Results 51 to 60 of about 72,776 (216)

The cargo protein MAP17 (PDZK1IP1) regulates the cancer stem cell pool activating the Notch pathway by abducting NUMB [PDF]

, 2017
Purpose: Cancer stem cells (CSC) are self-renewing tumor cells, with the ability to generate diverse differentiated tumor cell subpopulations. They differ from normal stem cells in the deregulation of the mechanisms that normally control stem cell ...
Carnero Moya, Amancio, García Heredia, José Manuel, Lucena Cacace, Antonio, Pérez, Marco, Verdugo Sivianes, Eva María   +4 more
core   +1 more source

New Approach Methodologies (NAMs) in Alternative Methods: A Comparative Cytotoxicity Analysis of Nanostructured Hydroxyapatite in Adipose Stem Cells Spheroids

Journal of Applied Toxicology, EarlyView.
ABSTRACT Toxicological assessment is essential in NP approval for health and medical applications. Although 2D cell culture has been widely used, 3D models, especially spheroids, provide better predictive value for toxicological risk assessments since they replicate complex cellular interactions more accurately.
Bianca Montenegro, Rosângela Mayer Gonçalves, Marcelle Gomes Pegurier, Isabelle Amorim, Alexandre Malta Rossi, Leandra Santos Baptista   +5 more
wiley   +1 more source

Complementary and Integrative Medicine for the Treatment of Tourette's Syndrome

Movement Disorders Clinical Practice, EarlyView.
Abstract Background There is widespread interest in complementary and integrative medicine (CIM) among people with Tourette's syndrome (TS). Objective To perform a systematic review of evidence on the use of CIM to reduce tics and improve tic‐related quality of life.
Tamara Pringsheim, Catherine Deans, Saar Anis, Poonam Bhatia, Kevin Black, Yildiz Degirmenci, Donald Gilbert, Andreas Hartmann, Mariam Hull, Irene Malaty, Davide Martino, Alex Medina Escobar, Pablo Mir, Christelle Nilles, Marianna Sarchioto, Jibrin Sammani Usman, Harini Sarva, Katarzyna Smilowksa, Natalia Szejko, Kinga Tomczak, Daniel van Wamelen, Yulia Worbe   +21 more
wiley   +1 more source

Movimiento propulsado por reacciones químicas y mediante luz en partículas Janus y coloides activos

Revista de Química
A diferencia de los materiales inertes en equilibrio, la materia activa como los organismos biológicos se encuentran fuera del equilibrio generando movimiento y ensamblajes a partir de interacciones moleculares y reacciones químicas en la nano- y ...
Katherinne I. Requejo, Cristhian Cañari-Chumpitaz   +1 more
doaj   +1 more source

Evaluation of the anti-angiogenic potential of hydroxytyrosol derivatives [PDF]

, 2018
Angiogenesis, a process which allows the formation of new vessels from pre-existing ones, is an essential phenomenon for tumor survival since it allows cancer cells to obtain nutrients and oxygen.
Carrillo Fernández, Paloma, Castillo, Laura, Espartero, José L., Gallardo, Elena, Marrero, Ana Dácil, Martínez-Poveda, Beatriz, Medina, Miguel Ángel, Rodriguez-Quesada, Ana Maria   +7 more
core  

B-Raf and CRHR1 internalization mediate biphasic ERK1/2 activation by CRH in hippocampal HT22 Cells. [PDF]

, 2013
CRH is a key regulator of neuroendocrine, autonomic, and behavioral response to stress. CRH-stimulated CRH receptor 1 (CRHR1) activates ERK1/2 depending on intracellular context.
Arzt, Eduardo Simon, Bonfiglio, Juan José, Giacomini, Damiana Paula, Holsboer, Florian, Inda, Carolina, Maccarrone, Giuseppina, Refojo, Damian, Senin, Sergio Ariel, Silberstein Cuña, Susana Iris, Turck, Christoph W.   +9 more
core   +2 more sources

Titanium Detected in Liver, Kidney, Spleen, and Intestine Is Not Related to Dose, Time, or Route of Exposure to Titanium Dioxide: A Systematic Review

Environmental Toxicology, EarlyView.
ABSTRACT Titanium dioxide (TiO2), used as a food additive (labeled E171 in Europe), was withdrawn from the European market in 2022. The E171 toxicity mechanism involves its uptake, oxidative stress, DNA damage, and inflammation. It has been hypothesized that the TiO2 accumulation nanoparticles (NPs) or E171 triggers tissue damage, and some studies have
Carmen Ximena Martínez‐Escutia, Estefany I. Medina‐Reyes, Eduardo Delgado‐Armenta, Yolanda I. Chirino   +3 more
wiley   +1 more source

Safety and efficacy of colistin versus meropenem in the empirical treatment of ventilator-associated pneumonia as part of a macro-project funded by the Seventh Framework Program of the European Commission studying off-patent antibiotics. study protocol for a randomized controlled trial [PDF]

, 2015
Background: Ventilator-associated pneumonia (VAP) is one of the most common and severe hospital-adquired infections, and multidrugresistant gram-negative bacilli (MDR-GNB) constitute the main etiology in many countries.
Clara Rosso, Fernández, DE BLASI, Roberto Alberto, George, Dimopoulos, José Garnacho, Montero, José Miguel, Cisneros, Massimo, Antonelli, The MagicBullet study, Group   +6 more
core   +1 more source

A preventive strategy for the control of aphids in sweet pepper using lacewings and micrococcinelid beetles

Insect Science, EarlyView.
Aphids pose a serious risk to horticultural crops. Current biocontrol strategies often fail due to the poor establishment of natural enemies when aphids are scarce. We evaluated the potential of two aphidophagous predators, Micromus variegatus and Scymnus interruptus, to be used as preventive biocontrol agents, released before aphid infestation.
Jesica Pérez‐Rodríguez, Reinier T. Valstar, Ada Leman, Gerben J. Messelink   +3 more
wiley   +1 more source

Centro de Investigación en Biotecnología: 30 Aniversario

Tecnología en Marcha
El Centro de Investigación en Biotecnología (CIB) de la Escuela de Biología del Instituto Tecnológico de Costa Rica (TEC) cuenta con 14 laboratorios especializados en los cuales se desarrollan más de 40 proyectos de investigación multidisciplinarios en
Laura A Calvo-Castro, Carlos Alvarado-Ulloa   +1 more
doaj   +1 more source