Results 91 to 100 of about 475,736 (375)

A direct-sequence spread-spectrum communication system for integrated sensor microsystems [PDF]

, 2005
Some of the most important challenges in health-care technologies have been identified to be development of noninvasive systems and miniaturization.
Arslan, T., Aydin, N., Cumming, D.R.S.
core   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Transformer models in biomedicine

BMC Medical Informatics and Decision Making
Deep neural networks (DNN) have fundamentally revolutionized the artificial intelligence (AI) field. The transformer model is a type of DNN that was originally used for the natural language processing tasks and has since gained more and more attention ...
S. Madan, Manuel Lentzen, Johannes Brandt, Daniel Rueckert, M. Hofmann-Apitius, Holger Fröhlich   +5 more
semanticscholar   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

RCSB Protein Data Bank: biological macromolecular structures enabling research and education in fundamental biology, biomedicine, biotechnology and energy

Nucleic Acids Res., 2018
The Research Collaboratory for Structural Bioinformatics Protein Data Bank (RCSB PDB, rcsb.org), the US data center for the global PDB archive, serves thousands of Data Depositors in the Americas and Oceania and makes 3D macromolecular structure data ...
S. Burley, H. Berman, Charmi Bhikadiya, Chunxiao Bi, Li Chen, L. Costanzo, Cole H. Christie, K. Dalenberg, Jose M. Duarte, Shuchismita Dutta, Zukang Feng, Sutapa Ghosh, D. Goodsell, Rachel Kramer Green, Vladimir Guranovic, D. Guzenko, B. Hudson, Tara Kalro, Yuhe Liang, Robert Lowe, Harry Namkoong, E. Peisach, Irina Periskova, A. Prlić, Chris Randle, Alexander S. Rose, P. W. Rose, Raul Sala, Monica R Sekharan, C. Shao, Lihua Tan, Yi-Ping Tao, Yana Valasatava, Maria Voigt, J. Westbrook, Jesse Woo, Huanwang Yang, Jasmine Y. Young, M. Zhuravleva, C. Zardecki   +39 more
semanticscholar   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Sex and gender differences and biases in artificial intelligence for biomedicine and healthcare

npj Digital Medicine, 2020
Precision Medicine implies a deep understanding of inter-individual differences in health and disease that are due to genetic and environmental factors.
D. Cirillo, Silvina Catuara-Solarz, Czuee Morey, E. Guney, L. Subirats, Simona Mellino, A. Gigante, A. Valencia, M. Rementeria, A. S. Chadha, N. Mavridis   +10 more
semanticscholar   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Is China Systematically Buying Up Key Technologies? Chinese M & A transactions in Germany in the context of “Made in China 2025”. Bertelsmann Stiftung GED Study 2018 [PDF]

, 2018
“Made in China 2025” (MIC 2025) is the Chinese central government’s main industrial policy strategy aimed at turning China into the global leader of the fourth industrial revolution.
Jungbluth, Cora
core  

Metal-Organic Framework Derived Nanozymes in Biomedicine.

Accounts of Chemical Research, 2020
ConspectusNanozymes, which integrate the advantages of both nanomaterials and natural enzymes, have accumulated enormous research interest over the past decades because of the opportunity they provide to appreciate and further cultivate artificial ...
Dongdong Wang, Deblin Jana, Yanli Zhao
semanticscholar   +1 more source