Results 181 to 190 of about 116,047 (273)

Multivalency Controls the Growth and Dynamics of a Biomolecular Condensate. [PDF]

J Am Chem Soc
von Hofe J, Abacousnac J, Chen M, Sasazawa M, Javér Kristiansen I, Westrey S, Grier DG, Saurabh S.   +7 more
europepmc   +1 more source

Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. [PDF]

Cell Chem Biol, 2022
Ciancone AM, Hosseinibarkooie S, Bai DL, Borne AL, Ferris HA, Hsu KL.   +5 more
europepmc   +1 more source

Optical Control of Therapeutic Synthetic Cells: Controlling Biomolecule Synthesis, Activation, and Communication

Small Methods, EarlyView.
Combining synthetic cells engineering, cell‐free expression, and optical regulation may enable a new generation of programmable synthetic cell platforms. By providing spatiotemporal control over biomolecule synthesis, activation, transport, release, and communication, light offers a versatile strategy for coordinating proteins, RNAs, peptides, and ...
Gia Bao Leon Hoang, Taniya Chakraborty
wiley   +1 more source

Competitive Mg²⁺ Regulation of Biomolecular Condensate Microenvironments Enables Diverse Macrophage Response. [PDF]

JACS Au
Yu X, Yin C, Liu X, Liu J, Zhu Y, Li D, Zhang D, Lee HJ, Ji B, Tian L.   +9 more
europepmc   +1 more source

ALS-linked mutations impair UBQLN2 stress-induced biomolecular condensate assembly in cells. [PDF]

J Neurochem, 2021
Riley JF, Fioramonti PJ, Rusnock AK, Hehnly H, Castañeda CA.   +4 more
europepmc   +1 more source

Spatial Gene Expression in Fungi: mRNA Localization, Condensates, and Beyond

Yeast, EarlyView.
ABSTRACT Polarized growth and cellular asymmetry are broadly conserved properties of fungal life, from transient bud‐site selection in unicellular yeasts to sustained hyphal extension in filamentous and coenocytic species. While vesicle trafficking, cytoskeletal organization, and cell‐wall remodeling are well‐established contributors to these processes,
Sander van Otterdijk, Zixu Wang, Roan Arends, Evelina Tutucci   +3 more
wiley   +1 more source

Shining light on drug discovery: optogenetic screening for TopBP1 biomolecular condensate inhibitors. [PDF]

NAR Cancer
Morano L, Vie N, Aissanou A, Hodroj D, Garambois V, Fauvre A, Promonet A, Egger T, Bordignon B, Hassen-Khodja C, Fiachetti S, Basbous J, Gongora C, Constantinou A.   +13 more
europepmc   +1 more source

Sperm Selection Using Micro Swim‐Up: Improvement of Chromatin Integrity Compared to Density Gradient Centrifugation

Andrology, EarlyView.
ABSTRACT Background Selecting high‐quality spermatozoa with optimal nuclear integrity is a crucial step in assisted reproductive technologies (ART). While density gradient centrifugation (DGC) is widely used, the associated centrifugation steps may induce cell stress, potentially damaging sperm DNA.
Simone Palini, Serena Benedetti, Silvia De Stefani, Luca Galluzzi, Mariangela Primiterra, Sara Rita D'Errico, Michele Tanturli, Monica Muratori   +7 more
wiley   +1 more source

Compartmentalisation in cAMP signalling: A phase separation perspective

British Journal of Pharmacology, EarlyView.
Cells rely on precise spatiotemporal control of signalling pathways to ensure functional specificity. The compartmentalisation of cyclic AMP (cAMP) and protein kinase A (PKA) signalling enables distinct cellular responses within a crowded cytoplasmic space.
Milda Folkmanaite, Manuela Zaccolo
wiley   +1 more source

The rDNA is biomolecular condensate formed by polymer-polymer phase separation and is sequestered in the nucleolus by transcription and R-loops. [PDF]

Nucleic Acids Res, 2021
Lawrimore J, Kolbin D, Stanton J, Khan M, de Larminat SC, Lawrimore C, Yeh E, Bloom K.   +7 more
europepmc   +1 more source