESP
Introdução: A fim de reduzir custos e tempo clínico envolvidos com o tratamento, Dentistas têm utilizado métodos simplificados, omitindo ou abreviando partes da técnica de confecção das próteses totais.
Thais Angelina Caetano   +4 more
doaj   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

open access: yesMolecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Aplicación académica de mensajes de texto en un curso de primeros auxilios: estudio piloto en una universidad privada de Lima, Perú

open access: yesRevista Peruana de Medicina Experimental y Salud Pública
El objetivo del estudio fue desarrollar y evaluar el impacto de una intervención educativa con el uso de mensajes de texto (SMS) en un curso de primeros auxilios. Se realizó un estudio prospectivo y de intervención.
Rodrigo M Carrillo-Larco   +2 more
doaj  

Health technology assessment. Evaluation of biomedical innovative technologies.

open access: yesIEEE engineering in medicine and biology magazine : the quarterly magazine of the Engineering in Medicine & Biology Society, 2010
This article describes health technology assessment (HTA) as an evaluation tool that applies systematic methods of inquiry to the generation and use of health technologies and new products. The focus of this article is on the contributions of HTA to the management of the new product development effort in the biomedical organization.
TURCHETTI, Giuseppe   +2 more
openaire   +2 more sources

Microfluidic electro‐viscoelastic manipulation of extracellular vesicles

open access: yesFEBS Open Bio, EarlyView.
The electro‐viscoelastic manipulation as a potential method for separation of particles based on size. The particles introduced as a sheath flow migrate to the channel center under the influence of simultaneously applied electric field and pressure driven flow.
Seyedamirhosein Abdorahimzadeh   +7 more
wiley   +1 more source

Biomedical technology, socioeconomics, and biomedical computing: implications for change

open access: yesCleveland Clinic Journal of Medicine, 1989
Pathology and laboratory medicine have changed rapidly since 1945. Three forces can be recognized as major vectors for change: rapid application of the biotechnology evolving from research in molecular biology, radically changing medical socioeconomics, and the evolving field of medical information science.
openaire   +2 more sources

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

open access: yesFEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini   +2 more
wiley   +1 more source

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