Results 41 to 50 of about 587,998 (265)

Opportunities for Artificial Intelligence in Operational Medicine: Lessons from the United States Military

Bioengineering
Conducted in challenging environments such as disaster or conflict areas, operational medicine presents unique challenges for the delivery of efficient and quality healthcare.
Nikolai Rakhilin, H. Douglas Morris, Dzung L. Pham, Maureen N. Hood, Vincent B. Ho   +4 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Feasibility of in-home monitoring for people with glaucoma: the I-TRAC mixed-methods study

Health Technology Assessment
Background Glaucoma is a chronic disease of the optic nerve and a leading cause of severe visual loss in the UK. Once patients have been diagnosed, they need regular monitoring at hospital eye services.
Carrie Stewart, Hangjian Wu, Uma Alagappan, Augusto Azuara-Blanco, Anthony J King, Andrew J Tatham, Rodolfo Hernández, Bruce Lowe, Darian Shotton, Nana Appiah, Taylor Coffey, Thenmalar Vadiveloo, Graeme MacLennan, Katie Gillies   +13 more
doaj   +1 more source

PedAMINES: a disruptive mHealth app to tackle paediatric medication errors

Swiss Medical Weekly, 2020
Medication errors are among the most common medical adverse events and an important cause of patient morbidity and mortality, affecting millions of people worldwide each year.
Frédéric Ehrler, Johan N. Siebert
doaj   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Nuevas tecnologías en el manejo de la demencia: una revisión de alcance

MedUNAB
RESUMEN Introducción. La demencia es un trastorno con una carga de morbimortalidad global importante. Las nuevas tecnologías son clave para los avances en salud.
Martínez-Torres, Liz Mariana, Mejía-Camacho, Sebastián Camilo, Chavarro-Carvajal, Diego Andrés, Santacruz-Escudero, José Manuel, Cano-Gutiérrez, Carlos Alberto   +4 more
doaj   +1 more source

Development of human monoclonal antibodies against TARM1 by yeast display

FEBS Open Bio, EarlyView.
Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe, Mayumi Saeki, Masaaki Hashiguchi, Sayaka Ono, Kazuhisa Aoki, Hidetaka Tanno   +5 more
wiley   +1 more source

The Impact of a Novel Immersive Virtual Reality Technology Associated with Serious Games in Parkinson’s Disease Patients on Upper Limb Rehabilitation: A Mixed Methods Intervention Study

Sensors, 2020
Background: Parkinson’s disease is a neurodegenerative disorder that causes impaired motor functions. Virtual reality technology may be recommended to optimize motor learning in a safe environment.
Patricia Sánchez-Herrera-Baeza, Roberto Cano-de-la-Cuerda, Edwin Daniel Oña-Simbaña, Domingo Palacios-Ceña, Jorge Pérez-Corrales, Juan Nicolas Cuenca-Zaldivar, Javier Gueita-Rodriguez, Carlos Balaguer-Bernaldo de Quirós, Alberto Jardón-Huete, Alicia Cuesta-Gomez   +9 more
doaj   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

A Review of Published Articles in the Field of Biomedical Nanotechnology in Medline Database during 2000-2010 [PDF]

Taṣvīr-i salāmat, 2012
Background and objectives : Nanotechnology is a new technology which is increasingly used over the past decade. Due to its great significance, governments are tending to invest greatly on the research and development on nanotechnology in various sectors ...
Peyman Sheikhzade
doaj